AYL99_08647 protein (Fonsecaea erecta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

AYL99_08647

Uncharacterized protein. (911 aa)

Predicted Functional Partners:

AYL99_09823

0.759

AYL99_03706

0.616

AYL99_06322

0.605

AYL99_08301

0.511

AYL99_07157

0.500

AYL99_00702

0.500

AYL99_09580

0.494

AYL99_08663

0.494

AYL99_06902

0.494

AYL99_05567

0.494

Your Current Organism:

Fonsecaea erecta

NCBI taxonomy Id: 1367422
Other names: F. erecta, Fonsecaea erecta V. A. Vicente, Najafzadeh, Sun & de Hoog 2013, Fonsecaea sp. RG-2013a

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AYL99_00702	AYL99_03706	A0A178ZXZ7	A0A178ZQP1	Uncharacterized protein.	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.676
AYL99_00702	AYL99_07157	A0A178ZXZ7	A0A178ZE66	Uncharacterized protein.	Uncharacterized protein.	0.966
AYL99_00702	AYL99_08647	A0A178ZXZ7	A0A178ZDQ6	Uncharacterized protein.	Uncharacterized protein.	0.500
AYL99_03706	AYL99_00702	A0A178ZQP1	A0A178ZXZ7	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	Uncharacterized protein.	0.676
AYL99_03706	AYL99_06322	A0A178ZQP1	A0A178ZJ05	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.450
AYL99_03706	AYL99_07157	A0A178ZQP1	A0A178ZE66	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	Uncharacterized protein.	0.771
AYL99_03706	AYL99_08647	A0A178ZQP1	A0A178ZDQ6	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	Uncharacterized protein.	0.616
AYL99_05567	AYL99_06322	A0A178ZNI0	A0A178ZJ05	Carrier domain-containing protein.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.923
AYL99_05567	AYL99_08301	A0A178ZNI0	A0A178ZEF7	Carrier domain-containing protein.	Tryptophan synthase.	0.925
AYL99_05567	AYL99_08647	A0A178ZNI0	A0A178ZDQ6	Carrier domain-containing protein.	Uncharacterized protein.	0.494
AYL99_06322	AYL99_03706	A0A178ZJ05	A0A178ZQP1	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.450
AYL99_06322	AYL99_05567	A0A178ZJ05	A0A178ZNI0	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	Carrier domain-containing protein.	0.923
AYL99_06322	AYL99_06902	A0A178ZJ05	A0A178ZIJ5	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	L-aminoadipate-semialdehyde dehydrogenase.	0.923
AYL99_06322	AYL99_08647	A0A178ZJ05	A0A178ZDQ6	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	Uncharacterized protein.	0.605
AYL99_06322	AYL99_08663	A0A178ZJ05	A0A178ZFU1	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	4-carboxymuconolactone decarboxylase.	0.923
AYL99_06322	AYL99_09580	A0A178ZJ05	A0A178ZAA9	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	Carrier domain-containing protein.	0.923
AYL99_06322	AYL99_09823	A0A178ZJ05	A0A178Z852	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	0.495
AYL99_06902	AYL99_06322	A0A178ZIJ5	A0A178ZJ05	L-aminoadipate-semialdehyde dehydrogenase.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.923
AYL99_06902	AYL99_08301	A0A178ZIJ5	A0A178ZEF7	L-aminoadipate-semialdehyde dehydrogenase.	Tryptophan synthase.	0.925
AYL99_06902	AYL99_08647	A0A178ZIJ5	A0A178ZDQ6	L-aminoadipate-semialdehyde dehydrogenase.	Uncharacterized protein.	0.494

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

12

average node degree:

2.18

avg. local clustering coefficient:

0.883

expected number of edges:

13

PPI enrichment p-value:

