AYL99_07933 protein (Fonsecaea erecta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

AYL99_07933

Methyltransf_2 domain-containing protein. (469 aa)

Predicted Functional Partners:

AYL99_04850

0.873

AYL99_07718

0.780

AYL99_07858

0.771

AYL99_02458

0.770

AYL99_07400

0.763

AYL99_09153

0.754

AYL99_05524

0.754

AYL99_01445

0.754

AYL99_03055

0.751

AYL99_11553

0.509

Your Current Organism:

Fonsecaea erecta

NCBI taxonomy Id: 1367422
Other names: F. erecta, Fonsecaea erecta V. A. Vicente, Najafzadeh, Sun & de Hoog 2013, Fonsecaea sp. RG-2013a

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AYL99_01445	AYL99_02458	A0A179A251	A0A178ZUU2	N-acetyltransferase domain-containing protein.	Methyltransf_2 domain-containing protein.	0.754
AYL99_01445	AYL99_03055	A0A179A251	A0A178ZVL4	N-acetyltransferase domain-containing protein.	Methyltransf_2 domain-containing protein.	0.754
AYL99_01445	AYL99_07400	A0A179A251	A0A178ZEU2	N-acetyltransferase domain-containing protein.	Methyltransf_2 domain-containing protein.	0.754
AYL99_01445	AYL99_07858	A0A179A251	A0A178ZCB4	N-acetyltransferase domain-containing protein.	Methyltransf_2 domain-containing protein.	0.754
AYL99_01445	AYL99_07933	A0A179A251	A0A178ZDP9	N-acetyltransferase domain-containing protein.	Methyltransf_2 domain-containing protein.	0.754
AYL99_01445	AYL99_11553	A0A179A251	A0A178Z3Y6	N-acetyltransferase domain-containing protein.	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.777
AYL99_02458	AYL99_01445	A0A178ZUU2	A0A179A251	Methyltransf_2 domain-containing protein.	N-acetyltransferase domain-containing protein.	0.754
AYL99_02458	AYL99_03055	A0A178ZUU2	A0A178ZVL4	Methyltransf_2 domain-containing protein.	Methyltransf_2 domain-containing protein.	0.757
AYL99_02458	AYL99_04850	A0A178ZUU2	A0A178ZJ71	Methyltransf_2 domain-containing protein.	N-acetyltransferase domain-containing protein.	0.868
AYL99_02458	AYL99_05524	A0A178ZUU2	A0A178ZLJ8	Methyltransf_2 domain-containing protein.	N-acetyltransferase domain-containing protein.	0.754
AYL99_02458	AYL99_07400	A0A178ZUU2	A0A178ZEU2	Methyltransf_2 domain-containing protein.	Methyltransf_2 domain-containing protein.	0.763
AYL99_02458	AYL99_07718	A0A178ZUU2	A0A178ZFT6	Methyltransf_2 domain-containing protein.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.780
AYL99_02458	AYL99_07858	A0A178ZUU2	A0A178ZCB4	Methyltransf_2 domain-containing protein.	Methyltransf_2 domain-containing protein.	0.759
AYL99_02458	AYL99_07933	A0A178ZUU2	A0A178ZDP9	Methyltransf_2 domain-containing protein.	Methyltransf_2 domain-containing protein.	0.770
AYL99_02458	AYL99_09153	A0A178ZUU2	A0A178ZB85	Methyltransf_2 domain-containing protein.	Glucosamine 6-phosphate N-acetyltransferase; Belongs to the acetyltransferase family. GNA1 subfamily.	0.754
AYL99_02458	AYL99_11553	A0A178ZUU2	A0A178Z3Y6	Methyltransf_2 domain-containing protein.	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.509
AYL99_03055	AYL99_01445	A0A178ZVL4	A0A179A251	Methyltransf_2 domain-containing protein.	N-acetyltransferase domain-containing protein.	0.754
AYL99_03055	AYL99_02458	A0A178ZVL4	A0A178ZUU2	Methyltransf_2 domain-containing protein.	Methyltransf_2 domain-containing protein.	0.757
AYL99_03055	AYL99_04850	A0A178ZVL4	A0A178ZJ71	Methyltransf_2 domain-containing protein.	N-acetyltransferase domain-containing protein.	0.873
AYL99_03055	AYL99_05524	A0A178ZVL4	A0A178ZLJ8	Methyltransf_2 domain-containing protein.	N-acetyltransferase domain-containing protein.	0.754

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.935

expected number of edges:

15

PPI enrichment p-value:

2.42e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030522

Intracellular receptor signaling pathway

7 of 98

2.03

4.08

4.00e-10

GO:0032870

Cellular response to hormone stimulus

10 of 298

1.7

3.81

5.12e-13

GO:0009755

Hormone-mediated signaling pathway

6 of 81

2.05

3.58

1.26e-08

GO:0048384

Retinoic acid receptor signaling pathway

4 of 15

2.6

3.46

2.99e-07

GO:0033993

Response to lipid

7 of 375

1.45

2.01

5.83e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004879

Nuclear receptor activity

6 of 47

2.28

4.34

1.09e-09

GO:0016922

Nuclear receptor binding

6 of 114

1.9

3.18

3.55e-08

GO:0030374

Nuclear receptor coactivator activity

4 of 43

2.15

2.57

6.89e-06

GO:0061629

RNA polymerase II-specific DNA-binding transcription factor binding

7 of 283

1.57

2.45

7.24e-08

GO:0008134

Transcription factor binding

8 of 448

1.43

2.18

3.55e-08

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005667

Transcription regulator complex

6 of 405

1.35

1.37

0.00015

GO:0005654

Nucleoplasm

8 of 2921

0.61

0.36

0.0485

GO:0005634

Nucleus

11 of 6158

0.43

0.32

0.0148

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:20801112

(2010) Growth differentiation factor 11 signaling controls retinoic acid activity for axial vertebral development.

