AYL99_10814 protein (Fonsecaea erecta) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

AYL99_10814

Aryl-alcohol dehydrogenase. (377 aa)

Predicted Functional Partners:

AYL99_03027

0.914

AYL99_04274

0.868

AYL99_01769

0.841

AYL99_11412

0.686

AYL99_10643

0.686

AYL99_08698

0.686

AYL99_05094

0.686

AYL99_05691

0.686

AYL99_03818

0.686

AYL99_07718

0.635

Your Current Organism:

Fonsecaea erecta

NCBI taxonomy Id: 1367422
Other names: F. erecta, Fonsecaea erecta V. A. Vicente, Najafzadeh, Sun & de Hoog 2013, Fonsecaea sp. RG-2013a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AYL99_01769	AYL99_03818	A0A178ZS90	A0A178ZRJ1	ADH_zinc_N domain-containing protein.	Fe-ADH domain-containing protein.	0.612
AYL99_01769	AYL99_04274	A0A178ZS90	A0A178ZRI5	ADH_zinc_N domain-containing protein.	Fe-ADH domain-containing protein.	0.960
AYL99_01769	AYL99_05094	A0A178ZS90	A0A178ZK97	ADH_zinc_N domain-containing protein.	Uncharacterized protein.	0.612
AYL99_01769	AYL99_05691	A0A178ZS90	A0A178ZLK8	ADH_zinc_N domain-containing protein.	Alcohol dehydrogenase 4.	0.612
AYL99_01769	AYL99_07718	A0A178ZS90	A0A178ZFT6	ADH_zinc_N domain-containing protein.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.772
AYL99_01769	AYL99_08698	A0A178ZS90	A0A178ZAU4	ADH_zinc_N domain-containing protein.	Fe-ADH domain-containing protein.	0.612
AYL99_01769	AYL99_10643	A0A178ZS90	A0A178Z6Y1	ADH_zinc_N domain-containing protein.	Fe-ADH domain-containing protein.	0.612
AYL99_01769	AYL99_10814	A0A178ZS90	A0A178Z5R8	ADH_zinc_N domain-containing protein.	Aryl-alcohol dehydrogenase.	0.841
AYL99_01769	AYL99_11412	A0A178ZS90	A0A178Z441	ADH_zinc_N domain-containing protein.	Uncharacterized protein.	0.612
AYL99_03027	AYL99_10814	A0A178ZVI9	A0A178Z5R8	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	Aryl-alcohol dehydrogenase.	0.914
AYL99_03818	AYL99_01769	A0A178ZRJ1	A0A178ZS90	Fe-ADH domain-containing protein.	ADH_zinc_N domain-containing protein.	0.612
AYL99_03818	AYL99_07718	A0A178ZRJ1	A0A178ZFT6	Fe-ADH domain-containing protein.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.604
AYL99_03818	AYL99_10814	A0A178ZRJ1	A0A178Z5R8	Fe-ADH domain-containing protein.	Aryl-alcohol dehydrogenase.	0.686
AYL99_04274	AYL99_01769	A0A178ZRI5	A0A178ZS90	Fe-ADH domain-containing protein.	ADH_zinc_N domain-containing protein.	0.960
AYL99_04274	AYL99_07718	A0A178ZRI5	A0A178ZFT6	Fe-ADH domain-containing protein.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.805
AYL99_04274	AYL99_10814	A0A178ZRI5	A0A178Z5R8	Fe-ADH domain-containing protein.	Aryl-alcohol dehydrogenase.	0.868
AYL99_05094	AYL99_01769	A0A178ZK97	A0A178ZS90	Uncharacterized protein.	ADH_zinc_N domain-containing protein.	0.612
AYL99_05094	AYL99_07718	A0A178ZK97	A0A178ZFT6	Uncharacterized protein.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.604
AYL99_05094	AYL99_10814	A0A178ZK97	A0A178Z5R8	Uncharacterized protein.	Aryl-alcohol dehydrogenase.	0.686
AYL99_05691	AYL99_01769	A0A178ZLK8	A0A178ZS90	Alcohol dehydrogenase 4.	ADH_zinc_N domain-containing protein.	0.612

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Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.927

expected number of edges:

15

PPI enrichment p-value:

7.84e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000398

mRNA splicing, via spliceosome

11 of 275

2.2

8.01

3.58e-21

GO:0022618

Ribonucleoprotein complex assembly

3 of 182

1.81

1.29

0.0024

GO:0000387

Spliceosomal snRNP assembly

2 of 29

2.44

1.26

0.0047

GO:0000245

Spliceosomal complex assembly

2 of 49

2.21

1.03

0.0123

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

7 of 1120

1.39

1.75

4.32e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071013

Catalytic step 2 spliceosome

10 of 161

2.39

8.97

3.29e-21

GO:0005681

Spliceosomal complex

11 of 278

2.19

8.16

8.18e-22

GO:0071007

U2-type catalytic step 2 spliceosome

4 of 30

2.72

4.25

1.00e-08

GO:0000974

Prp19 complex

4 of 30

2.72

4.25

1.00e-08

GO:0005684

U2-type spliceosomal complex

5 of 113

2.24

3.93

7.75e-09

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7916

Mixed, incl. Prp19 complex, and Cwf19-like protein

8 of 14

3.35

11.45

7.10e-22

CL:7918

Mixed, incl. Positive regulation of RNA splicing, and Post-spliceosomal complex

5 of 7

3.45

7.23

7.06e-14

CL:8120

U2 snRNP, and SF3B4, RNA recognition motif 1

3 of 29

2.61

1.40e-05

CL:8121

U2 snRNP, and SF3B4, RNA recognition motif 1

2 of 23

2.54

1.37

0.0030

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

aqu03040

Spliceosome

11 of 109

2.6

12.05

5.44e-27

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72172

mRNA Splicing

11 of 354

2.09

7.25

1.25e-20

MAP-72163

mRNA Splicing - Major Pathway

10 of 328

2.08

6.64

2.55e-18

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

11 of 476

1.96

6.26

1.55e-19

MAP-8953854

Metabolism of RNA

11 of 1040

1.62

3.89

3.89e-16

MAP-6781823

Formation of TC-NER Pre-Incision Complex

4 of 92

2.23

2.93

1.44e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005681

Spliceosomal complex

6 of 148

2.2

4.38

4.56e-10

GOCC:0000974

Prp19 complex

4 of 29

2.74

4.06

2.52e-08

GOCC:1990904

Ribonucleoprotein complex

8 of 488

1.81

3.78

4.87e-11

GOCC:0071013

Catalytic step 2 spliceosome

4 of 42

2.58

3.73

8.04e-08

GOCC:0005634

Nucleus

8 of 2291

1.14

1.36

1.61e-06

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0508

mRNA splicing

2 of 22

2.56

1.3

0.0041

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