node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGX02138.1 | AGX03926.1 | N288_00600 | N288_10040 | ATP-dependent Clp protease ATP-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the ClpA/ClpB family. | Translocation-enhancing protein TepA; Derived by automated computational analysis using gene prediction method: GeneMarkS+. | 0.833 |
AGX02138.1 | AGX06697.1 | N288_00600 | N288_24310 | ATP-dependent Clp protease ATP-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the ClpA/ClpB family. | Actin; Derived by automated computational analysis using gene prediction method: GeneMarkS+. | 0.902 |
AGX02138.1 | clpP | N288_00600 | N288_21640 | ATP-dependent Clp protease ATP-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.895 |
AGX02138.1 | clpP-2 | N288_00600 | N288_24205 | ATP-dependent Clp protease ATP-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.854 |
AGX02138.1 | dnaJ | N288_00600 | N288_18480 | ATP-dependent Clp protease ATP-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.777 |
AGX02138.1 | dnaK | N288_00600 | N288_18485 | ATP-dependent Clp protease ATP-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.911 |
AGX02138.1 | grpE | N288_00600 | N288_18490 | ATP-dependent Clp protease ATP-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the ClpA/ClpB family. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.799 |
AGX02138.1 | hrcA | N288_00600 | N288_18495 | ATP-dependent Clp protease ATP-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the ClpA/ClpB family. | HrcA family transcriptional regulator; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.612 |
AGX03926.1 | AGX02138.1 | N288_10040 | N288_00600 | Translocation-enhancing protein TepA; Derived by automated computational analysis using gene prediction method: GeneMarkS+. | ATP-dependent Clp protease ATP-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the ClpA/ClpB family. | 0.833 |
AGX03926.1 | AGX06697.1 | N288_10040 | N288_24310 | Translocation-enhancing protein TepA; Derived by automated computational analysis using gene prediction method: GeneMarkS+. | Actin; Derived by automated computational analysis using gene prediction method: GeneMarkS+. | 0.597 |
AGX03926.1 | dnaJ | N288_10040 | N288_18480 | Translocation-enhancing protein TepA; Derived by automated computational analysis using gene prediction method: GeneMarkS+. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.527 |
AGX03926.1 | dnaK | N288_10040 | N288_18485 | Translocation-enhancing protein TepA; Derived by automated computational analysis using gene prediction method: GeneMarkS+. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.636 |
AGX03926.1 | grpE | N288_10040 | N288_18490 | Translocation-enhancing protein TepA; Derived by automated computational analysis using gene prediction method: GeneMarkS+. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.619 |
AGX03926.1 | hrcA | N288_10040 | N288_18495 | Translocation-enhancing protein TepA; Derived by automated computational analysis using gene prediction method: GeneMarkS+. | HrcA family transcriptional regulator; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.712 |
AGX05580.1 | grpE | N288_18500 | N288_18490 | Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.488 |
AGX05580.1 | hrcA | N288_18500 | N288_18495 | Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | HrcA family transcriptional regulator; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.628 |
AGX05580.1 | lepA | N288_18500 | N288_18505 | Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 0.735 |
AGX06697.1 | AGX02138.1 | N288_24310 | N288_00600 | Actin; Derived by automated computational analysis using gene prediction method: GeneMarkS+. | ATP-dependent Clp protease ATP-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the ClpA/ClpB family. | 0.902 |
AGX06697.1 | AGX03926.1 | N288_24310 | N288_10040 | Actin; Derived by automated computational analysis using gene prediction method: GeneMarkS+. | Translocation-enhancing protein TepA; Derived by automated computational analysis using gene prediction method: GeneMarkS+. | 0.597 |
AGX06697.1 | clpP | N288_24310 | N288_21640 | Actin; Derived by automated computational analysis using gene prediction method: GeneMarkS+. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.597 |