AYL99_01622 protein (Fonsecaea erecta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

AYL99_01622

Uncharacterized protein. (525 aa)

Predicted Functional Partners:

AYL99_11455

0.534

AYL99_08636

0.533

AYL99_07268

0.439

AYL99_07272

0.439

AYL99_07273

0.439

AYL99_03899

0.439

AYL99_02388

0.439

AYL99_01546

0.439

AYL99_01589

0.439

AYL99_01545

0.439

Your Current Organism:

Fonsecaea erecta

NCBI taxonomy Id: 1367422
Other names: F. erecta, Fonsecaea erecta V. A. Vicente, Najafzadeh, Sun & de Hoog 2013, Fonsecaea sp. RG-2013a

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AYL99_01545	AYL99_01589	A0A179A2F3	A0A179A0V0	Uncharacterized protein.	Shikimate_dh_N domain-containing protein.	0.748
AYL99_01545	AYL99_01622	A0A179A2F3	A0A179A0H2	Uncharacterized protein.	Uncharacterized protein.	0.439
AYL99_01545	AYL99_03899	A0A179A2F3	A0A178ZQP7	Uncharacterized protein.	DHQ_synthase domain-containing protein.	0.763
AYL99_01545	AYL99_07272	A0A179A2F3	A0A178ZEW8	Uncharacterized protein.	Shikimate-5-dehydrogenase.	0.753
AYL99_01545	AYL99_08636	A0A179A2F3	A0A178ZDQ8	Uncharacterized protein.	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	0.906
AYL99_01546	AYL99_01622	A0A179A0B5	A0A179A0H2	AP_endonuc_2 domain-containing protein.	Uncharacterized protein.	0.439
AYL99_01546	AYL99_07272	A0A179A0B5	A0A178ZEW8	AP_endonuc_2 domain-containing protein.	Shikimate-5-dehydrogenase.	0.462
AYL99_01546	AYL99_08636	A0A179A0B5	A0A178ZDQ8	AP_endonuc_2 domain-containing protein.	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	0.906
AYL99_01589	AYL99_01545	A0A179A0V0	A0A179A2F3	Shikimate_dh_N domain-containing protein.	Uncharacterized protein.	0.748
AYL99_01589	AYL99_01622	A0A179A0V0	A0A179A0H2	Shikimate_dh_N domain-containing protein.	Uncharacterized protein.	0.439
AYL99_01589	AYL99_02388	A0A179A0V0	A0A178ZUN8	Shikimate_dh_N domain-containing protein.	3-phosphoshikimate 1-carboxyvinyltransferase; The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis. In the 2nd section; belongs to the EPSP synthase family. In the 4th section; belongs to the type-I 3-dehydroquinase family. In the N-terminal section; belongs to the dehydroquinate synthase family.	0.749
AYL99_01589	AYL99_03899	A0A179A0V0	A0A178ZQP7	Shikimate_dh_N domain-containing protein.	DHQ_synthase domain-containing protein.	0.739
AYL99_01589	AYL99_08636	A0A179A0V0	A0A178ZDQ8	Shikimate_dh_N domain-containing protein.	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	0.906
AYL99_01622	AYL99_01545	A0A179A0H2	A0A179A2F3	Uncharacterized protein.	Uncharacterized protein.	0.439
AYL99_01622	AYL99_01546	A0A179A0H2	A0A179A0B5	Uncharacterized protein.	AP_endonuc_2 domain-containing protein.	0.439
AYL99_01622	AYL99_01589	A0A179A0H2	A0A179A0V0	Uncharacterized protein.	Shikimate_dh_N domain-containing protein.	0.439
AYL99_01622	AYL99_02388	A0A179A0H2	A0A178ZUN8	Uncharacterized protein.	3-phosphoshikimate 1-carboxyvinyltransferase; The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis. In the 2nd section; belongs to the EPSP synthase family. In the 4th section; belongs to the type-I 3-dehydroquinase family. In the N-terminal section; belongs to the dehydroquinate synthase family.	0.439
AYL99_01622	AYL99_03899	A0A179A0H2	A0A178ZQP7	Uncharacterized protein.	DHQ_synthase domain-containing protein.	0.439
AYL99_01622	AYL99_07268	A0A179A0H2	A0A178ZEI1	Uncharacterized protein.	AP_endonuc_2 domain-containing protein.	0.439
AYL99_01622	AYL99_07272	A0A179A0H2	A0A178ZEW8	Uncharacterized protein.	Shikimate-5-dehydrogenase.	0.439

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.46

expected number of edges:

10

PPI enrichment p-value:

1.13e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006396

RNA processing

6 of 91

1.7

2.37

1.24e-06

GO:0034470

ncRNA processing

5 of 75

1.7

2.06

1.40e-05

GO:0008033

tRNA processing

4 of 56

1.73

1.71

0.00017

GO:0009451

RNA modification

4 of 58

1.72

1.7

0.00017

GO:0006364

rRNA processing

3 of 21

2.03

1.67

0.00050

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

5 of 134

1.45

1.36

0.00040

GO:0140098

Catalytic activity, acting on RNA

5 of 154

1.39

1.3

0.00040

GO:0008649

rRNA methyltransferase activity

2 of 6

2.4

1.18

0.0068

GO:0051539

4 iron, 4 sulfur cluster binding

3 of 43

1.72

1.13

0.0049

GO:0000049

tRNA binding

2 of 25

1.78

0.8

0.0282

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 1478

0.71

0.64

5.18e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2315

Mixed, incl. tRNA processing, and NusB family

4 of 21

2.16

2.28

3.19e-05

CL:2316

Mixed, incl. NusB family, and Methylthiotransferase

3 of 12

2.28

1.73

0.00053

CL:1849

Translation, and Ribosome biogenesis

5 of 142

1.42

1.3

0.00053

CL:2073

Mixed, incl. TGS-like, and RF-1 domain

2 of 6

2.4

1.02

0.0137

CL:2110

3-5 exonuclease, and S1 domain

2 of 8

2.28

0.94

0.0183

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005829

Cytosol

5 of 399

0.98

0.59

0.0210

GOCC:0005737

Cytoplasm

7 of 1152

0.66

0.43

0.0210

GOCC:0005622

Intracellular

9 of 1930

0.55

0.37

0.0210

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0698

rRNA processing

3 of 13

2.24

2.15

7.19e-05

KW-0949

S-adenosyl-L-methionine

4 of 52

1.76

1.89

6.65e-05

KW-0963

Cytoplasm

7 of 238

1.35

1.76

1.20e-06

KW-0819

tRNA processing

3 of 28

1.91

1.65

0.00043

KW-0004

4Fe-4S

3 of 39

1.76

1.46

0.00087

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR007197

Radical SAM

3 of 24

1.97

1.06

0.0094

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00729

Elongator protein 3, MiaB family, Radical SAM

3 of 18

2.1

1.78

0.00034

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (22%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About