3 of 18

2.4

1.66

0.00079

PMID:33677245

(2021) Concentrations and endocrine disruptive potential of phthalates in marine mammals from the Norwegian Arctic.

2 of 2

3.18

1.38

0.0033

PMID:32212695

(2020) Environmental Pollutants Modulate Transcriptional Activity of Nuclear Receptors of Whales In Vitro.

2 of 2

3.18

1.38

0.0033

PMID:30681325

(2019) Perfluorinated Alkyl Acids in Hawaiian Cetaceans and Potential Biomarkers of Effect: Peroxisome Proliferator-Activated Receptor Alpha and Cytochrome P450 4A.

2 of 2

3.18

1.38

0.0033

PMID:34081971

(2021) Early-life associations between per- and polyfluoroalkyl substances and serum lipids in a longitudinal birth cohort.

2 of 4

2.88

1.37

0.0033

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4634

NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, and Ligand binding domain of hormone receptors

7 of 22

2.68

6.92

2.83e-14

CL:4398

Mixed, incl. Nuclear Receptor transcription pathway, and MAP kinase activation

9 of 191

1.85

4.42

3.06e-13

CL:4635

NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, and Thyroid hormone binding

4 of 17

2.55

3.38

3.90e-07

CL:4668

Retinoic acid receptor signaling pathway, and Retinol binding

3 of 5

2.96

2.84

6.49e-06

CL:4638

NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis, and Nuclear receptor coactivator

2 of 5

2.78

1.33

0.0039

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04919

Thyroid hormone signaling pathway

7 of 135

1.89

3.78

3.30e-10

map05200

Pathways in cancer

6 of 516

1.24

1.31

6.74e-05

map03320

PPAR signaling pathway

3 of 94

1.68

1.17

0.0036

map01522

Endocrine resistance

3 of 102

1.65

1.15

0.0036

map04915

Estrogen signaling pathway

3 of 125

1.56

1.06

0.0050

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-383280

Nuclear Receptor transcription pathway

8 of 57

2.32

6.42

1.00e-14

MAP-9006931

Signaling by Nuclear Receptors

8 of 248

1.69

3.21

3.93e-10

MAP-5362517

Signaling by Retinoic Acid

3 of 43

2.02

1.58

0.00079

MAP-9018519

Estrogen-dependent gene expression

4 of 124

1.69

1.55

0.00037

MAP-400206

Regulation of lipid metabolism by PPARalpha

3 of 52

1.94

1.47

0.0012

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005634

Nucleus

11 of 3065

0.73

0.68

1.62e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0010

Activator

5 of 42

2.25

4.04

4.58e-09

KW-0805

Transcription regulation

9 of 251

1.73

3.88

9.17e-13

KW-0539

Nucleus

10 of 796

1.28

2.05

8.41e-11

KW-0675

Receptor

9 of 761

1.25

1.84

4.16e-09

KW-0238

DNA-binding

5 of 512

1.17

1.04

0.00065

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16665

Unstructured region on nuclear receptor coactivator protein

3 of 3

3.18

2.79

9.00e-06

PF08832

Steroid receptor coactivator

3 of 3

3.18

2.79

9.00e-06

PF08815

Nuclear receptor coactivator

3 of 3

3.18

2.79

9.00e-06

PF16279

Domain of unknown function (DUF4927)

2 of 2

3.18

1.62

0.0012

PF14598

PAS domain

2 of 2

3.18

1.62

0.0012

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR037077

Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily

2 of 2

3.18

1.12

0.0096

IPR017426

Nuclear receptor coactivator

2 of 2

3.18

1.12

0.0096

IPR014935

Nuclear receptor coactivator, receptor-binding domain

2 of 2

3.18

1.12

0.0096

IPR014920

Nuclear receptor coactivator, Ncoa-type, interlocking

2 of 2

3.18

1.12

0.0096

IPR010011

Nuclear receptor coactivator, DUF1518

2 of 2

3.18

1.12

0.0096

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00430

Ligand binding domain of hormone receptors

6 of 45

2.3

4.65

2.22e-10

SM00399

c4 zinc finger in nuclear hormone receptors

5 of 41

2.26

3.75

2.33e-08

SM01151

This domain, which is usually found tandemly repeated, is found various receptor co-activating proteins.

3 of 3

3.18

3.28

1.12e-06

SM00091

PAS domain

3 of 28

2.21

1.93

0.00019

SM00353

Helix loop helix domain

3 of 90

1.7

1.15

0.0042

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About