STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
chiPu_0000318Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (174 aa)    
Predicted Functional Partners:
chiPu_0000653
Fibroblast growth factor receptor.
    
 0.966
chiPu_0001432
Uncharacterized protein.
    
 0.966
chiPu_0001431
Ig-like domain-containing protein.
    
 0.966
chiPu_0011897
Fibroblast growth factor receptor.
    
 0.966
chiPu_0016749
Fibroblast growth factor receptor.
    
 0.966
chiPu_0014953
Uncharacterized protein.
    
 0.904
chiPu_0019438
Uncharacterized protein.
    
 0.888
chiPu_0014540
Uncharacterized protein.
    
 0.888
chiPu_0001757
Uncharacterized protein.
    
 0.883
chiPu_0013383
Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.
    
 0.883
Your Current Organism:
Chiloscyllium punctatum
NCBI taxonomy Id: 137246
Other names: C. punctatum, brownbanded bambooshark
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.