OAH45468.1 protein (Sphingobium yanoikuyae) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

OAH45468.1

Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)

Predicted Functional Partners:

OAH45387.1

0.492

OAH42667.1

0.447

OAH35346.1

0.445

OAH45281.1

0.442

OAH45384.1

0.440

OAH45386.1

0.434

OAH45385.1

0.429

OAH46004.1

0.427

OAH45751.1

0.408

Your Current Organism:

Sphingobium yanoikuyae

NCBI taxonomy Id: 13690
Other names: ATCC 51230, Beijerinckia sp. B1, CCUG 28380, CCUG 31205, CIP 106726, DSM 7462, GIFU 9882, GIFU:9882, IFO 15102, JCM 7371, LMG 11252, LMG:11252, NBRC 15102, S. yanoikuyae, Sphingobium sp. TJ, Sphingomonas yanoikuyae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OAH35346.1	OAH42667.1	AX777_02685	AX777_05305	Siroheme synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.530
OAH35346.1	OAH45281.1	AX777_02685	AX777_07175	Siroheme synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.468
OAH35346.1	OAH45468.1	AX777_02685	AX777_17415	Siroheme synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.445
OAH35346.1	OAH45751.1	AX777_02685	AX777_03685	Siroheme synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	NADH-quinone oxidoreductase subunit L; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.447
OAH35346.1	OAH46004.1	AX777_02685	AX777_09495	Siroheme synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glutamate synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.438
OAH42667.1	OAH35346.1	AX777_05305	AX777_02685	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Siroheme synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.530
OAH42667.1	OAH45281.1	AX777_05305	AX777_07175	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.990
OAH42667.1	OAH45468.1	AX777_05305	AX777_17415	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.447
OAH42667.1	OAH46004.1	AX777_05305	AX777_09495	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glutamate synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.718
OAH45281.1	OAH35346.1	AX777_07175	AX777_02685	Histidine phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Siroheme synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.468
OAH45281.1	OAH42667.1	AX777_07175	AX777_05305	Histidine phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.990
OAH45281.1	OAH45468.1	AX777_07175	AX777_17415	Histidine phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.442
OAH45281.1	OAH46004.1	AX777_07175	AX777_09495	Histidine phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glutamate synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.713
OAH45384.1	OAH45385.1	AX777_17395	AX777_17400	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.987
OAH45384.1	OAH45386.1	AX777_17395	AX777_17405	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.966
OAH45384.1	OAH45387.1	AX777_17395	AX777_17410	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.661
OAH45384.1	OAH45468.1	AX777_17395	AX777_17415	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.440
OAH45385.1	OAH45384.1	AX777_17400	AX777_17395	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.987
OAH45385.1	OAH45386.1	AX777_17400	AX777_17405	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.972
OAH45385.1	OAH45387.1	AX777_17400	AX777_17410	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.661

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Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.46

expected number of edges:

10

PPI enrichment p-value:

1.13e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006396

RNA processing

6 of 91

1.7

2.37

1.24e-06

GO:0034470

ncRNA processing

5 of 75

1.7

2.06

1.40e-05

GO:0008033

tRNA processing

4 of 56

1.73

1.71

0.00017

GO:0009451

RNA modification

4 of 58

1.72

1.7

0.00017

GO:0006364

rRNA processing

3 of 21

2.03

1.67

0.00050

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

5 of 134

1.45

1.36

0.00040

GO:0140098

Catalytic activity, acting on RNA

5 of 154

1.39

1.3

0.00040

GO:0008649

rRNA methyltransferase activity

2 of 6

2.4

1.18

0.0068

GO:0051539

4 iron, 4 sulfur cluster binding

3 of 43

1.72

1.13

0.0049

GO:0000049

tRNA binding

2 of 25

1.78

0.8

0.0282

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 1478

0.71

0.64

5.18e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2315

Mixed, incl. tRNA processing, and NusB family

4 of 21

2.16

2.28

3.19e-05

CL:2316

Mixed, incl. NusB family, and Methylthiotransferase

3 of 12

2.28

1.73

0.00053

CL:1849

Translation, and Ribosome biogenesis

5 of 142

1.42

1.3

0.00053

CL:2073

Mixed, incl. TGS-like, and RF-1 domain

2 of 6

2.4

1.02

0.0137

CL:2110

3-5 exonuclease, and S1 domain

2 of 8

2.28

0.94

0.0183

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005829

Cytosol

5 of 399

0.98

0.59

0.0210

GOCC:0005737

Cytoplasm

7 of 1152

0.66

0.43

0.0210

GOCC:0005622

Intracellular

9 of 1930

0.55

0.37

0.0210

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0698

rRNA processing

3 of 13

2.24

2.15

7.19e-05

KW-0949

S-adenosyl-L-methionine

4 of 52

1.76

1.89

6.65e-05

KW-0963

Cytoplasm

7 of 238

1.35

1.76

1.20e-06

KW-0819

tRNA processing

3 of 28

1.91

1.65

0.00043

KW-0004

4Fe-4S

3 of 39

1.76

1.46

0.00087

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR007197

Radical SAM

3 of 24

1.97

1.06

0.0094

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00729

Elongator protein 3, MiaB family, Radical SAM

3 of 18

2.1

1.78

0.00034

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