AYL99_10536 protein (Fonsecaea erecta) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

AYL99_10536

Redoxin domain-containing protein. (207 aa)

Predicted Functional Partners:

AYL99_08636

0.858

AYL99_08301

0.823

AYL99_04374

0.752

AYL99_02366

0.748

AYL99_05377

0.729

AYL99_04256

0.721

AYL99_10168

0.590

AYL99_05214

0.590

AYL99_02204

0.590

AYL99_02008

0.590

Your Current Organism:

Fonsecaea erecta

NCBI taxonomy Id: 1367422
Other names: F. erecta, Fonsecaea erecta V. A. Vicente, Najafzadeh, Sun & de Hoog 2013, Fonsecaea sp. RG-2013a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AYL99_02008	AYL99_08301	A0A178ZTL9	A0A178ZEF7	Transketolase.	Tryptophan synthase.	0.556
AYL99_02008	AYL99_08636	A0A178ZTL9	A0A178ZDQ8	Transketolase.	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	0.578
AYL99_02008	AYL99_10536	A0A178ZTL9	A0A178Z8R0	Transketolase.	Redoxin domain-containing protein.	0.590
AYL99_02204	AYL99_08301	A0A178ZT59	A0A178ZEF7	Transketolase.	Tryptophan synthase.	0.556
AYL99_02204	AYL99_08636	A0A178ZT59	A0A178ZDQ8	Transketolase.	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	0.578
AYL99_02204	AYL99_10536	A0A178ZT59	A0A178Z8R0	Transketolase.	Redoxin domain-containing protein.	0.590
AYL99_02366	AYL99_04374	A0A178ZTN7	A0A178ZRU9	Homoserine dehydrogenase.	Uncharacterized protein.	0.814
AYL99_02366	AYL99_05377	A0A178ZTN7	A0A178ZMX4	Homoserine dehydrogenase.	Hcy-binding domain-containing protein.	0.904
AYL99_02366	AYL99_08301	A0A178ZTN7	A0A178ZEF7	Homoserine dehydrogenase.	Tryptophan synthase.	0.940
AYL99_02366	AYL99_08636	A0A178ZTN7	A0A178ZDQ8	Homoserine dehydrogenase.	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	0.880
AYL99_02366	AYL99_10536	A0A178ZTN7	A0A178Z8R0	Homoserine dehydrogenase.	Redoxin domain-containing protein.	0.748
AYL99_04256	AYL99_10536	A0A178ZS93	A0A178Z8R0	S-methyl-5'-thioadenosine phosphorylase.	Redoxin domain-containing protein.	0.721
AYL99_04374	AYL99_02366	A0A178ZRU9	A0A178ZTN7	Uncharacterized protein.	Homoserine dehydrogenase.	0.814
AYL99_04374	AYL99_05377	A0A178ZRU9	A0A178ZMX4	Uncharacterized protein.	Hcy-binding domain-containing protein.	0.832
AYL99_04374	AYL99_08301	A0A178ZRU9	A0A178ZEF7	Uncharacterized protein.	Tryptophan synthase.	0.517
AYL99_04374	AYL99_10536	A0A178ZRU9	A0A178Z8R0	Uncharacterized protein.	Redoxin domain-containing protein.	0.752
AYL99_05214	AYL99_08301	A0A178ZKL9	A0A178ZEF7	Transket_pyr domain-containing protein.	Tryptophan synthase.	0.556
AYL99_05214	AYL99_08636	A0A178ZKL9	A0A178ZDQ8	Transket_pyr domain-containing protein.	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	0.578
AYL99_05214	AYL99_10536	A0A178ZKL9	A0A178Z8R0	Transket_pyr domain-containing protein.	Redoxin domain-containing protein.	0.590
AYL99_05377	AYL99_02366	A0A178ZMX4	A0A178ZTN7	Hcy-binding domain-containing protein.	Homoserine dehydrogenase.	0.904

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Network Stats

number of nodes:

11

number of edges:

37

average node degree:

6.73

avg. local clustering coefficient:

0.849

expected number of edges:

23

PPI enrichment p-value:

0.00531

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042180

Cellular ketone metabolic process

4 of 68

1.94

1.89

0.00013

GO:0006744

Ubiquinone biosynthetic process

3 of 28

2.2

1.69

0.00058

GO:0044283

Small molecule biosynthetic process

6 of 324

1.44

1.52

9.52e-05

GO:0044281

Small molecule metabolic process

7 of 1034

1.0

0.88

0.00058

GO:0006568

Tryptophan metabolic process

2 of 20

2.17

0.88

0.0234

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004395

Hexaprenyldihydroxybenzoate methyltransferase activity

3 of 3

3.17

2.84

7.18e-06

GO:0008689

3-demethylubiquinone-9 3-O-methyltransferase activity

2 of 2

3.17

1.67

0.00098

GO:0008425

2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity

2 of 3

3.0

1.64

0.0011

GO:0003824

Catalytic activity

11 of 4867

0.53

0.43

0.00087

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019898

Extrinsic component of membrane

3 of 83

1.73

0.88

0.0178

GO:0031314

Extrinsic component of mitochondrial inner membrane

2 of 20

2.17

0.77

0.0373

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:16335

Ubiquinone biosynthesis, and Hexaprenyldihydroxybenzoate methyltransferase activity

3 of 11

2.61

2.04

0.00017

CL:16221

Mixed, incl. Alpha/beta hydrolase fold-3, and FAD-binding domain

4 of 77

1.89

1.79

0.00019

CL:16082

Mixed, incl. Nitrate reductase activity, and Positive regulation of exit from mitosis

2 of 6

2.69

1.32

0.0040

CL:15863

Steroid biosynthesis

2 of 23

2.11

0.8

0.0321

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00130

Ubiquinone and other terpenoid-quinone biosynthesis

3 of 50

1.95

1.69

0.00040

map01100

Metabolic pathways

11 of 2829

0.76

0.77

6.50e-07

map01110

Biosynthesis of secondary metabolites

5 of 795

0.97

0.71

0.0051

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2142789

Ubiquinol biosynthesis

3 of 28

2.2

1.73

0.00048

MAP-8978934

Metabolism of cofactors

3 of 41

2.04

1.55

0.00093

MAP-196854

Metabolism of vitamins and cofactors

3 of 124

1.56

0.85

0.0171

MAP-1430728

Metabolism

9 of 1786

0.87

0.81

9.64e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005739

Mitochondrion

6 of 707

1.1

0.87

0.0025

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0663

Pyridoxal phosphate

2 of 24

2.09

0.81

0.0314

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

2 of 20

2.17

0.81

0.0313

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