AYL99_09076 protein (Fonsecaea erecta) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

AYL99_09076

DAO domain-containing protein. (195 aa)

Predicted Functional Partners:

AYL99_08301

0.738

AYL99_11186

0.626

AYL99_09822

0.626

AYL99_09028

0.626

AYL99_08258

0.626

AYL99_00482

0.626

AYL99_01297

0.626

AYL99_09205

0.606

AYL99_07250

0.606

AYL99_06438

0.606

Your Current Organism:

Fonsecaea erecta

NCBI taxonomy Id: 1367422
Other names: F. erecta, Fonsecaea erecta V. A. Vicente, Najafzadeh, Sun & de Hoog 2013, Fonsecaea sp. RG-2013a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AYL99_00482	AYL99_06438	A0A178ZXF1	A0A178ZH80	Rieske domain-containing protein.	Uncharacterized protein.	0.487
AYL99_00482	AYL99_07250	A0A178ZXF1	A0A178ZEE4	Rieske domain-containing protein.	DAO domain-containing protein.	0.487
AYL99_00482	AYL99_09076	A0A178ZXF1	A0A178ZB02	Rieske domain-containing protein.	DAO domain-containing protein.	0.626
AYL99_00482	AYL99_09205	A0A178ZXF1	A0A178ZBP9	Rieske domain-containing protein.	DAO domain-containing protein.	0.487
AYL99_01297	AYL99_06438	A0A179A2F9	A0A178ZH80	Pyr_redox_2 domain-containing protein.	Uncharacterized protein.	0.487
AYL99_01297	AYL99_07250	A0A179A2F9	A0A178ZEE4	Pyr_redox_2 domain-containing protein.	DAO domain-containing protein.	0.487
AYL99_01297	AYL99_09076	A0A179A2F9	A0A178ZB02	Pyr_redox_2 domain-containing protein.	DAO domain-containing protein.	0.626
AYL99_01297	AYL99_09205	A0A179A2F9	A0A178ZBP9	Pyr_redox_2 domain-containing protein.	DAO domain-containing protein.	0.487
AYL99_06438	AYL99_00482	A0A178ZH80	A0A178ZXF1	Uncharacterized protein.	Rieske domain-containing protein.	0.487
AYL99_06438	AYL99_01297	A0A178ZH80	A0A179A2F9	Uncharacterized protein.	Pyr_redox_2 domain-containing protein.	0.487
AYL99_06438	AYL99_08258	A0A178ZH80	A0A178ZCK0	Uncharacterized protein.	Zn(2)-C6 fungal-type domain-containing protein.	0.487
AYL99_06438	AYL99_08301	A0A178ZH80	A0A178ZEF7	Uncharacterized protein.	Tryptophan synthase.	0.805
AYL99_06438	AYL99_09028	A0A178ZH80	A0A178ZBR9	Uncharacterized protein.	Pyr_redox_2 domain-containing protein.	0.487
AYL99_06438	AYL99_09076	A0A178ZH80	A0A178ZB02	Uncharacterized protein.	DAO domain-containing protein.	0.606
AYL99_06438	AYL99_09822	A0A178ZH80	A0A178Z7B5	Uncharacterized protein.	Nitrite reductase [NAD(P)H], large subunit.	0.487
AYL99_06438	AYL99_11186	A0A178ZH80	A0A178Z4Q4	Uncharacterized protein.	Pyr_redox_2 domain-containing protein.	0.487
AYL99_07250	AYL99_00482	A0A178ZEE4	A0A178ZXF1	DAO domain-containing protein.	Rieske domain-containing protein.	0.487
AYL99_07250	AYL99_01297	A0A178ZEE4	A0A179A2F9	DAO domain-containing protein.	Pyr_redox_2 domain-containing protein.	0.487
AYL99_07250	AYL99_08258	A0A178ZEE4	A0A178ZCK0	DAO domain-containing protein.	Zn(2)-C6 fungal-type domain-containing protein.	0.487
AYL99_07250	AYL99_08301	A0A178ZEE4	A0A178ZEF7	DAO domain-containing protein.	Tryptophan synthase.	0.805

