chiPu_0017790 protein (Chiloscyllium punctatum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

chiPu_0017790

FeS_assembly_P domain-containing protein. (161 aa)

Predicted Functional Partners:

CIAO1

0.986

chiPu_0011507

0.985

chiPu_0014344

0.918

chiPu_0013987

0.906

chiPu_0015201

0.906

chiPu_0017381

0.794

chiPu_0001026

0.794

chiPu_0008671

0.794

chiPu_0016861

0.754

chiPu_0031999

0.750

Your Current Organism:

Chiloscyllium punctatum

NCBI taxonomy Id: 137246
Other names: C. punctatum, brownbanded bambooshark

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CIAO1	chiPu_0001026	A0A401RY85	A0A401RX08	Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Belongs to the WD repeat CIA1 family.	Helicase ATP-binding domain-containing protein.	0.816
CIAO1	chiPu_0008671	A0A401RY85	A0A401SIQ0	Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Belongs to the WD repeat CIA1 family.	Helicase ATP-binding domain-containing protein.	0.816
CIAO1	chiPu_0011507	A0A401RY85	A0A401SRL4	Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Belongs to the WD repeat CIA1 family.	Uncharacterized protein.	0.993
CIAO1	chiPu_0013987	A0A401RY85	A0A401SYM2	Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Belongs to the WD repeat CIA1 family.	Fe_hyd_SSU domain-containing protein; Belongs to the NARF family.	0.931
CIAO1	chiPu_0014344	A0A401RY85	A0A401SZP1	Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Belongs to the WD repeat CIA1 family.	Helicase ATP-binding domain-containing protein.	0.938
CIAO1	chiPu_0015201	A0A401RY85	A0A401T222	Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Belongs to the WD repeat CIA1 family.	Fe_hyd_SSU domain-containing protein; Belongs to the NARF family.	0.931
CIAO1	chiPu_0016861	A0A401RY85	A0A401T6W0	Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Belongs to the WD repeat CIA1 family.	Uncharacterized protein.	0.740
CIAO1	chiPu_0017381	A0A401RY85	A0A401RFG4	Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Belongs to the WD repeat CIA1 family.	Helicase ATP-binding domain-containing protein.	0.816
CIAO1	chiPu_0017790	A0A401RY85	A0A401RIU8	Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Belongs to the WD repeat CIA1 family.	FeS_assembly_P domain-containing protein.	0.986
CIAO1	chiPu_0031999	A0A401RY85	A0A401TZA9	Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Belongs to the WD repeat CIA1 family.	Uncharacterized protein.	0.558
chiPu_0001026	CIAO1	A0A401RX08	A0A401RY85	Helicase ATP-binding domain-containing protein.	Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Belongs to the WD repeat CIA1 family.	0.816
chiPu_0001026	chiPu_0011507	A0A401RX08	A0A401SRL4	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.934
chiPu_0001026	chiPu_0013987	A0A401RX08	A0A401SYM2	Helicase ATP-binding domain-containing protein.	Fe_hyd_SSU domain-containing protein; Belongs to the NARF family.	0.511
chiPu_0001026	chiPu_0015201	A0A401RX08	A0A401T222	Helicase ATP-binding domain-containing protein.	Fe_hyd_SSU domain-containing protein; Belongs to the NARF family.	0.511
chiPu_0001026	chiPu_0016861	A0A401RX08	A0A401T6W0	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.825
chiPu_0001026	chiPu_0017790	A0A401RX08	A0A401RIU8	Helicase ATP-binding domain-containing protein.	FeS_assembly_P domain-containing protein.	0.794
chiPu_0008671	CIAO1	A0A401SIQ0	A0A401RY85	Helicase ATP-binding domain-containing protein.	Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Belongs to the WD repeat CIA1 family.	0.816
chiPu_0008671	chiPu_0011507	A0A401SIQ0	A0A401SRL4	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.934
chiPu_0008671	chiPu_0013987	A0A401SIQ0	A0A401SYM2	Helicase ATP-binding domain-containing protein.	Fe_hyd_SSU domain-containing protein; Belongs to the NARF family.	0.511
chiPu_0008671	chiPu_0015201	A0A401SIQ0	A0A401T222	Helicase ATP-binding domain-containing protein.	Fe_hyd_SSU domain-containing protein; Belongs to the NARF family.	0.511

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

49

average node degree:

8.91

avg. local clustering coefficient:

0.952

expected number of edges:

18

PPI enrichment p-value:

2.14e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046081

dUTP catabolic process

2 of 2

3.09

1.06

0.0122

GO:0006226

dUMP biosynthetic process

2 of 3

2.91

1.06

0.0122

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004170

dUTP diphosphatase activity

2 of 2

3.09

1.26

0.0053

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14146

Deoxyribonucleotide biosynthetic process, and Dihydrofolate metabolic process

3 of 12

2.48

1.86

0.00035

CL:10229

Nucleosomal DNA binding, and Replication factor A protein-like

2 of 6

2.61

1.15

0.0081

CL:14149

2-deoxyribonucleotide biosynthetic process, and Dihydrofolate metabolic process

2 of 7

2.54

1.14

0.0083

CL:12033

Activator

2 of 7

2.54

1.14

0.0083

CL:11179

Reverse transcriptase, RNA-dependent DNA polymerase, and GAG-pre-integrase domain

2 of 13

2.27

0.96

0.0172

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00240

Pyrimidine metabolism

3 of 66

1.74

1.51

0.00060

map03430

Mismatch repair

4 of 142

1.54

1.38

0.00060

map03420

Nucleotide excision repair

4 of 150

1.51

1.36

0.00060

map03030

DNA replication

4 of 158

1.49

1.34

0.00060

map03440

Homologous recombination

4 of 190

1.41

1.27

0.00060

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0010

Activator

2 of 12

2.31

1.03

0.0126

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR040260

Replication factor A protein-like

3 of 3

3.09

2.56

2.30e-05

IPR012340

Nucleic acid-binding, OB-fold

3 of 56

1.82

0.89

0.0183

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (22%) [HD]

Permalink

Credits

Access

Info

About

STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About