chiPu_0002053 protein (Chiloscyllium punctatum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

chiPu_0002053

Uncharacterized protein. (941 aa)

Predicted Functional Partners:

chiPu_0007634

0.816

chiPu_0016255

0.770

chiPu_0002227

0.769

chiPu_0011357

0.756

chiPu_0012386

0.629

chiPu_0011397

0.523

chiPu_0002929

0.515

chiPu_0016569

0.492

chiPu_0017182

0.489

chiPu_0006699

0.476

Your Current Organism:

Chiloscyllium punctatum

NCBI taxonomy Id: 137246
Other names: C. punctatum, brownbanded bambooshark

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
chiPu_0002053	chiPu_0002227	A0A401RZS7	A0A401S0B8	Uncharacterized protein.	PCM1_C domain-containing protein.	0.769
chiPu_0002053	chiPu_0002929	A0A401RZS7	A0A401S2D3	Uncharacterized protein.	Uncharacterized protein.	0.515
chiPu_0002053	chiPu_0006699	A0A401RZS7	A0A401SD45	Uncharacterized protein.	Uncharacterized protein.	0.476
chiPu_0002053	chiPu_0007634	A0A401RZS7	A0A401SFL5	Uncharacterized protein.	Uncharacterized protein.	0.816
chiPu_0002053	chiPu_0011357	A0A401RZS7	A0A401SRB5	Uncharacterized protein.	LisH domain-containing protein.	0.756
chiPu_0002053	chiPu_0011397	A0A401RZS7	A0A401SRF6	Uncharacterized protein.	2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.	0.523
chiPu_0002053	chiPu_0012386	A0A401RZS7	A0A401SU39	Uncharacterized protein.	CEP63 domain-containing protein.	0.629
chiPu_0002053	chiPu_0016255	A0A401RZS7	A0A401T539	Uncharacterized protein.	LisH domain-containing protein.	0.770
chiPu_0002053	chiPu_0016569	A0A401RZS7	A0A401T5Y1	Uncharacterized protein.	Uncharacterized protein.	0.492
chiPu_0002053	chiPu_0017182	A0A401RZS7	A0A401T7T8	Uncharacterized protein.	Uncharacterized protein.	0.489
chiPu_0002227	chiPu_0002053	A0A401S0B8	A0A401RZS7	PCM1_C domain-containing protein.	Uncharacterized protein.	0.769
chiPu_0002227	chiPu_0006699	A0A401S0B8	A0A401SD45	PCM1_C domain-containing protein.	Uncharacterized protein.	0.742
chiPu_0002227	chiPu_0007634	A0A401S0B8	A0A401SFL5	PCM1_C domain-containing protein.	Uncharacterized protein.	0.740
chiPu_0002227	chiPu_0011357	A0A401S0B8	A0A401SRB5	PCM1_C domain-containing protein.	LisH domain-containing protein.	0.868
chiPu_0002227	chiPu_0016255	A0A401S0B8	A0A401T539	PCM1_C domain-containing protein.	LisH domain-containing protein.	0.744
chiPu_0002227	chiPu_0016569	A0A401S0B8	A0A401T5Y1	PCM1_C domain-containing protein.	Uncharacterized protein.	0.469
chiPu_0002929	chiPu_0002053	A0A401S2D3	A0A401RZS7	Uncharacterized protein.	Uncharacterized protein.	0.515
chiPu_0002929	chiPu_0007634	A0A401S2D3	A0A401SFL5	Uncharacterized protein.	Uncharacterized protein.	0.495
chiPu_0002929	chiPu_0011357	A0A401S2D3	A0A401SRB5	Uncharacterized protein.	LisH domain-containing protein.	0.476
chiPu_0002929	chiPu_0012386	A0A401S2D3	A0A401SU39	Uncharacterized protein.	CEP63 domain-containing protein.	0.512

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.836

expected number of edges:

11

PPI enrichment p-value:

0.0161

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006629

Lipid metabolic process

8 of 1176

1.32

1.65

2.82e-06

GO:0044255

Cellular lipid metabolic process

6 of 880

1.32

1.22

0.00044

GO:0006490

Oligosaccharide-lipid intermediate biosynthetic process

2 of 14

2.64

1.03

0.0132

GO:0034645

Cellular macromolecule biosynthetic process

5 of 834

1.26

0.9

0.0052

GO:0044242

Cellular lipid catabolic process

3 of 198

1.66

0.79

0.0268

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016758

Hexosyltransferase activity

6 of 233

1.89

2.96

1.50e-07

GO:0004376

Glycolipid mannosyltransferase activity

2 of 7

2.94

1.38

0.0032

GO:0004373

Glycogen (starch) synthase activity

2 of 7

2.94

1.38

0.0032

GO:0008194

UDP-glycosyltransferase activity

3 of 180

1.71

0.99

0.0099

GO:0016790

Thiolester hydrolase activity

2 of 49

2.09

0.81

0.0304

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005782

Peroxisomal matrix

2 of 20

2.48

0.91

0.0223

GO:0005737

Cytoplasm

11 of 12389

0.43

0.31

0.0223

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:28161

Thiolase, C-terminal domain, and delta(3)-delta(2)-enoyl-CoA isomerase activity

3 of 6

3.18

2.74

1.09e-05

CL:33443

N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity, and Glycosyl transferase, family 1

2 of 5

3.09

1.7

0.00085

CL:33352

GPI anchor metabolic process, and Oligosaccharide-lipid intermediate biosynthetic process

3 of 58

2.2

1.69

0.00058

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01040

Biosynthesis of unsaturated fatty acids

4 of 62

2.29

3.2

4.55e-07

map04146

Peroxisome

4 of 178

1.84

2.16

1.83e-05

map00120

Primary bile acid biosynthesis

2 of 14

2.64

1.81

0.00048

map01212

Fatty acid metabolism

3 of 124

1.87

1.63

0.00044

map00513

Various types of N-glycan biosynthesis

2 of 59

2.01

1.16

0.0060

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2046106

Alpha-linolenic acid (ALA) metabolism

4 of 21

2.76

3.7

1.27e-07

MAP-2046104

Alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

4 of 21

2.76

3.7

1.27e-07

MAP-193368

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

4 of 23

2.72

3.69

1.27e-07

MAP-389887

Beta-oxidation of pristanoyl-CoA

4 of 25

2.69

3.68

1.27e-07

MAP-192105

Synthesis of bile acids and bile salts

4 of 35

2.54

3.56

1.65e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005777

Peroxisome

4 of 128

1.98

1.93

0.00012

GOCC:0005782

Peroxisomal matrix

2 of 21

2.46

1.03

0.0128

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0320

Glycogen biosynthesis

2 of 5

3.09

1.77

0.00064

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13692

Glycosyl transferases group 1

3 of 5

3.26

3.01

3.61e-06

PF02803

Thiolase, C-terminal domain

3 of 10

2.96

2.76

9.22e-06

PF05693

Glycogen synthase

2 of 5

3.09

1.53

0.0017

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001296

Glycosyl transferase, family 1

3 of 8

3.06

2.48

3.12e-05

IPR016039

Thiolase-like

3 of 22

2.62

1.98

0.00022

IPR008631

Glycogen synthase

2 of 5

3.09

1.28

0.0049

IPR020617

Thiolase, C-terminal

2 of 9

2.83

1.11

0.0097

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