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

31

PPI enrichment p-value:

2.62e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046488

Phosphatidylinositol metabolic process

6 of 56

1.82

2.65

6.04e-07

GO:0046854

Phosphatidylinositol phosphate biosynthetic process

4 of 14

2.25

2.63

6.81e-06

GO:0006661

Phosphatidylinositol biosynthetic process

5 of 43

1.86

2.39

4.84e-06

GO:0036092

phosphatidylinositol-3-phosphate biosynthetic process

2 of 3

2.62

1.27

0.0048

GO:0046856

Phosphatidylinositol dephosphorylation

2 of 11

2.05

0.81

0.0311

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000285

1-phosphatidylinositol-3-phosphate 5-kinase activity

3 of 3

2.79

2.23

8.31e-05

GO:0032266

phosphatidylinositol-3-phosphate binding

3 of 15

2.09

1.53

0.0011

GO:0005543

Phospholipid binding

4 of 69

1.55

1.27

0.0013

GO:0052866

Phosphatidylinositol phosphate phosphatase activity

2 of 13

1.98

0.77

0.0364

GO:0016773

Phosphotransferase activity, alcohol group as acceptor

4 of 181

1.14

0.65

0.0248

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035032

Phosphatidylinositol 3-kinase complex, class III

5 of 7

2.65

4.54

2.24e-09

GO:0070772

PAS complex

4 of 4

2.79

3.93

4.83e-08

GO:0019898

Extrinsic component of membrane

6 of 48

1.89

3.23

2.09e-08

GO:0000329

Fungal-type vacuole membrane

5 of 56

1.74

2.33

2.77e-06

GO:0005773

Vacuole

6 of 124

1.48

1.93

2.77e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9262

PAS complex

5 of 5

2.79

4.89

6.59e-10

CL:9235

PI Metabolism, and Phosphoinositide phospholipase C family

6 of 19

2.29

4.44

6.59e-10

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00562

Inositol phosphate metabolism

7 of 37

2.07

4.66

1.29e-11

map04070

Phosphatidylinositol signaling system

6 of 36

2.01

3.88

1.20e-09

map04145

Phagosome

5 of 52

1.77

2.56

7.14e-07

map04136

Autophagy - other

2 of 21

1.77

0.91

0.0160

map04138

Autophagy - yeast

3 of 78

1.38

0.89

0.0088

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1660517

Synthesis of PIPs at the late endosome membrane

8 of 9

2.74

8.39

3.09e-17

MAP-1660516

Synthesis of PIPs at the early endosome membrane

8 of 12

2.62

7.96

8.01e-17

MAP-1660514

Synthesis of PIPs at the Golgi membrane

7 of 15

2.46

6.34

9.20e-14

MAP-1483255

PI Metabolism

8 of 29

2.23

6.08

1.63e-14

MAP-1483257

Phospholipid metabolism

9 of 85

1.82

4.38

1.17e-13

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0035032

Phosphatidylinositol 3-kinase complex, class III

5 of 10

2.49

4.11

1.01e-08

GOCC:0070772

PAS complex

4 of 6

2.62

3.52

2.29e-07

GOCC:0098796

Membrane protein complex

7 of 262

1.22

1.42

7.12e-06

GOCC:0001405

PAM complex, Tim23 associated import motor

2 of 6

2.31

1.24

0.0049

GOCC:0000329

Fungal-type vacuole membrane

3 of 42

1.65

1.15

0.0038

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01504

Phosphatidylinositol-4-phosphate 5-Kinase

2 of 3

2.62

0.97

0.0171

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR044769

1-phosphatidylinositol-3-phosphate 5-kinase, PIPK catalytic domain

2 of 2

2.79

0.84

0.0307

IPR027484

Phosphatidylinositol-4-phosphate 5-kinase, N-terminal

2 of 3

2.62

0.83

0.0307

IPR002498

Phosphatidylinositol-4-phosphate 5-kinase, core

2 of 3

2.62

0.83

0.0307

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