node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCA91133.1 | SCA91135.1 | LP2241_10271 | LP2241_10273 | Conserved membrane hypothetical protein; Homologs of previously reported genes of unknown function. | Short-chain dehydrogenase; Function of strongly homologous gene; enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.463 |
SCA91133.1 | recG | LP2241_10271 | LP2241_10272 | Conserved membrane hypothetical protein; Homologs of previously reported genes of unknown function. | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. | 0.463 |
SCA91135.1 | SCA91133.1 | LP2241_10273 | LP2241_10271 | Short-chain dehydrogenase; Function of strongly homologous gene; enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Conserved membrane hypothetical protein; Homologs of previously reported genes of unknown function. | 0.463 |
SCA91135.1 | polA | LP2241_10273 | LP2241_10321 | Short-chain dehydrogenase; Function of strongly homologous gene; enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.518 |
SCA91135.1 | recG | LP2241_10273 | LP2241_10272 | Short-chain dehydrogenase; Function of strongly homologous gene; enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. | 0.782 |
SCA91135.1 | recQ | LP2241_10273 | LP2241_30457 | Short-chain dehydrogenase; Function of strongly homologous gene; enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | ATP-dependent DNA helicase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.410 |
SCA91654.1 | recG | LP2241_20425 | LP2241_10272 | Putative Late competence protein ComEC/Rec2, DNA transport (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. | 0.481 |
SCA91654.1 | recJ | LP2241_20425 | LP2241_50144 | Putative Late competence protein ComEC/Rec2, DNA transport (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. | Single-stranded-DNA-specific exonuclease RecJ; Function of strongly homologous gene; enzyme. | 0.604 |
SCA91654.1 | recQ | LP2241_20425 | LP2241_30457 | Putative Late competence protein ComEC/Rec2, DNA transport (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. | ATP-dependent DNA helicase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.457 |
dnaG | dnaN | LP2241_50003 | LP2241_10023 | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.551 |
dnaG | miaA | LP2241_50003 | LP2241_50150 | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | tRNA isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.556 |
dnaG | polA | LP2241_50003 | LP2241_10321 | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.797 |
dnaG | recG | LP2241_50003 | LP2241_10272 | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. | 0.593 |
dnaG | recJ | LP2241_50003 | LP2241_50144 | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | Single-stranded-DNA-specific exonuclease RecJ; Function of strongly homologous gene; enzyme. | 0.716 |
dnaG | topA | LP2241_50003 | LP2241_30337 | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.595 |
dnaN | dnaG | LP2241_10023 | LP2241_50003 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 0.551 |
dnaN | polA | LP2241_10023 | LP2241_10321 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.999 |
dnaN | recG | LP2241_10023 | LP2241_10272 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. | 0.605 |
dnaN | recJ | LP2241_10023 | LP2241_50144 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Single-stranded-DNA-specific exonuclease RecJ; Function of strongly homologous gene; enzyme. | 0.579 |
dnaN | recQ | LP2241_10023 | LP2241_30457 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | ATP-dependent DNA helicase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.726 |