STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pdhDDihydrolipoyl dehydrogenase; Function of strongly homologous gene; enzyme. (470 aa)    
Predicted Functional Partners:
pdhB
Pyruvate dehydrogenase (E1 beta subunit); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 0.998
pdhC
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 0.997
pdhA
Pyruvate dehydrogenase E1 component subunit alpha; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 
 0.983
nifJ
Pyruvate-flavodoxin oxidoreductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
 0.966
acoB
Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit beta; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 0.954
lplJ
Lipoate-protein ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 
 0.949
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.924
gltB-2
Glutamate synthase, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
    
 0.915
pfl
Formate C-acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
     
 0.909
gdhA
Glutamate dehydrogenase, NADP-specific; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.875
Your Current Organism:
Lactococcus piscium
NCBI taxonomy Id: 1364
Other names: ATCC 700018, CCUG 32207, CCUG 32732, CIP 104371, DSM 6634, JCM 11055, L. piscium, NCFB 2778, NCIMB 13196, strain HRIA 68
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