0.649

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030509

BMP signaling pathway

7 of 81

2.19

4.81

3.05e-11

GO:0045667

Regulation of osteoblast differentiation

7 of 91

2.14

4.64

4.63e-11

GO:0090092

Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

9 of 201

1.91

4.53

8.00e-13

GO:0030500

Regulation of bone mineralization

6 of 58

2.27

4.45

5.40e-10

GO:0009953

Dorsal/ventral pattern formation

6 of 66

2.22

4.26

9.98e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004675

Transmembrane receptor protein serine/threonine kinase activity

6 of 17

2.81

6.21

1.58e-12

GO:0036122

BMP binding

6 of 20

2.73

6.12

1.80e-12

GO:0019955

Cytokine binding

7 of 128

2.0

4.11

1.78e-10

GO:0005024

Transforming growth factor beta receptor activity

4 of 10

2.86

4.06

2.96e-08

GO:0098821

BMP receptor activity

3 of 6

2.96

2.9

5.16e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0048179

Activin receptor complex

3 of 7

2.89

2.6

1.74e-05

GO:0043235

Receptor complex

6 of 340

1.5

1.78

1.74e-05

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37300483

(2024) BMP7 expression in mammalian cortical radial glial cells increases the length of the neurogenic period.

4 of 49

2.17

2.21

4.51e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:16804

Signaling by BMP, and Transforming growth factor beta, conserved site

11 of 54

2.57

11.08

7.90e-25

CL:16864

TGF-beta propeptide, and BMP receptor activity

9 of 24

2.83

10.58

1.35e-21

CL:16865

TGF-beta propeptide, and Transforming growth factor beta receptor activity, type I

8 of 18

2.91

9.64

2.58e-19

CL:16867

TGF-beta propeptide, and Transforming growth factor beta receptor activity, type I

5 of 13

2.84

5.38

8.16e-11

CL:16855

Activin receptor complex, and Negative regulation of myoblast proliferation

2 of 5

2.86

1.41

0.0028

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04350

TGF-beta signaling pathway

11 of 108

2.27

8.86

7.53e-23

map04060

Cytokine-cytokine receptor interaction

7 of 285

1.65

2.84

7.43e-09

map05418

Fluid shear stress and atherosclerosis

5 of 151

1.78

2.47

1.43e-06

map04550

Signaling pathways regulating pluripotency of stem cells

5 of 154

1.77

2.46

1.43e-06

map04390

Hippo signaling pathway

4 of 166

1.64

1.7

0.00011

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-201451

Signaling by BMP

7 of 26

2.69

7.15

9.63e-15

MAP-9006936

Signaling by TGFB family members

8 of 122

2.07

5.17

3.64e-13

MAP-1502540

Signaling by Activin

2 of 14

2.41

1.01

0.0140

MAP-162582

Signal Transduction

8 of 2927

0.69

0.47

0.0135

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0048179

Activin receptor complex

3 of 5

3.04

2.95

4.19e-06

GOCC:0070724

BMP receptor complex

3 of 6

2.96

2.92

4.72e-06

GOCC:0098802

Plasma membrane signaling receptor complex

6 of 182

1.78

2.61

5.21e-07

GOCC:0005887

Integral component of plasma membrane

6 of 408

1.43

1.71

1.18e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0723

Serine/threonine-protein kinase

6 of 190

1.76

2.76

1.28e-07

KW-0464

Manganese

3 of 54

2.0

1.8

0.00025

KW-0964

Secreted

4 of 266

1.43

1.32

0.00050

KW-0460

Magnesium

3 of 128

1.63

1.27

0.0017

KW-0067

ATP-binding

6 of 781

1.14

1.11

0.00017

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01064

Activin types I and II receptor domain

5 of 8

3.05

5.59

4.92e-11

PF00069

Protein kinase domain

3 of 34

2.2

1.58

0.0010

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000333

Ser/Thr protein kinase, TGFB receptor

6 of 12

2.96

6.51

6.74e-13

IPR000472

Activin types I and II receptor domain

5 of 10

2.96

5.34

1.21e-10

IPR045860

Snake toxin-like superfamily

6 of 36

2.48

5.04

9.47e-11

IPR029034

Cystine-knot cytokine

4 of 63

2.06

2.09

6.47e-05

IPR017159

Gremlin-1/2

2 of 2

3.26

1.55

0.0016

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00467

GS motif

2 of 7

2.71

1.16

0.0079

SM00041

C-terminal cystine knot-like domain (CTCK)

2 of 17

2.33

0.94

0.0187

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About