| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SCA91217.1 | SCA91909.1 | LP2241_10355 | LP2241_30098 | GAF domain protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative methyl-tetrahydrofolate methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.900 |
| SCA91217.1 | metE | LP2241_10355 | LP2241_30079 | GAF domain protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.900 |
| SCA91217.1 | metK | LP2241_10355 | LP2241_50173 | GAF domain protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.900 |
| SCA91909.1 | SCA91217.1 | LP2241_30098 | LP2241_10355 | Putative methyl-tetrahydrofolate methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | GAF domain protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.900 |
| SCA91909.1 | metE | LP2241_30098 | LP2241_30079 | Putative methyl-tetrahydrofolate methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.935 |
| SCA91909.1 | metF | LP2241_30098 | LP2241_20332 | Putative methyl-tetrahydrofolate methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Methylenetetrahydrofolate reductase; Function of strongly homologous gene; enzyme; Belongs to the methylenetetrahydrofolate reductase family. | 0.710 |
| SCA91909.1 | metK | LP2241_30098 | LP2241_50173 | Putative methyl-tetrahydrofolate methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.961 |
| SCA92980.1 | metK | LP2241_50560 | LP2241_50173 | NAD dependent epimerase/dehydratase family protein; Function of strongly homologous gene; enzyme. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.973 |
| gmk | guaA | LP2241_50171 | LP2241_30320 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.975 |
| gmk | metK | LP2241_50171 | LP2241_50173 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.700 |
| guaA | gmk | LP2241_30320 | LP2241_50171 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.975 |
| guaA | metK | LP2241_30320 | LP2241_50173 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.731 |
| guaA | mtnN | LP2241_30320 | LP2241_50414 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | 0.502 |
| guaA | purF | LP2241_30320 | LP2241_30551 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.792 |
| metE | SCA91217.1 | LP2241_30079 | LP2241_10355 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | GAF domain protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.900 |
| metE | SCA91909.1 | LP2241_30079 | LP2241_30098 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Putative methyl-tetrahydrofolate methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.935 |
| metE | metF | LP2241_30079 | LP2241_20332 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Methylenetetrahydrofolate reductase; Function of strongly homologous gene; enzyme; Belongs to the methylenetetrahydrofolate reductase family. | 0.833 |
| metE | metK | LP2241_30079 | LP2241_50173 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.962 |
| metE | mtnN | LP2241_30079 | LP2241_50414 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | 0.424 |
| metF | SCA91909.1 | LP2241_20332 | LP2241_30098 | Methylenetetrahydrofolate reductase; Function of strongly homologous gene; enzyme; Belongs to the methylenetetrahydrofolate reductase family. | Putative methyl-tetrahydrofolate methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.710 |