AYL99_11931 protein (Fonsecaea erecta) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

AYL99_11931

RING-type domain-containing protein. (228 aa)

Predicted Functional Partners:

AYL99_06853

0.630

AYL99_11308

0.626

AYL99_03733

0.626

AYL99_02996

0.626

AYL99_12028

0.620

AYL99_05600

0.620

AYL99_01398

0.620

AYL99_11389

0.604

AYL99_10140

0.561

AYL99_08444

0.518

Your Current Organism:

Fonsecaea erecta

NCBI taxonomy Id: 1367422
Other names: F. erecta, Fonsecaea erecta V. A. Vicente, Najafzadeh, Sun & de Hoog 2013, Fonsecaea sp. RG-2013a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AYL99_01398	AYL99_02996	A0A179A1K2	A0A178ZVH7	Ubiquitin-40S ribosomal protein S27a.	Polyubiquitin.	0.964
AYL99_01398	AYL99_03733	A0A179A1K2	A0A178ZNZ6	Ubiquitin-40S ribosomal protein S27a.	Uncharacterized protein.	0.865
AYL99_01398	AYL99_06853	A0A179A1K2	A0A178ZKK4	Ubiquitin-40S ribosomal protein S27a.	Phosphodiesterase.	0.424
AYL99_01398	AYL99_08444	A0A179A1K2	A0A178ZE13	Ubiquitin-40S ribosomal protein S27a.	Fanconi anemia group M protein.	0.802
AYL99_01398	AYL99_10140	A0A179A1K2	A0A178Z880	Ubiquitin-40S ribosomal protein S27a.	Uncharacterized protein.	0.998
AYL99_01398	AYL99_11308	A0A179A1K2	A0A178Z518	Ubiquitin-40S ribosomal protein S27a.	Uncharacterized protein.	0.865
AYL99_01398	AYL99_11389	A0A179A1K2	A0A178Z3D3	Ubiquitin-40S ribosomal protein S27a.	SUMO-conjugating enzyme ubc9; Belongs to the ubiquitin-conjugating enzyme family.	0.777
AYL99_01398	AYL99_11931	A0A179A1K2	A0A178Z289	Ubiquitin-40S ribosomal protein S27a.	RING-type domain-containing protein.	0.620
AYL99_02996	AYL99_01398	A0A178ZVH7	A0A179A1K2	Polyubiquitin.	Ubiquitin-40S ribosomal protein S27a.	0.964
AYL99_02996	AYL99_05600	A0A178ZVH7	A0A178ZLB9	Polyubiquitin.	BZIP domain-containing protein.	0.950
AYL99_02996	AYL99_08444	A0A178ZVH7	A0A178ZE13	Polyubiquitin.	Fanconi anemia group M protein.	0.799
AYL99_02996	AYL99_10140	A0A178ZVH7	A0A178Z880	Polyubiquitin.	Uncharacterized protein.	0.999
AYL99_02996	AYL99_11389	A0A178ZVH7	A0A178Z3D3	Polyubiquitin.	SUMO-conjugating enzyme ubc9; Belongs to the ubiquitin-conjugating enzyme family.	0.835
AYL99_02996	AYL99_11931	A0A178ZVH7	A0A178Z289	Polyubiquitin.	RING-type domain-containing protein.	0.626
AYL99_02996	AYL99_12028	A0A178ZVH7	A0A178Z1U9	Polyubiquitin.	BZIP domain-containing protein.	0.950
AYL99_03733	AYL99_01398	A0A178ZNZ6	A0A179A1K2	Uncharacterized protein.	Ubiquitin-40S ribosomal protein S27a.	0.865
AYL99_03733	AYL99_05600	A0A178ZNZ6	A0A178ZLB9	Uncharacterized protein.	BZIP domain-containing protein.	0.865
AYL99_03733	AYL99_08444	A0A178ZNZ6	A0A178ZE13	Uncharacterized protein.	Fanconi anemia group M protein.	0.799
AYL99_03733	AYL99_10140	A0A178ZNZ6	A0A178Z880	Uncharacterized protein.	Uncharacterized protein.	0.966
AYL99_03733	AYL99_11389	A0A178ZNZ6	A0A178Z3D3	Uncharacterized protein.	SUMO-conjugating enzyme ubc9; Belongs to the ubiquitin-conjugating enzyme family.	0.824

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Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.782

expected number of edges:

22

PPI enrichment p-value:

0.778

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018106

Peptidyl-histidine phosphorylation

6 of 58

1.72

2.5

5.81e-07

GO:0000160

Phosphorelay signal transduction system

6 of 94

1.51

1.98

3.00e-06

GO:0016310

Phosphorylation

7 of 189

1.27

1.56

3.64e-06

GO:0050896

Response to stimulus

10 of 452

1.05

1.26

2.06e-07

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004673

Protein histidine kinase activity

7 of 62

1.76

3.08

8.78e-09

GO:0000155

Phosphorelay sensor kinase activity

3 of 35

1.64

1.09

0.0050

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3899

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and Signal transduction response regulator, receiver domain

7 of 19

2.27

5.41

2.04e-12

CL:3897

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily, and OmpR/PhoB-type DNA-binding domain

8 of 30

2.13

5.31

4.33e-13

CL:3901

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and PAS fold-3

4 of 11

2.27

2.91

1.75e-06

CL:3903

PAS fold, and PAS fold-4

3 of 5

2.48

2.32

4.49e-05

CL:3923

Mixed, incl. Peptidyl-aspartic acid modification, and Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

3 of 7

2.34

2.14

8.64e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lagg02020

Two-component system

6 of 141

1.33

1.55

1.50e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

8 of 72

1.75

3.6

4.49e-11

KW-0418

Kinase

5 of 115

1.34

1.33

0.00020

KW-0808

Transferase

6 of 620

0.69

0.4

0.0413

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

7 of 34

2.02

4.19

1.48e-10

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

7 of 36

1.99

4.13

1.48e-10

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

7 of 38

1.97

4.07

1.58e-10

IPR005467

Histidine kinase domain

7 of 39

1.96

4.04

1.58e-10

IPR003594

Histidine kinase/HSP90-like ATPase

7 of 42

1.93

3.93

2.13e-10

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

7 of 39

1.96

4.23

3.66e-11

SM00387

Histidine kinase-like ATPases

7 of 44

1.91

4.05

5.27e-11

SM00448

cheY-homologous receiver domain

8 of 67

1.78

3.8

1.64e-11

SM00091

PAS domain

4 of 33

1.79

2.11

1.86e-05

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

2 of 23

1.64

0.77

0.0295

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