AYL99_08047 protein (Fonsecaea erecta) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

AYL99_08047

Uncharacterized protein. (727 aa)

Predicted Functional Partners:

AYL99_11104

0.680

AYL99_03074

0.600

MRI1

0.585

AYL99_11156

0.584

AYL99_06798

0.584

AYL99_02818

0.582

AYL99_07342

0.574

AYL99_11369

0.570

AYL99_06848

0.570

AYL99_01088

0.570

Your Current Organism:

Fonsecaea erecta

NCBI taxonomy Id: 1367422
Other names: F. erecta, Fonsecaea erecta V. A. Vicente, Najafzadeh, Sun & de Hoog 2013, Fonsecaea sp. RG-2013a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AYL99_01088	AYL99_02818	A0A179A0I0	A0A178ZVV9	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.799
AYL99_01088	AYL99_03074	A0A179A0I0	A0A178ZVV5	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.789
AYL99_01088	AYL99_06798	A0A179A0I0	A0A178ZI87	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.997
AYL99_01088	AYL99_06848	A0A179A0I0	A0A178ZIE6	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.935
AYL99_01088	AYL99_07342	A0A179A0I0	A0A178ZF40	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.933
AYL99_01088	AYL99_08047	A0A179A0I0	A0A178ZC14	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.570
AYL99_01088	AYL99_11156	A0A179A0I0	A0A178Z4N2	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.997
AYL99_01088	AYL99_11369	A0A179A0I0	A0A178Z3B2	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.935
AYL99_02818	AYL99_01088	A0A178ZVV9	A0A179A0I0	Uncharacterized protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.799
AYL99_02818	AYL99_03074	A0A178ZVV9	A0A178ZVV5	Uncharacterized protein.	Uncharacterized protein.	0.740
AYL99_02818	AYL99_06798	A0A178ZVV9	A0A178ZI87	Uncharacterized protein.	Uncharacterized protein.	0.855
AYL99_02818	AYL99_06848	A0A178ZVV9	A0A178ZIE6	Uncharacterized protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.799
AYL99_02818	AYL99_07342	A0A178ZVV9	A0A178ZF40	Uncharacterized protein.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.897
AYL99_02818	AYL99_08047	A0A178ZVV9	A0A178ZC14	Uncharacterized protein.	Uncharacterized protein.	0.582
AYL99_02818	AYL99_11104	A0A178ZVV9	A0A178Z5B3	Uncharacterized protein.	AlcB domain-containing protein.	0.441
AYL99_02818	AYL99_11156	A0A178ZVV9	A0A178Z4N2	Uncharacterized protein.	Uncharacterized protein.	0.855
AYL99_02818	AYL99_11369	A0A178ZVV9	A0A178Z3B2	Uncharacterized protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.799
AYL99_03074	AYL99_01088	A0A178ZVV5	A0A179A0I0	Uncharacterized protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.789
AYL99_03074	AYL99_02818	A0A178ZVV5	A0A178ZVV9	Uncharacterized protein.	Uncharacterized protein.	0.740
AYL99_03074	AYL99_06798	A0A178ZVV5	A0A178ZI87	Uncharacterized protein.	Uncharacterized protein.	0.905

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.847

expected number of edges:

13

PPI enrichment p-value:

8.04e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043039

tRNA aminoacylation

9 of 42

2.28

6.88

2.46e-16

GO:0006418

tRNA aminoacylation for protein translation

8 of 40

2.25

6.03

3.32e-14

GO:0006422

aspartyl-tRNA aminoacylation

4 of 4

2.95

4.28

1.31e-08

GO:0006412

Translation

10 of 266

1.53

3.05

1.93e-12

GO:0034645

Cellular macromolecule biosynthetic process

11 of 403

1.39

2.59

5.64e-13

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004812

aminoacyl-tRNA ligase activity

8 of 39

2.26

6.05

3.65e-14

GO:0140101

Catalytic activity, acting on a tRNA

9 of 98

1.91

4.87

4.20e-14

GO:0004815

aspartate-tRNA ligase activity

4 of 4

2.95

4.28

1.31e-08

GO:0016874

Ligase activity

9 of 180

1.65

3.44

6.04e-12

GO:0004818

glutamate-tRNA ligase activity

2 of 2

2.95

1.81

0.00053

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017101

aminoacyl-tRNA synthetase multienzyme complex

3 of 5

2.73

2.35

4.79e-05

GO:0005829

Cytosol

6 of 821

0.82

0.45

0.0455

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11690

Mixed, incl. aspartyl-tRNA aminoacylation, and Amidase, conserved site

6 of 15

2.55

5.48

1.63e-11

CL:11683

Mixed, incl. Amidase, and aspartyl-tRNA aminoacylation

7 of 34

2.27

5.2

6.83e-12

CL:11693

Aspartyl/Asparaginyl-tRNA synthetase, class IIb, and glutamyl-tRNA(Gln) amidotransferase complex

5 of 10

2.65

4.86

4.95e-10

CL:11703

aspartyl-tRNA aminoacylation, and Amidase

3 of 5

2.73

2.67

1.20e-05

CL:6137

Selenoamino acid metabolism, and Mitochondrial tRNA aminoacylation

3 of 13

2.31

2.08

0.00011

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00970

Aminoacyl-tRNA biosynthesis

9 of 49

2.22

6.91

3.70e-17

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-379724

tRNA Aminoacylation

8 of 39

2.26

6.13

2.16e-14

MAP-2408522

Selenoamino acid metabolism

5 of 13

2.54

4.53

1.57e-09

MAP-379716

Cytosolic tRNA aminoacylation

5 of 16

2.45

4.34

2.79e-09

MAP-379726

Mitochondrial tRNA aminoacylation

4 of 17

2.32

3.08

9.23e-07

MAP-72766

Translation

9 of 236

1.53

2.86

7.66e-11

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0017101

aminoacyl-tRNA synthetase multienzyme complex

3 of 4

2.83

2.44

3.47e-05

GOCC:0030956

glutamyl-tRNA(Gln) amidotransferase complex

3 of 8

2.53

2.19

8.17e-05

GOCC:0032991

Protein-containing complex

10 of 2178

0.61

0.5

0.00081

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0436

Ligase

7 of 120

1.72

3.07

3.80e-09

KW-0030

Aminoacyl-tRNA synthetase

4 of 19

2.27

3.06

8.84e-07

KW-0648

Protein biosynthesis

4 of 78

1.66

1.72

0.00011

KW-0067

ATP-binding

4 of 329

1.04

0.62

0.0210

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00152

tRNA synthetases class II (D, K and N)

4 of 7

2.71

3.52

2.64e-07

PF00749

tRNA synthetases class I (E and Q), catalytic domain

3 of 3

2.95

2.74

9.89e-06

PF03950

tRNA synthetases class I (E and Q), anti-codon binding domain

2 of 2

2.95

1.47

0.0022

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002312

Aspartyl/Asparaginyl-tRNA synthetase, class IIb

4 of 5

2.85

3.54

2.93e-07

IPR004364

Aminoacyl-tRNA synthetase, class II (D/K/N)

4 of 7

2.71

3.44

3.83e-07

IPR020058

Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain

3 of 3

2.95

2.71

1.15e-05

IPR000924

Glutamyl/glutaminyl-tRNA synthetase

3 of 3

2.95

2.71

1.15e-05

IPR006195

Aminoacyl-tRNA synthetase, class II

4 of 18

2.3

2.7

5.63e-06

(more ...)

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