node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCA91909.1 | cysK | LP2241_30098 | LP2241_20121 | Putative methyl-tetrahydrofolate methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Cysteine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.832 |
SCA91909.1 | hom | LP2241_30098 | LP2241_30260 | Putative methyl-tetrahydrofolate methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Homoserine dehydrogenase; Function experimentally demonstrated in the studied genus; enzyme. | 0.858 |
SCA91909.1 | ilvA | LP2241_30098 | LP2241_10260 | Putative methyl-tetrahydrofolate methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | L-threonine dehydratase biosynthetic IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.830 |
SCA91909.1 | luxS | LP2241_30098 | LP2241_10132 | Putative methyl-tetrahydrofolate methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | S-ribosylhomocysteine lyase / Autoinducer-2 production protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.948 |
SCA91909.1 | metA | LP2241_30098 | LP2241_30031 | Putative methyl-tetrahydrofolate methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.469 |
SCA91909.1 | metB | LP2241_30098 | LP2241_20227 | Putative methyl-tetrahydrofolate methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Cystathionine gamma-synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.957 |
SCA91909.1 | metE | LP2241_30098 | LP2241_30079 | Putative methyl-tetrahydrofolate methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.935 |
SCA91909.1 | patB | LP2241_30098 | LP2241_20228 | Putative methyl-tetrahydrofolate methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.902 |
cysK | SCA91909.1 | LP2241_20121 | LP2241_30098 | Cysteine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Putative methyl-tetrahydrofolate methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.832 |
cysK | luxS | LP2241_20121 | LP2241_10132 | Cysteine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the cysteine synthase/cystathionine beta- synthase family. | S-ribosylhomocysteine lyase / Autoinducer-2 production protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.873 |
cysK | metB | LP2241_20121 | LP2241_20227 | Cysteine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Cystathionine gamma-synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.987 |
cysK | metE | LP2241_20121 | LP2241_30079 | Cysteine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.836 |
cysK | patB | LP2241_20121 | LP2241_20228 | Cysteine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Putative aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.926 |
hom | SCA91909.1 | LP2241_30260 | LP2241_30098 | Homoserine dehydrogenase; Function experimentally demonstrated in the studied genus; enzyme. | Putative methyl-tetrahydrofolate methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.858 |
hom | ilvA | LP2241_30260 | LP2241_10260 | Homoserine dehydrogenase; Function experimentally demonstrated in the studied genus; enzyme. | L-threonine dehydratase biosynthetic IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.492 |
hom | ilvE | LP2241_30260 | LP2241_30199 | Homoserine dehydrogenase; Function experimentally demonstrated in the studied genus; enzyme. | Branched-chain-amino-acid aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.878 |
hom | luxS | LP2241_30260 | LP2241_10132 | Homoserine dehydrogenase; Function experimentally demonstrated in the studied genus; enzyme. | S-ribosylhomocysteine lyase / Autoinducer-2 production protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.815 |
hom | metA | LP2241_30260 | LP2241_30031 | Homoserine dehydrogenase; Function experimentally demonstrated in the studied genus; enzyme. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.943 |
hom | metB | LP2241_30260 | LP2241_20227 | Homoserine dehydrogenase; Function experimentally demonstrated in the studied genus; enzyme. | Cystathionine gamma-synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.894 |
hom | metE | LP2241_30260 | LP2241_30079 | Homoserine dehydrogenase; Function experimentally demonstrated in the studied genus; enzyme. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.858 |