chiPu_0017647 protein (Chiloscyllium punctatum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

chiPu_0017647

Uncharacterized protein. (780 aa)

Predicted Functional Partners:

chiPu_0017023

0.961

chiPu_0006894

0.856

chiPu_0015908

0.829

chiPu_0001911

0.804

chiPu_0004558

0.804

chiPu_0011607

0.732

chiPu_0024780

0.732

chiPu_0017566

0.724

chiPu_0018069

0.703

CXCL8-8

0.698

Your Current Organism:

Chiloscyllium punctatum

NCBI taxonomy Id: 137246
Other names: C. punctatum, brownbanded bambooshark

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CXCL8-8	chiPu_0017647	A0A401T8C9	A0A401RHV7	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family.	Uncharacterized protein.	0.698
chiPu_0001911	chiPu_0004558	A0A401RZD6	A0A401S6X5	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.890
chiPu_0001911	chiPu_0006894	A0A401RZD6	A0A401SDN1	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Ig-like domain-containing protein.	0.717
chiPu_0001911	chiPu_0017647	A0A401RZD6	A0A401RHV7	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Uncharacterized protein.	0.804
chiPu_0001911	chiPu_0018069	A0A401RZD6	A0A401RKW6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.778
chiPu_0004558	chiPu_0001911	A0A401S6X5	A0A401RZD6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.890
chiPu_0004558	chiPu_0006894	A0A401S6X5	A0A401SDN1	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Ig-like domain-containing protein.	0.717
chiPu_0004558	chiPu_0017647	A0A401S6X5	A0A401RHV7	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Uncharacterized protein.	0.804
chiPu_0004558	chiPu_0018069	A0A401S6X5	A0A401RKW6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.778
chiPu_0006894	chiPu_0001911	A0A401SDN1	A0A401RZD6	Ig-like domain-containing protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.717
chiPu_0006894	chiPu_0004558	A0A401SDN1	A0A401S6X5	Ig-like domain-containing protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.717
chiPu_0006894	chiPu_0017566	A0A401SDN1	A0A401RH31	Ig-like domain-containing protein.	Uncharacterized protein.	0.411
chiPu_0006894	chiPu_0017647	A0A401SDN1	A0A401RHV7	Ig-like domain-containing protein.	Uncharacterized protein.	0.856
chiPu_0006894	chiPu_0018069	A0A401SDN1	A0A401RKW6	Ig-like domain-containing protein.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.555
chiPu_0011607	chiPu_0017647	A0A401SRW5	A0A401RHV7	Microtubule-associated protein.	Uncharacterized protein.	0.732
chiPu_0011607	chiPu_0018069	A0A401SRW5	A0A401RKW6	Microtubule-associated protein.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.728
chiPu_0015908	chiPu_0017647	A0A401T466	A0A401RHV7	C1q domain-containing protein.	Uncharacterized protein.	0.829
chiPu_0015908	chiPu_0018069	A0A401T466	A0A401RKW6	C1q domain-containing protein.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.513
chiPu_0017023	chiPu_0017647	A0A401T790	A0A401RHV7	Ig-like domain-containing protein.	Uncharacterized protein.	0.961
chiPu_0017566	chiPu_0006894	A0A401RH31	A0A401SDN1	Uncharacterized protein.	Ig-like domain-containing protein.	0.411

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.866

expected number of edges:

12

PPI enrichment p-value:

4.14e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044272

Sulfur compound biosynthetic process

10 of 25

1.76

4.24

5.16e-14

GO:0006085

acetyl-CoA biosynthetic process

3 of 4

2.04

1.55

0.00094

GO:0006082

Organic acid metabolic process

10 of 155

0.97

1.11

2.70e-07

GO:0006086

acetyl-CoA biosynthetic process from pyruvate

2 of 3

1.99

0.95

0.0153

GO:1901576

Organic substance biosynthetic process

10 of 378

0.58

0.48

0.00075

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016903

Oxidoreductase activity, acting on the aldehyde or oxo group of donors

4 of 14

1.62

1.41

0.00068

GO:0030976

Thiamine pyrophosphate binding

3 of 5

1.94

1.4

0.0017

GO:0016625

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

3 of 6

1.86

1.37

0.0017

GO:0016491

Oxidoreductase activity

8 of 115

1.0

5.02e-05

GO:0003824

Catalytic activity

11 of 692

0.36

0.3

0.0060

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:969

Butanoate metabolism

6 of 6

2.16

4.2

8.38e-10

CL:964

Citrate cycle (TCA cycle), and Cysteine-rich domain

9 of 20

1.82

4.19

9.45e-13

CL:965

Glycolysis / Gluconeogenesis

7 of 12

1.93

3.96

1.69e-10

CL:961

Mixed, incl. Glycolysis / Gluconeogenesis, and Citrate cycle (TCA cycle)

10 of 51

1.45

2.75

4.41e-12

CL:989

Indolepyruvate ferredoxin oxidoreductase activity, and FAD binding domain

2 of 5

1.76

0.84

0.0229

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00650

Butanoate metabolism

8 of 13

1.95

4.66

8.95e-13

map00010

Glycolysis / Gluconeogenesis

9 of 19

1.84

4.49

8.54e-14

map00720

Carbon fixation pathways in prokaryotes

10 of 30

1.68

3.95

2.63e-14

map00020

Citrate cycle (TCA cycle)

8 of 19

1.79

3.91

5.80e-12

map00640

Propanoate metabolism

7 of 17

1.78

3.51

2.57e-10

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005618

Cell wall

2 of 2

2.16

0.74

0.0433

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0560

Oxidoreductase

4 of 34

1.23

0.81

0.0098

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01855

Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg

5 of 5

2.16

3.17

3.01e-07

PF02775

Thiamine pyrophosphate enzyme, C-terminal TPP binding domain

4 of 6

1.99

2.2

2.86e-05

PF17147

Pyruvate:ferredoxin oxidoreductase core domain II

3 of 3

2.16

1.78

0.00037

PF01558

Pyruvate ferredoxin/flavodoxin oxidoreductase

3 of 4

2.04

1.68

0.00048

PF00037

4Fe-4S binding domain

3 of 9

1.68

1.24

0.0024

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029061

Thiamin diphosphate-binding fold

4 of 6

1.99

1.95

0.00011

IPR011766

Thiamine pyrophosphate enzyme, TPP-binding

4 of 6

1.99

1.95

0.00011

IPR017900

4Fe-4S ferredoxin, iron-sulphur binding, conserved site

4 of 15

1.59

1.41

0.00063

IPR017896

4Fe-4S ferredoxin-type, iron-sulphur binding domain

4 of 19

1.49

1.25

0.0011

IPR009014

Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II

2 of 2

2.16

0.89

0.0219

(more ...)

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