AYL99_00665 protein (Fonsecaea erecta) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

AYL99_00665

RING-type domain-containing protein. (703 aa)

Predicted Functional Partners:

AYL99_00702

0.664

AYL99_08721

0.455

AYL99_04049

0.455

AYL99_00851

0.455

AYL99_06350

0.446

AYL99_08100

0.439

COQ5

0.431

AYL99_10476

0.430

AYL99_06527

0.430

AYL99_03376

0.430

Your Current Organism:

Fonsecaea erecta

NCBI taxonomy Id: 1367422
Other names: F. erecta, Fonsecaea erecta V. A. Vicente, Najafzadeh, Sun & de Hoog 2013, Fonsecaea sp. RG-2013a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AYL99_00665	AYL99_00702	A0A178ZZT7	A0A178ZXZ7	RING-type domain-containing protein.	Uncharacterized protein.	0.664
AYL99_00665	AYL99_00851	A0A178ZZT7	A0A178ZYK6	RING-type domain-containing protein.	Uncharacterized protein.	0.455
AYL99_00665	AYL99_03376	A0A178ZZT7	A0A178ZQ89	RING-type domain-containing protein.	Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	0.430
AYL99_00665	AYL99_04049	A0A178ZZT7	A0A178ZR48	RING-type domain-containing protein.	Uncharacterized protein.	0.455
AYL99_00665	AYL99_06350	A0A178ZZT7	A0A178ZHD6	RING-type domain-containing protein.	Uncharacterized protein.	0.446
AYL99_00665	AYL99_06527	A0A178ZZT7	A0A178ZHE4	RING-type domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.430
AYL99_00665	AYL99_08100	A0A178ZZT7	A0A178ZCH0	RING-type domain-containing protein.	MPN domain-containing protein.	0.439
AYL99_00665	AYL99_08721	A0A178ZZT7	A0A178ZA17	RING-type domain-containing protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.455
AYL99_00665	AYL99_10476	A0A178ZZT7	A0A178Z8J9	RING-type domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.430
AYL99_00665	COQ5	A0A178ZZT7	A0A178Z8Z2	RING-type domain-containing protein.	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2).	0.431
AYL99_00702	AYL99_00665	A0A178ZXZ7	A0A178ZZT7	Uncharacterized protein.	RING-type domain-containing protein.	0.664
AYL99_00851	AYL99_00665	A0A178ZYK6	A0A178ZZT7	Uncharacterized protein.	RING-type domain-containing protein.	0.455
AYL99_00851	AYL99_06350	A0A178ZYK6	A0A178ZHD6	Uncharacterized protein.	Uncharacterized protein.	0.912
AYL99_03376	AYL99_00665	A0A178ZQ89	A0A178ZZT7	Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	RING-type domain-containing protein.	0.430
AYL99_03376	AYL99_04049	A0A178ZQ89	A0A178ZR48	Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	Uncharacterized protein.	0.457
AYL99_03376	AYL99_06350	A0A178ZQ89	A0A178ZHD6	Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	Uncharacterized protein.	0.776
AYL99_03376	AYL99_06527	A0A178ZQ89	A0A178ZHE4	Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.475
AYL99_03376	AYL99_08100	A0A178ZQ89	A0A178ZCH0	Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	MPN domain-containing protein.	0.492
AYL99_03376	AYL99_08721	A0A178ZQ89	A0A178ZA17	Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.457
AYL99_03376	AYL99_10476	A0A178ZQ89	A0A178Z8J9	Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.678

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Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.781

expected number of edges:

11

PPI enrichment p-value:

0.00014

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000096

Sulfur amino acid metabolic process

6 of 18

1.99

3.28

4.67e-08

GO:0000097

Sulfur amino acid biosynthetic process

5 of 13

2.05

2.89

7.98e-07

GO:0006534

Cysteine metabolic process

4 of 9

2.11

2.39

1.56e-05

GO:1901607

Alpha-amino acid biosynthetic process

6 of 103

1.23

1.27

8.95e-05

GO:1901605

Alpha-amino acid metabolic process

7 of 147

1.14

1.21

3.34e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030170

Pyridoxal phosphate binding

4 of 28

1.62

1.28

0.0016

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2328

Cysteine and methionine metabolism, and L-serine metabolic process

5 of 20

1.86

2.47

3.00e-06

CL:2329

Cys/Met metabolism, pyridoxal phosphate-dependent enzyme, and Cysteine and methionine metabolism

4 of 11

2.02

2.31

1.79e-05

CL:2332

Sulfur amino acid biosynthetic process, and Potassium

3 of 5

2.24

1.93

0.00020

CL:2257

Glycine, serine and threonine metabolism, and Sulfur amino acid metabolic process

6 of 64

1.44

1.76

8.74e-06

CL:2105

Alpha-amino acid metabolic process, and Glycine, serine and threonine metabolism

8 of 140

1.22

1.5

1.77e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00270

Cysteine and methionine metabolism

8 of 41

1.75

3.65

3.23e-11

map01230

Biosynthesis of amino acids

8 of 154

1.18

1.5

3.21e-07

map00450

Selenocompound metabolism

3 of 18

1.69

1.4

0.00096

map00920

Sulfur metabolism

3 of 38

1.36

0.94

0.0062

map00260

Glycine, serine and threonine metabolism

3 of 67

1.11

0.63

0.0258

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00291

Pyridoxal-phosphate dependent enzyme

3 of 5

2.24

1.65

0.00074

PF01842

ACT domain

2 of 5

2.07

0.7

0.0497

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001926

Tryptophan synthase beta chain-like, PALP domain

3 of 5

2.24

1.42

0.0021

IPR036052

Tryptophan synthase beta chain-like, PALP domain superfamily

3 of 6

2.16

1.41

0.0021

IPR001216

Cysteine synthase/cystathionine beta-synthase, pyridoxal-phosphate attachment site

2 of 2

2.46

0.86

0.0265

IPR015422

Pyridoxal phosphate-dependent transferase, small domain

3 of 25

1.54

0.75

0.0291

IPR015424

Pyridoxal phosphate-dependent transferase

3 of 27

1.51

0.74

0.0291

(more ...)

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