AYL99_10046 protein (Fonsecaea erecta) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

AYL99_10046

COesterase domain-containing protein. (583 aa)

Predicted Functional Partners:

AYL99_11708

0.810

AYL99_08056

0.810

AYL99_09823

0.790

AYL99_03644

0.726

AYL99_11205

0.721

AYL99_05826

0.692

AYL99_01487

0.579

AYL99_09576

0.575

AYL99_09774

0.560

AYL99_11300

0.541

Your Current Organism:

Fonsecaea erecta

NCBI taxonomy Id: 1367422
Other names: F. erecta, Fonsecaea erecta V. A. Vicente, Najafzadeh, Sun & de Hoog 2013, Fonsecaea sp. RG-2013a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AYL99_01487	AYL99_03644	A0A179A301	A0A178ZPQ3	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	GP-PDE domain-containing protein.	0.769
AYL99_01487	AYL99_05826	A0A179A301	A0A178ZLZ2	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Uncharacterized protein.	0.692
AYL99_01487	AYL99_08056	A0A179A301	A0A178ZC30	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Uncharacterized protein.	0.810
AYL99_01487	AYL99_09576	A0A179A301	A0A178Z9C9	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.577
AYL99_01487	AYL99_09774	A0A179A301	A0A178Z7E2	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	DRIM domain-containing protein.	0.560
AYL99_01487	AYL99_09823	A0A179A301	A0A178Z852	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	0.790
AYL99_01487	AYL99_10046	A0A179A301	A0A178Z7X3	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	COesterase domain-containing protein.	0.579
AYL99_01487	AYL99_11205	A0A179A301	A0A178Z4T3	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	COesterase domain-containing protein.	0.802
AYL99_01487	AYL99_11300	A0A179A301	A0A178Z556	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	CBF domain-containing protein.	0.541
AYL99_01487	AYL99_11708	A0A179A301	A0A178Z4Q8	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Uncharacterized protein.	0.810
AYL99_03644	AYL99_01487	A0A178ZPQ3	A0A179A301	GP-PDE domain-containing protein.	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.769
AYL99_03644	AYL99_05826	A0A178ZPQ3	A0A178ZLZ2	GP-PDE domain-containing protein.	Uncharacterized protein.	0.811
AYL99_03644	AYL99_08056	A0A178ZPQ3	A0A178ZC30	GP-PDE domain-containing protein.	Uncharacterized protein.	0.827
AYL99_03644	AYL99_09576	A0A178ZPQ3	A0A178Z9C9	GP-PDE domain-containing protein.	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.767
AYL99_03644	AYL99_10046	A0A178ZPQ3	A0A178Z7X3	GP-PDE domain-containing protein.	COesterase domain-containing protein.	0.726
AYL99_03644	AYL99_11205	A0A178ZPQ3	A0A178Z4T3	GP-PDE domain-containing protein.	COesterase domain-containing protein.	0.769
AYL99_03644	AYL99_11708	A0A178ZPQ3	A0A178Z4Q8	GP-PDE domain-containing protein.	Uncharacterized protein.	0.827
AYL99_05826	AYL99_01487	A0A178ZLZ2	A0A179A301	Uncharacterized protein.	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.692
AYL99_05826	AYL99_03644	A0A178ZLZ2	A0A178ZPQ3	Uncharacterized protein.	GP-PDE domain-containing protein.	0.811
AYL99_05826	AYL99_08056	A0A178ZLZ2	A0A178ZC30	Uncharacterized protein.	Uncharacterized protein.	0.942

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Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.834

expected number of edges:

13

PPI enrichment p-value:

0.00204

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006265

DNA topological change

3 of 7

2.29

1.54

0.0013

GO:0006259

DNA metabolic process

5 of 233

0.99

0.54

0.0380

GO:0090304

Nucleic acid metabolic process

6 of 426

0.81

0.45

0.0422

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003918

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

3 of 4

2.54

1.97

0.00022

GO:0140657

ATP-dependent activity

5 of 157

1.16

0.89

0.0034

GO:0003690

Double-stranded DNA binding

2 of 13

1.85

0.89

0.0192

GO:0035639

Purine ribonucleoside triphosphate binding

7 of 580

0.74

0.53

0.0061

GO:0032555

Purine ribonucleotide binding

7 of 588

0.74

0.53

0.0061

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005694

Chromosome

3 of 26

1.72

1.16

0.0041

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0799

Topoisomerase

2 of 3

2.48

1.1

0.0096

KW-0413

Isomerase

3 of 59

1.37

0.76

0.0203

KW-0963

Cytoplasm

5 of 250

0.96

0.63

0.0127

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013760

DNA topoisomerase, type IIA-like domain superfamily

3 of 4

2.54

1.79

0.00049

IPR013759

DNA topoisomerase, type IIA, subunit B, C-terminal

2 of 2

2.66

0.9

0.0238

IPR013506

DNA topoisomerase, type IIA, subunit B, domain 2

2 of 2

2.66

0.9

0.0238

IPR001241

DNA topoisomerase, type IIA

2 of 2

2.66

0.9

0.0238

IPR006171

TOPRIM domain

2 of 5

2.26

0.8

0.0332

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00433

TopoisomeraseII

2 of 2

2.66

1.35

0.0035

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