AYL99_10486 protein (Fonsecaea erecta) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

AYL99_10486

HET domain-containing protein. (671 aa)

Predicted Functional Partners:

AYL99_04366

0.587

AYL99_11640

0.580

AYL99_09876

0.580

AYL99_09218

0.550

AYL99_04101

0.547

AYL99_03104

0.547

AYL99_05696

0.544

AYL99_06962

0.542

AYL99_07950

0.536

AYL99_07171

0.536

Your Current Organism:

Fonsecaea erecta

NCBI taxonomy Id: 1367422
Other names: F. erecta, Fonsecaea erecta V. A. Vicente, Najafzadeh, Sun & de Hoog 2013, Fonsecaea sp. RG-2013a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AYL99_03104	AYL99_09876	A0A178ZVY5	A0A178Z7G9	Choline-sulfatase.	Uncharacterized protein.	0.639
AYL99_03104	AYL99_10486	A0A178ZVY5	A0A178Z8K4	Choline-sulfatase.	HET domain-containing protein.	0.547
AYL99_03104	AYL99_11640	A0A178ZVY5	A0A178Z4U4	Choline-sulfatase.	Uncharacterized protein.	0.639
AYL99_04101	AYL99_09876	A0A178ZPY9	A0A178Z7G9	Arylsulfatase; Belongs to the sulfatase family.	Uncharacterized protein.	0.639
AYL99_04101	AYL99_10486	A0A178ZPY9	A0A178Z8K4	Arylsulfatase; Belongs to the sulfatase family.	HET domain-containing protein.	0.547
AYL99_04101	AYL99_11640	A0A178ZPY9	A0A178Z4U4	Arylsulfatase; Belongs to the sulfatase family.	Uncharacterized protein.	0.639
AYL99_04366	AYL99_06962	A0A178ZSI5	A0A178ZIQ4	GPI mannosyltransferase 1; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN- acyl-PI during GPI precursor assembly. Required for cell wall integrity.	GPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis.	0.879
AYL99_04366	AYL99_10486	A0A178ZSI5	A0A178Z8K4	GPI mannosyltransferase 1; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN- acyl-PI during GPI precursor assembly. Required for cell wall integrity.	HET domain-containing protein.	0.587
AYL99_05696	AYL99_10486	A0A178ZLL0	A0A178Z8K4	Phenylalanine ammonia-lyase.	HET domain-containing protein.	0.544
AYL99_06962	AYL99_04366	A0A178ZIQ4	A0A178ZSI5	GPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis.	GPI mannosyltransferase 1; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN- acyl-PI during GPI precursor assembly. Required for cell wall integrity.	0.879
AYL99_06962	AYL99_10486	A0A178ZIQ4	A0A178Z8K4	GPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis.	HET domain-containing protein.	0.542
AYL99_07171	AYL99_09876	A0A178ZF08	A0A178Z7G9	Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family.	Uncharacterized protein.	0.696
AYL99_07171	AYL99_10486	A0A178ZF08	A0A178Z8K4	Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family.	HET domain-containing protein.	0.536
AYL99_07171	AYL99_11640	A0A178ZF08	A0A178Z4U4	Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family.	Uncharacterized protein.	0.696
AYL99_07950	AYL99_09876	A0A178ZC20	A0A178Z7G9	Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family.	Uncharacterized protein.	0.696
AYL99_07950	AYL99_10486	A0A178ZC20	A0A178Z8K4	Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family.	HET domain-containing protein.	0.536
AYL99_07950	AYL99_11640	A0A178ZC20	A0A178Z4U4	Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family.	Uncharacterized protein.	0.696
AYL99_09218	AYL99_10486	A0A178ZDF2	A0A178Z8K4	N-acetylmuramic acid 6-phosphate etherase.	HET domain-containing protein.	0.550
AYL99_09876	AYL99_03104	A0A178Z7G9	A0A178ZVY5	Uncharacterized protein.	Choline-sulfatase.	0.639
AYL99_09876	AYL99_04101	A0A178Z7G9	A0A178ZPY9	Uncharacterized protein.	Arylsulfatase; Belongs to the sulfatase family.	0.639

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Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.8

expected number of edges:

15

PPI enrichment p-value:

0.00173

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006418

tRNA aminoacylation for protein translation

6 of 21

1.54

1.84

1.53e-05

GO:0006426

glycyl-tRNA aminoacylation

2 of 2

2.08

0.95

0.0162

GO:0006520

Cellular amino acid metabolic process

7 of 120

0.85

0.66

0.0022

GO:0019752

Carboxylic acid metabolic process

8 of 199

0.68

0.51

0.0037

GO:0019538

Protein metabolic process

7 of 165

0.71

0.5

0.0074

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004812

aminoacyl-tRNA ligase activity

6 of 22

1.52

1.86

9.78e-06

GO:0016874

Ligase activity

8 of 77

1.1

1.21

9.78e-06

GO:0004820

glycine-tRNA ligase activity

2 of 2

2.08

1.08

0.0090

GO:0005524

ATP binding

8 of 156

0.79

0.67

0.00042

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1512

Mixed, incl. glycyl-tRNA aminoacylation, and Maf-like protein

4 of 7

1.84

1.72

0.00025

CL:1456

Mixed, incl. Isoprenoid metabolic process, and Ubiquinone metabolic process

5 of 35

1.23

1.05

0.0012

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00970

Aminoacyl-tRNA biosynthesis

6 of 26

1.44

1.82

5.11e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0030

Aminoacyl-tRNA synthetase

6 of 20

1.56

2.08

2.35e-06

KW-0648

Protein biosynthesis

6 of 37

1.29

1.45

2.30e-05

KW-0436

Ligase

7 of 64

1.12

1.2

2.30e-05

KW-0067

ATP-binding

7 of 134

0.8

0.64

0.0013

KW-0963

Cytoplasm

6 of 174

0.62

0.37

0.0436

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045864

Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)

5 of 12

1.7

1.88

4.90e-05

IPR006195

Aminoacyl-tRNA synthetase, class II

3 of 7

1.71

0.91

0.0152

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