AYL99_10149 protein (Fonsecaea erecta) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

AYL99_10149

Zn(2)-C6 fungal-type domain-containing protein. (270 aa)

Predicted Functional Partners:

AYL99_06015

0.548

AYL99_09160

0.526

AYL99_05234

0.465

AYL99_08155

0.452

NOP7

0.444

AYL99_07476

0.420

AYL99_09331

0.406

AYL99_05658

0.403

AYL99_03162

0.401

Your Current Organism:

Fonsecaea erecta

NCBI taxonomy Id: 1367422
Other names: F. erecta, Fonsecaea erecta V. A. Vicente, Najafzadeh, Sun & de Hoog 2013, Fonsecaea sp. RG-2013a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AYL99_03162	AYL99_10149	A0A178ZY37	A0A178Z8A5	Uncharacterized protein.	Zn(2)-C6 fungal-type domain-containing protein.	0.401
AYL99_05234	AYL99_07476	A0A178ZKN9	A0A178ZFY6	40S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family.	60S ribosomal protein L30.	0.999
AYL99_05234	AYL99_08155	A0A178ZKN9	A0A178ZCB2	40S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family.	MHYT domain-containing protein.	0.480
AYL99_05234	AYL99_10149	A0A178ZKN9	A0A178Z8A5	40S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family.	Zn(2)-C6 fungal-type domain-containing protein.	0.465
AYL99_05658	AYL99_07476	A0A178ZMQ5	A0A178ZFY6	Uncharacterized protein.	60S ribosomal protein L30.	0.988
AYL99_05658	AYL99_09331	A0A178ZMQ5	A0A178Z906	Uncharacterized protein.	CP-type G domain-containing protein.	0.419
AYL99_05658	AYL99_10149	A0A178ZMQ5	A0A178Z8A5	Uncharacterized protein.	Zn(2)-C6 fungal-type domain-containing protein.	0.403
AYL99_06015	AYL99_07476	A0A178ZNG6	A0A178ZFY6	WD_REPEATS_REGION domain-containing protein.	60S ribosomal protein L30.	0.873
AYL99_06015	AYL99_09160	A0A178ZNG6	A0A178ZB89	WD_REPEATS_REGION domain-containing protein.	Ipi1_N domain-containing protein.	0.999
AYL99_06015	AYL99_09331	A0A178ZNG6	A0A178Z906	WD_REPEATS_REGION domain-containing protein.	CP-type G domain-containing protein.	0.985
AYL99_06015	AYL99_10149	A0A178ZNG6	A0A178Z8A5	WD_REPEATS_REGION domain-containing protein.	Zn(2)-C6 fungal-type domain-containing protein.	0.548
AYL99_06015	NOP7	A0A178ZNG6	A0A178Z6T5	WD_REPEATS_REGION domain-containing protein.	Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.965
AYL99_07476	AYL99_05234	A0A178ZFY6	A0A178ZKN9	60S ribosomal protein L30.	40S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family.	0.999
AYL99_07476	AYL99_05658	A0A178ZFY6	A0A178ZMQ5	60S ribosomal protein L30.	Uncharacterized protein.	0.988
AYL99_07476	AYL99_06015	A0A178ZFY6	A0A178ZNG6	60S ribosomal protein L30.	WD_REPEATS_REGION domain-containing protein.	0.873
AYL99_07476	AYL99_09160	A0A178ZFY6	A0A178ZB89	60S ribosomal protein L30.	Ipi1_N domain-containing protein.	0.873
AYL99_07476	AYL99_09331	A0A178ZFY6	A0A178Z906	60S ribosomal protein L30.	CP-type G domain-containing protein.	0.913
AYL99_07476	AYL99_10149	A0A178ZFY6	A0A178Z8A5	60S ribosomal protein L30.	Zn(2)-C6 fungal-type domain-containing protein.	0.420
AYL99_07476	NOP7	A0A178ZFY6	A0A178Z6T5	60S ribosomal protein L30.	Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.947
AYL99_08155	AYL99_05234	A0A178ZCB2	A0A178ZKN9	MHYT domain-containing protein.	40S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family.	0.480

page 1 of 3

Network Stats

number of nodes:

5

number of edges:

9

average node degree:

3.6

avg. local clustering coefficient:

0.9

expected number of edges:

11

PPI enrichment p-value:

0.465

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2001295

malonyl-CoA biosynthetic process

2 of 3

2.29

1.15

0.0073

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003700

DNA-binding transcription factor activity

7 of 89

1.36

1.73

3.18e-06

GO:0016743

Carboxyl- or carbamoyltransferase activity

2 of 4

2.17

0.79

0.0348

GO:0003989

acetyl-CoA carboxylase activity

2 of 4

2.17

0.79

0.0348

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009317

acetyl-CoA carboxylase complex

2 of 3

2.29

1.3

0.0038

GO:0005737

Cytoplasm

11 of 1119

0.46

0.38

0.00095

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2244

Mixed, incl. The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to PUBMED:12757941. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules., and Peroxiredoxin activity

4 of 6

2.29

2.56

1.08e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01210

2-Oxocarboxylic acid metabolism

4 of 22

1.73

1.76

0.00012

map00300

Lysine biosynthesis

4 of 24

1.69

1.73

0.00012

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009317

acetyl-CoA carboxylase complex

2 of 4

2.17

0.75

0.0419

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0805

Transcription regulation

7 of 113

1.26

1.52

4.72e-06

KW-0238

DNA-binding

7 of 190

1.04

4.98e-05

KW-0275

Fatty acid biosynthesis

2 of 11

1.73

0.71

0.0408

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01039

Carboxyl transferase domain

2 of 2

2.47

0.83

0.0302

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00345

Helix_turn_helix gluconate operon transcriptional repressor

7 of 12

2.23

5.3

2.51e-12

SM00866

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to PUBMED:12757941. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.

4 of 5

2.37

3.23

5.11e-07

SM00895

This entry represents the C-terminal ligand binding domain of many members of the GntR family. This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding ...

2 of 3

2.29

1.29

0.0040

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