AYL99_01911 protein (Fonsecaea erecta) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Score

AYL99_01911

26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (903 aa)

Predicted Functional Partners:

AYL99_10819

0.999

AYL99_10477

0.999

AYL99_09636

0.999

AYL99_08649

0.999

AYL99_07607

0.999

AYL99_07640

0.999

AYL99_06625

0.999

AYL99_06801

0.999

AYL99_04903

0.999

AYL99_05310

0.999

Your Current Organism:

Fonsecaea erecta

NCBI taxonomy Id: 1367422
Other names: F. erecta, Fonsecaea erecta V. A. Vicente, Najafzadeh, Sun & de Hoog 2013, Fonsecaea sp. RG-2013a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AYL99_01911	AYL99_04903	A0A178ZS79	A0A178ZK91	26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	Proteasome subunit alpha type.	0.999
AYL99_01911	AYL99_05310	A0A178ZS79	A0A178ZKI2	26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	26S protease regulatory subunit 8; Belongs to the AAA ATPase family.	0.999
AYL99_01911	AYL99_06625	A0A178ZS79	A0A178ZHP3	26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	26S protease regulatory subunit 6A; Belongs to the AAA ATPase family.	0.999
AYL99_01911	AYL99_06801	A0A178ZS79	A0A178ZJY7	26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	Proteasome component PUP1.	0.999
AYL99_01911	AYL99_07607	A0A178ZS79	A0A178ZFG0	26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	PCI domain-containing protein.	0.999
AYL99_01911	AYL99_07640	A0A178ZS79	A0A178ZFI9	26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	PCI domain-containing protein.	0.999
AYL99_01911	AYL99_08649	A0A178ZS79	A0A178ZEJ2	26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	26S proteasome regulatory subunit rpn-8.	0.999
AYL99_01911	AYL99_09636	A0A178ZS79	A0A178Z9K0	26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	PCI domain-containing protein.	0.999
AYL99_01911	AYL99_10477	A0A178ZS79	A0A178Z6W0	26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	Proteasome subunit alpha type.	0.999
AYL99_01911	AYL99_10819	A0A178ZS79	A0A178Z5S9	26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	26S proteasome regulatory subunit RPN2; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	0.999
AYL99_04903	AYL99_01911	A0A178ZK91	A0A178ZS79	Proteasome subunit alpha type.	26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	0.999
AYL99_04903	AYL99_05310	A0A178ZK91	A0A178ZKI2	Proteasome subunit alpha type.	26S protease regulatory subunit 8; Belongs to the AAA ATPase family.	0.998
AYL99_04903	AYL99_06625	A0A178ZK91	A0A178ZHP3	Proteasome subunit alpha type.	26S protease regulatory subunit 6A; Belongs to the AAA ATPase family.	0.999
AYL99_04903	AYL99_06801	A0A178ZK91	A0A178ZJY7	Proteasome subunit alpha type.	Proteasome component PUP1.	0.999
AYL99_04903	AYL99_07607	A0A178ZK91	A0A178ZFG0	Proteasome subunit alpha type.	PCI domain-containing protein.	0.999
AYL99_04903	AYL99_07640	A0A178ZK91	A0A178ZFI9	Proteasome subunit alpha type.	PCI domain-containing protein.	0.852
AYL99_04903	AYL99_08649	A0A178ZK91	A0A178ZEJ2	Proteasome subunit alpha type.	26S proteasome regulatory subunit rpn-8.	0.999
AYL99_04903	AYL99_09636	A0A178ZK91	A0A178Z9K0	Proteasome subunit alpha type.	PCI domain-containing protein.	0.999
AYL99_04903	AYL99_10477	A0A178ZK91	A0A178Z6W0	Proteasome subunit alpha type.	Proteasome subunit alpha type.	0.999
AYL99_04903	AYL99_10819	A0A178ZK91	A0A178Z5S9	Proteasome subunit alpha type.	26S proteasome regulatory subunit RPN2; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	0.997

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Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.77

expected number of edges:

10

PPI enrichment p-value:

4.01e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044718

Siderophore transmembrane transport

5 of 20

1.91

2.51

3.22e-06

GO:0006811

Ion transport

9 of 188

1.19

1.54

2.55e-07

GO:0071702

Organic substance transport

7 of 213

1.03

1.0

9.66e-05

GO:0006810

Transport

10 of 501

0.81

0.79

8.34e-06

GO:0055085

Transmembrane transport

7 of 381

0.78

0.59

0.0027

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031992

Energy transducer activity

4 of 4

2.51

3.12

1.20e-06

GO:0060089

Molecular transducer activity

6 of 31

1.8

2.74

2.53e-07

GO:0015343

Siderophore transmembrane transporter activity

5 of 25

1.81

2.41

3.09e-06

GO:0022857

Transmembrane transporter activity

9 of 371

0.9

1.26e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030313

Cell envelope

9 of 140

1.32

2.05

2.15e-09

GO:0009279

Cell outer membrane

6 of 113

1.24

1.38

2.28e-05

GO:0030288

Outer membrane-bounded periplasmic space

3 of 26

1.57

1.26

0.0015

GO:0071944

Cell periphery

10 of 665

0.69

0.63

2.28e-05

GO:0016020

Membrane

10 of 1191

0.44

0.35

0.0024

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37425997

(2023) Polymeric carbohydrates utilization separates microbiomes into niches: insights into the diversity of microbial carbohydrate-active enzymes in the inner shelf of the Pearl River Estuary, China.

2 of 3

2.34

1.51

0.0015

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4462

Mixed, incl. TonB-dependent receptor-like, beta-barrel domain superfamily, and Sulfotransferase family

9 of 110

1.42

2.36

1.54e-09

CL:4472

TonB box, and S-adenosyl-L-methionine dependent methyltransferase, Alr7345, predicted

6 of 57

1.53

2.14

9.05e-07

CL:4475

TonB box

4 of 28

1.67

1.75

9.62e-05

CL:4660

Mixed, incl. Periplasmic binding protein, and Bacterial microcompartment

3 of 11

1.95

1.68

0.00042

CL:4478

TonB box

3 of 20

1.69

1.29

0.0018

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009279

Cell outer membrane

5 of 103

1.2

0.93

0.0027

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0798

TonB box

6 of 55

1.55

2.09

1.78e-06

KW-0675

Receptor

5 of 43

1.58

1.89

1.65e-05

KW-0998

Cell outer membrane

5 of 66

1.39

1.48

8.09e-05

KW-0735

Signal-anchor

2 of 4

2.21

1.21

0.0055

KW-1134

Transmembrane beta strand

3 of 43

1.36

0.85

0.0110

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07715

TonB-dependent Receptor Plug Domain

6 of 57

1.53

1.95

5.80e-06

PF03544

Gram-negative bacterial TonB protein C-terminal

3 of 5

2.29

1.91

0.00023

PF00593

TonB dependent receptor

5 of 50

1.51

1.61

8.84e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039426

TonB-dependent receptor-like

6 of 40

1.69

2.29

2.10e-06

IPR000531

TonB-dependent receptor-like, beta-barrel

6 of 55

1.55

1.96

6.12e-06

IPR012910

TonB-dependent receptor, plug domain

6 of 57

1.53

1.94

6.12e-06

IPR036942

TonB-dependent receptor-like, beta-barrel domain superfamily

6 of 65

1.48

1.83

7.80e-06

IPR037682

TonB, C-terminal

3 of 5

2.29

1.82

0.00036

(more ...)

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