AYL99_05629 protein (Fonsecaea erecta) - STRING interaction network

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second shell of interactors

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filled nodes:
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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

AYL99_05629

Uncharacterized protein. (426 aa)

Predicted Functional Partners:

AYL99_09391

0.737

AYL99_00077

0.676

AYL99_05460

0.673

AYL99_11549

0.645

AYL99_05381

0.640

AYL99_09202

0.625

AYL99_10185

0.622

AYL99_10952

0.618

AYL99_04836

0.594

AYL99_03833

0.591

Your Current Organism:

Fonsecaea erecta

NCBI taxonomy Id: 1367422
Other names: F. erecta, Fonsecaea erecta V. A. Vicente, Najafzadeh, Sun & de Hoog 2013, Fonsecaea sp. RG-2013a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AYL99_00077	AYL99_03833	A0A178ZYK5	A0A178ZP95	WD_REPEATS_REGION domain-containing protein.	UBA domain-containing protein.	0.757
AYL99_00077	AYL99_05460	A0A178ZYK5	A0A178ZKY5	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.999
AYL99_00077	AYL99_05629	A0A178ZYK5	A0A178ZLH1	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.676
AYL99_03833	AYL99_00077	A0A178ZP95	A0A178ZYK5	UBA domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.757
AYL99_03833	AYL99_05460	A0A178ZP95	A0A178ZKY5	UBA domain-containing protein.	Uncharacterized protein.	0.740
AYL99_03833	AYL99_05629	A0A178ZP95	A0A178ZLH1	UBA domain-containing protein.	Uncharacterized protein.	0.591
AYL99_03833	AYL99_09202	A0A178ZP95	A0A178ZBE4	UBA domain-containing protein.	Protein transporter sec13; Belongs to the WD repeat SEC13 family.	0.407
AYL99_04836	AYL99_05381	A0A178ZJ72	A0A178ZKQ6	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	Uncharacterized protein.	0.999
AYL99_04836	AYL99_05629	A0A178ZJ72	A0A178ZLH1	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	Uncharacterized protein.	0.594
AYL99_04836	AYL99_09202	A0A178ZJ72	A0A178ZBE4	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	Protein transporter sec13; Belongs to the WD repeat SEC13 family.	0.999
AYL99_04836	AYL99_09391	A0A178ZJ72	A0A178Z969	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	RanBD1 domain-containing protein.	0.999
AYL99_04836	AYL99_10952	A0A178ZJ72	A0A178Z440	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	WD_REPEATS_REGION domain-containing protein.	0.986
AYL99_04836	AYL99_11549	A0A178ZJ72	A0A178Z3Y3	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	0.999
AYL99_05381	AYL99_04836	A0A178ZKQ6	A0A178ZJ72	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	0.999
AYL99_05381	AYL99_05629	A0A178ZKQ6	A0A178ZLH1	Uncharacterized protein.	Uncharacterized protein.	0.640
AYL99_05381	AYL99_09202	A0A178ZKQ6	A0A178ZBE4	Uncharacterized protein.	Protein transporter sec13; Belongs to the WD repeat SEC13 family.	0.999
AYL99_05381	AYL99_09391	A0A178ZKQ6	A0A178Z969	Uncharacterized protein.	RanBD1 domain-containing protein.	0.999
AYL99_05381	AYL99_10952	A0A178ZKQ6	A0A178Z440	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.999
AYL99_05381	AYL99_11549	A0A178ZKQ6	A0A178Z3Y3	Uncharacterized protein.	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	0.999
AYL99_05460	AYL99_00077	A0A178ZKY5	A0A178ZYK5	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.999

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.846

expected number of edges:

16

PPI enrichment p-value:

1.71e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042537

Benzene-containing compound metabolic process

8 of 12

2.82

8.69

1.34e-17

GO:0006569

Tryptophan catabolic process

7 of 7

2.99

8.13

4.93e-16

GO:0034354

De novo NAD biosynthetic process from tryptophan

7 of 9

2.88

8.02

4.93e-16

GO:0043420

Anthranilate metabolic process

5 of 5

2.99

5.9

1.09e-11

GO:0019805

Quinolinate biosynthetic process

5 of 5

2.99

5.9

1.09e-11

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004502

Kynurenine 3-monooxygenase activity

3 of 3

2.99

2.56

2.21e-05

GO:0016702

Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

3 of 12

2.39

2.0

0.00017

GO:0033754

Indoleamine 2,3-dioxygenase activity

2 of 2

2.99

1.6

0.0013

GO:0003882

CDP-diacylglycerol-serine O-phosphatidyltransferase activity

2 of 3

2.82

1.55

0.0015

GO:0071949

FAD binding

3 of 37

1.9

1.44

0.0013

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005741

Mitochondrial outer membrane

3 of 49

1.78

0.97

0.0123

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9771

Mixed, incl. Lipid biosynthetic process, and Tryptophan catabolism

10 of 172

1.76

4.28

2.15e-14

CL:9973

Amine catabolic process

4 of 5

2.9

4.11

2.57e-08

CL:9773

Mixed, incl. Steroid biosynthetic process, and Tryptophan catabolism

8 of 108

1.86

4.06

1.55e-11

CL:10041

Phosphatidylserine metabolic process, and Synthesis of CL

2 of 7

2.45

1.13

0.0085

CL:9779

Steroid biosynthetic process, and Tryptophan catabolism

3 of 60

1.69

1.02

0.0085

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00380

Tryptophan metabolism

8 of 42

2.27

6.48

2.63e-15

map01100

Metabolic pathways

11 of 1981

0.74

0.73

5.59e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-71240

Tryptophan catabolism

11 of 24

2.65

11.89

6.26e-26

MAP-71291

Metabolism of amino acids and derivatives

11 of 236

1.66

4.1

3.13e-16

MAP-1430728

Metabolism

11 of 1327

0.91

1.04

2.96e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005741

Mitochondrial outer membrane

3 of 64

1.66

0.89

0.0161

GOCC:0005737

Cytoplasm

11 of 2575

0.62

0.54

0.00013

GOCC:0005739

Mitochondrion

5 of 623

0.9

0.49

0.0398

GOCC:0031090

Organelle membrane

5 of 695

0.85

0.46

0.0473

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0662

Pyridine nucleotide biosynthesis

3 of 5

2.77

2.88

4.80e-06

KW-0223

Dioxygenase

3 of 12

2.39

2.41

2.59e-05

KW-0560

Oxidoreductase

6 of 145

1.61

2.31

6.39e-07

KW-1000

Mitochondrion outer membrane

2 of 5

2.6

1.67

0.00087

KW-0503

Monooxygenase

3 of 37

1.9

1.66

0.00042

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01494

FAD binding domain

3 of 4

2.87

2.49

2.85e-05

PF01231

Indoleamine 2,3-dioxygenase

2 of 3

2.82

1.27

0.0049

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002938

FAD-binding domain

3 of 4

2.87

2.24

8.17e-05

IPR037217

Tryptophan/Indoleamine 2,3-dioxygenase-like

2 of 3

2.82

1.15

0.0084

IPR027545

Kynurenine 3-monooxygenase

2 of 2

2.99

1.15

0.0084

IPR000898

Indoleamine 2,3-dioxygenase

2 of 3

2.82

1.15

0.0084

IPR036188

FAD/NAD(P)-binding domain superfamily

3 of 34

1.94

1.07

0.0084

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