AYL99_09292 protein (Fonsecaea erecta) - STRING interaction network

Nodes:

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

AYL99_09292

Uncharacterized protein. (226 aa)

Predicted Functional Partners:

AYL99_02773

0.570

AYL99_09823

0.526

AYL99_09800

0.523

AYL99_02818

0.518

AYL99_07331

0.481

AYL99_11333

0.480

AYL99_10299

0.480

AYL99_06377

0.480

AYL99_06436

0.480

AYL99_05881

0.480

Your Current Organism:

Fonsecaea erecta

NCBI taxonomy Id: 1367422
Other names: F. erecta, Fonsecaea erecta V. A. Vicente, Najafzadeh, Sun & de Hoog 2013, Fonsecaea sp. RG-2013a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AYL99_02773	AYL99_09292	A0A178ZVU1	A0A178ZA67	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Uncharacterized protein.	0.570
AYL99_02818	AYL99_05881	A0A178ZVV9	A0A178ZM37	Uncharacterized protein.	Uncharacterized protein.	0.594
AYL99_02818	AYL99_06377	A0A178ZVV9	A0A178ZH02	Uncharacterized protein.	Uncharacterized protein.	0.594
AYL99_02818	AYL99_06436	A0A178ZVV9	A0A178ZH78	Uncharacterized protein.	Uncharacterized protein.	0.594
AYL99_02818	AYL99_09292	A0A178ZVV9	A0A178ZA67	Uncharacterized protein.	Uncharacterized protein.	0.518
AYL99_02818	AYL99_09823	A0A178ZVV9	A0A178Z852	Uncharacterized protein.	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	0.636
AYL99_02818	AYL99_10299	A0A178ZVV9	A0A178Z791	Uncharacterized protein.	Uncharacterized protein.	0.594
AYL99_02818	AYL99_11333	A0A178ZVV9	A0A178Z370	Uncharacterized protein.	Carrier domain-containing protein.	0.594
AYL99_05881	AYL99_02818	A0A178ZM37	A0A178ZVV9	Uncharacterized protein.	Uncharacterized protein.	0.594
AYL99_05881	AYL99_09292	A0A178ZM37	A0A178ZA67	Uncharacterized protein.	Uncharacterized protein.	0.480
AYL99_06377	AYL99_02818	A0A178ZH02	A0A178ZVV9	Uncharacterized protein.	Uncharacterized protein.	0.594
AYL99_06377	AYL99_09292	A0A178ZH02	A0A178ZA67	Uncharacterized protein.	Uncharacterized protein.	0.480
AYL99_06436	AYL99_02818	A0A178ZH78	A0A178ZVV9	Uncharacterized protein.	Uncharacterized protein.	0.594
AYL99_06436	AYL99_09292	A0A178ZH78	A0A178ZA67	Uncharacterized protein.	Uncharacterized protein.	0.480
AYL99_07331	AYL99_09292	A0A178ZFH4	A0A178ZA67	Deoxyribose-phosphate aldolase.	Uncharacterized protein.	0.481
AYL99_09292	AYL99_02773	A0A178ZA67	A0A178ZVU1	Uncharacterized protein.	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	0.570
AYL99_09292	AYL99_02818	A0A178ZA67	A0A178ZVV9	Uncharacterized protein.	Uncharacterized protein.	0.518
AYL99_09292	AYL99_05881	A0A178ZA67	A0A178ZM37	Uncharacterized protein.	Uncharacterized protein.	0.480
AYL99_09292	AYL99_06377	A0A178ZA67	A0A178ZH02	Uncharacterized protein.	Uncharacterized protein.	0.480
AYL99_09292	AYL99_06436	A0A178ZA67	A0A178ZH78	Uncharacterized protein.	Uncharacterized protein.	0.480

page 1 of 2

Network Stats

number of nodes:

7

number of edges:

10

average node degree:

2.86

avg. local clustering coefficient:

0.8

expected number of edges:

6

PPI enrichment p-value:

0.0961

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046033

AMP metabolic process

3 of 7

2.73

2.58

1.72e-05

GO:0006753

Nucleoside phosphate metabolic process

7 of 207

1.63

2.46

2.09e-07

GO:0009123

Nucleoside monophosphate metabolic process

4 of 49

2.01

2.3

1.79e-05

GO:0009152

Purine ribonucleotide biosynthetic process

4 of 60

1.92

2.13

3.31e-05

GO:0009165

Nucleotide biosynthetic process

5 of 114

1.74

2.11

1.33e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004114

3,5-cyclic-nucleotide phosphodiesterase activity

3 of 6

2.8

2.35

4.86e-05

GO:0047555

3,5-cyclic-GMP phosphodiesterase activity

2 of 2

3.1

1.56

0.0015

GO:0004115

3,5-cyclic-AMP phosphodiesterase activity

2 of 5

2.7

1.34

0.0037

GO:0004017

Adenylate kinase activity

2 of 5

2.7

1.34

0.0037

GO:0043167

Ion binding

9 of 2654

0.63

0.47

0.0037

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11564

3,5-cyclic-GMP phosphodiesterase activity, and cGMP-mediated signaling

5 of 5

3.1

5.86

1.60e-11

CL:11385

Mixed, incl. Metabolism of nucleotides, and Purine metabolism

9 of 105

2.03

5.45

1.21e-14

CL:11428

AMP metabolic process, and Adenylate kinase activity

4 of 6

2.92

4.27

1.32e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00230

Purine metabolism

8 of 135

1.87

4.28

2.55e-12

map00730

Thiamine metabolism

2 of 25

2.0

1.05

0.0097

map01100

Metabolic pathways

8 of 2462

0.61

0.44

0.0075

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-15869

Metabolism of nucleotides

4 of 72

1.84

1.71

0.00026

MAP-74217

Purine salvage

2 of 10

2.4

0.95

0.0179

MAP-8956321

Nucleotide salvage

2 of 17

2.17

0.82

0.0308

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036971

35-cyclic nucleotide phosphodiesterase, catalytic domain superfamily

3 of 6

2.8

2.2

9.65e-05

IPR002073

35-cyclic nucleotide phosphodiesterase, catalytic domain

3 of 6

2.8

2.2

9.65e-05

IPR003607

HD/PDEase domain

3 of 10

2.58

2.14

0.00011

IPR023088

35-cyclic nucleotide phosphodiesterase

2 of 5

2.7

1.12

0.0093

IPR000850

Adenylate kinase/UMP-CMP kinase

2 of 7

2.55

1.04

0.0127

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00471

Metal dependent phosphohydrolases with conserved HD motif.

3 of 11

2.53

2.32

4.59e-05

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