Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| clpE | clpP | LP2241_50001 | LP2241_20132 | ATP-dependent Clp protease ATP-binding subunit ClpE (class III stress gene); Function experimentally demonstrated in the studied genus; factor; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.936 |
| clpE | clpX | LP2241_50001 | LP2241_30262 | ATP-dependent Clp protease ATP-binding subunit ClpE (class III stress gene); Function experimentally demonstrated in the studied genus; factor; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.625 |
| clpE | ctsR | LP2241_50001 | LP2241_50139 | ATP-dependent Clp protease ATP-binding subunit ClpE (class III stress gene); Function experimentally demonstrated in the studied genus; factor; Belongs to the ClpA/ClpB family. | Transcriptional regulator CtsR, (repressor of class III stress genes); Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the CtsR family. | 0.786 |
| clpE | dnaJ | LP2241_50001 | LP2241_10105 | ATP-dependent Clp protease ATP-binding subunit ClpE (class III stress gene); Function experimentally demonstrated in the studied genus; factor; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.759 |
| clpE | dnaK | LP2241_50001 | LP2241_20419 | ATP-dependent Clp protease ATP-binding subunit ClpE (class III stress gene); Function experimentally demonstrated in the studied genus; factor; Belongs to the ClpA/ClpB family. | Chaperone Hsp70, co-chaperone with DnaJ; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.909 |
| clpE | groL | LP2241_50001 | LP2241_50503 | ATP-dependent Clp protease ATP-binding subunit ClpE (class III stress gene); Function experimentally demonstrated in the studied genus; factor; Belongs to the ClpA/ClpB family. | Cpn60 chaperonin GroEL, large subunit of GroESL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.781 |
| clpE | groS | LP2241_50001 | LP2241_50504 | ATP-dependent Clp protease ATP-binding subunit ClpE (class III stress gene); Function experimentally demonstrated in the studied genus; factor; Belongs to the ClpA/ClpB family. | Cpn10 chaperonin GroES, small subunit of GroESL; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.700 |
| clpE | grpE | LP2241_50001 | LP2241_20418 | ATP-dependent Clp protease ATP-binding subunit ClpE (class III stress gene); Function experimentally demonstrated in the studied genus; factor; Belongs to the ClpA/ClpB family. | Protein GrpE (heat shock protein HSP); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several [...] | 0.721 |
| clpE | hrcA | LP2241_50001 | LP2241_20417 | ATP-dependent Clp protease ATP-binding subunit ClpE (class III stress gene); Function experimentally demonstrated in the studied genus; factor; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor HrcA, (HSP operon); Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.634 |
| clpE | mecA | LP2241_50001 | LP2241_20154 | ATP-dependent Clp protease ATP-binding subunit ClpE (class III stress gene); Function experimentally demonstrated in the studied genus; factor; Belongs to the ClpA/ClpB family. | Putative adapter protein(MecA); Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis; Belongs to the MecA family. | 0.627 |
| clpP | clpE | LP2241_20132 | LP2241_50001 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent Clp protease ATP-binding subunit ClpE (class III stress gene); Function experimentally demonstrated in the studied genus; factor; Belongs to the ClpA/ClpB family. | 0.936 |
| clpP | clpX | LP2241_20132 | LP2241_30262 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.994 |
| clpP | ctsR | LP2241_20132 | LP2241_50139 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Transcriptional regulator CtsR, (repressor of class III stress genes); Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the CtsR family. | 0.635 |
| clpP | dnaJ | LP2241_20132 | LP2241_10105 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.623 |
| clpP | dnaK | LP2241_20132 | LP2241_20419 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Chaperone Hsp70, co-chaperone with DnaJ; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.823 |
| clpP | groL | LP2241_20132 | LP2241_50503 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Cpn60 chaperonin GroEL, large subunit of GroESL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.853 |
| clpP | groS | LP2241_20132 | LP2241_50504 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Cpn10 chaperonin GroES, small subunit of GroESL; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.783 |
| clpP | grpE | LP2241_20132 | LP2241_20418 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Protein GrpE (heat shock protein HSP); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several [...] | 0.783 |
| clpP | hrcA | LP2241_20132 | LP2241_20417 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Heat-inducible transcription repressor HrcA, (HSP operon); Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.786 |
| clpX | clpE | LP2241_30262 | LP2241_50001 | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | ATP-dependent Clp protease ATP-binding subunit ClpE (class III stress gene); Function experimentally demonstrated in the studied genus; factor; Belongs to the ClpA/ClpB family. | 0.625 |
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