STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (216 aa)    
Predicted Functional Partners:
exoA
Exodeoxyribonuclease; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 0.988
SCA91847.1
Conserved hypothetical protein, (Chromosome replication initiation protein domain); Homologs of previously reported genes of unknown function.
  
  
 0.907
mutM
Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
   
  
 0.826
trmK
tRNA (adenine(22)-N(1))-methyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
       0.796
ykiD
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
       0.784
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
 
 0.776
SCA91846.1
Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.
       0.528
recJ
Single-stranded-DNA-specific exonuclease RecJ; Function of strongly homologous gene; enzyme.
  
  
 0.516
mutL
DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
   
 
 0.514
SCA91493.1
Putative ATP-dependent helicase DinG/DNA polymerase III, epsilon subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
  
 0.506
Your Current Organism:
Lactococcus piscium
NCBI taxonomy Id: 1364
Other names: ATCC 700018, CCUG 32207, CCUG 32732, CIP 104371, DSM 6634, JCM 11055, L. piscium, NCFB 2778, NCIMB 13196, strain HRIA 68
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