STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
gpsBCell cycle protein GpsB; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. (139 aa)    
Predicted Functional Partners:
SCA91082.1
Penicillin-binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
   
 
 0.803
ponA
Penicillin-binding protein 1A; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
   
 
 0.677
SCA92907.1
Penicillin-binding protein 1B; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
   
 
 0.623
ezrA
Septation ring formation regulator EzrA; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family.
  
 
 0.610
ybiC
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
  
    0.571
ylmE
Conserved hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
  
  
 0.562
SCA92585.1
Putative Cell division initiation protein DivIVA; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor.
  
  
 0.560
mreC
Putative Cell shape-determining protein MreC; Involved in formation and maintenance of cell shape.
  
 
 0.519
sepF
Cell division protein SepF; Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
  
  
 0.510
pyrK
Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
       0.465
Your Current Organism:
Lactococcus piscium
NCBI taxonomy Id: 1364
Other names: ATCC 700018, CCUG 32207, CCUG 32732, CIP 104371, DSM 6634, JCM 11055, L. piscium, NCFB 2778, NCIMB 13196, strain HRIA 68
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