chiPu_0022494 protein (Chiloscyllium punctatum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

chiPu_0022494

Uncharacterized protein. (254 aa)

Predicted Functional Partners:

chiPu_0021919

0.595

chiPu_0020439

0.595

chiPu_0020438

0.595

chiPu_0017602

0.595

chiPu_0018400

0.595

chiPu_0003335

0.595

chiPu_0007596

0.595

chiPu_0023165

0.595

chiPu_0023490

0.595

chiPu_0027344

0.595

Your Current Organism:

Chiloscyllium punctatum

NCBI taxonomy Id: 137246
Other names: C. punctatum, brownbanded bambooshark

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
chiPu_0003335	chiPu_0022494	A0A401S3I7	A0A401RHP0	Uncharacterized protein.	Uncharacterized protein.	0.595
chiPu_0003335	chiPu_0023165	A0A401S3I7	A0A401T8B5	Uncharacterized protein.	Uncharacterized protein.	0.683
chiPu_0003335	chiPu_0023490	A0A401S3I7	A0A401TB63	Uncharacterized protein.	Fibronectin type-III domain-containing protein.	0.706
chiPu_0003335	chiPu_0027344	A0A401S3I7	A0A401TL76	Uncharacterized protein.	Uncharacterized protein.	0.675
chiPu_0007596	chiPu_0022494	A0A401SFH7	A0A401RHP0	Uncharacterized protein.	Uncharacterized protein.	0.595
chiPu_0017602	chiPu_0022494	A0A401RHF1	A0A401RHP0	Uncharacterized protein.	Uncharacterized protein.	0.595
chiPu_0018400	chiPu_0020439	A0A401RMZ0	A0A401RFM7	Uncharacterized protein.	Uncharacterized protein.	0.845
chiPu_0018400	chiPu_0021919	A0A401RMZ0	A0A401RF61	Uncharacterized protein.	Uncharacterized protein.	0.682
chiPu_0018400	chiPu_0022494	A0A401RMZ0	A0A401RHP0	Uncharacterized protein.	Uncharacterized protein.	0.595
chiPu_0020438	chiPu_0020439	A0A401RFM8	A0A401RFM7	Uncharacterized protein.	Uncharacterized protein.	0.950
chiPu_0020438	chiPu_0022494	A0A401RFM8	A0A401RHP0	Uncharacterized protein.	Uncharacterized protein.	0.595
chiPu_0020438	chiPu_0023490	A0A401RFM8	A0A401TB63	Uncharacterized protein.	Fibronectin type-III domain-containing protein.	0.777
chiPu_0020439	chiPu_0018400	A0A401RFM7	A0A401RMZ0	Uncharacterized protein.	Uncharacterized protein.	0.845
chiPu_0020439	chiPu_0020438	A0A401RFM7	A0A401RFM8	Uncharacterized protein.	Uncharacterized protein.	0.950
chiPu_0020439	chiPu_0021919	A0A401RFM7	A0A401RF61	Uncharacterized protein.	Uncharacterized protein.	0.760
chiPu_0020439	chiPu_0022494	A0A401RFM7	A0A401RHP0	Uncharacterized protein.	Uncharacterized protein.	0.595
chiPu_0021919	chiPu_0018400	A0A401RF61	A0A401RMZ0	Uncharacterized protein.	Uncharacterized protein.	0.682
chiPu_0021919	chiPu_0020439	A0A401RF61	A0A401RFM7	Uncharacterized protein.	Uncharacterized protein.	0.760
chiPu_0021919	chiPu_0022494	A0A401RF61	A0A401RHP0	Uncharacterized protein.	Uncharacterized protein.	0.595
chiPu_0022494	chiPu_0003335	A0A401RHP0	A0A401S3I7	Uncharacterized protein.	Uncharacterized protein.	0.595

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.861

expected number of edges:

15

PPI enrichment p-value:

9.74e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015295

Solute:proton symporter activity

2 of 17

2.34

0.73

0.0466

GO:0015293

Symporter activity

3 of 135

1.62

0.67

0.0466

GO:0022857

Transmembrane transporter activity

6 of 1092

1.01

0.59

0.0262

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:28817687

(2017) Morphologic, phenotypic, and transcriptomic characterization of classically and alternatively activated canine blood-derived macrophages in vitro.

4 of 57

2.12

1.06

0.0102

PMID:19720156

(2009) Drug transporter, P-glycoprotein (MDR1), is an integrated component of the mammalian blood-testis barrier.

3 of 14

2.6

0.97

0.0172

PMID:34552089

(2021) Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases.

3 of 21

2.43

0.8

0.0342

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13710

Connexin, and FAM193 family

4 of 24

2.49

2.86

3.90e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-425407

SLC-mediated transmembrane transport

4 of 305

1.39

0.73

0.0256

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036259

MFS transporter superfamily

4 of 120

1.8

1.26

0.0027

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