| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| adk | apt | LP2241_10246 | LP2241_50143 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.917 |
| adk | gmk | LP2241_10246 | LP2241_50171 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.711 |
| adk | guaA | LP2241_10246 | LP2241_30320 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.488 |
| adk | hpt | LP2241_10246 | LP2241_10009 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Hypoxanthine-guanine phosphoribosyltransferase; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.895 |
| adk | purB | LP2241_10246 | LP2241_30514 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Adenylosuccinate lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.933 |
| apt | adk | LP2241_50143 | LP2241_10246 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.917 |
| apt | gmk | LP2241_50143 | LP2241_50171 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.948 |
| apt | guaA | LP2241_50143 | LP2241_30320 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.981 |
| apt | guaC | LP2241_50143 | LP2241_30051 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.926 |
| apt | hpt | LP2241_50143 | LP2241_10009 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine-guanine phosphoribosyltransferase; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.924 |
| apt | pupG | LP2241_50143 | LP2241_30438 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Purine nucleoside phosphorylase 1; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.926 |
| apt | purB | LP2241_50143 | LP2241_30514 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.953 |
| apt | purH | LP2241_50143 | LP2241_30281 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.945 |
| apt | recJ | LP2241_50143 | LP2241_50144 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Single-stranded-DNA-specific exonuclease RecJ; Function of strongly homologous gene; enzyme. | 0.845 |
| apt | xpt | LP2241_50143 | LP2241_50065 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase (modular protein); Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.917 |
| gmk | adk | LP2241_50171 | LP2241_10246 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.711 |
| gmk | apt | LP2241_50171 | LP2241_50143 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.948 |
| gmk | guaA | LP2241_50171 | LP2241_30320 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.975 |
| gmk | guaC | LP2241_50171 | LP2241_30051 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.916 |
| gmk | hpt | LP2241_50171 | LP2241_10009 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Hypoxanthine-guanine phosphoribosyltransferase; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.917 |