chiPu_0002676 protein (Chiloscyllium punctatum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

chiPu_0002676

Uncharacterized protein. (242 aa)

Predicted Functional Partners:

chiPu_0004027

0.998

chiPu_0014968

0.976

chiPu_0007053

0.956

chiPu_0008585

0.956

chiPu_0019155

0.953

chiPu_0002546

0.932

chiPu_0012941

0.932

chiPu_0000263

0.929

chiPu_0008819

0.929

chiPu_0012374

0.929

Your Current Organism:

Chiloscyllium punctatum

NCBI taxonomy Id: 137246
Other names: C. punctatum, brownbanded bambooshark

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
chiPu_0000263	chiPu_0002676	A0A401RUT6	A0A401S1M2	Uncharacterized protein.	Uncharacterized protein.	0.929
chiPu_0000263	chiPu_0004027	A0A401RUT6	A0A401S5E8	Uncharacterized protein.	Uncharacterized protein.	0.716
chiPu_0000263	chiPu_0008819	A0A401RUT6	A0A401SIZ9	Uncharacterized protein.	Rho-GAP domain-containing protein.	0.576
chiPu_0000263	chiPu_0014968	A0A401RUT6	A0A401T1H4	Uncharacterized protein.	Uncharacterized protein.	0.497
chiPu_0000263	chiPu_0019155	A0A401RUT6	A0A401RR10	Uncharacterized protein.	Uncharacterized protein.	0.552
chiPu_0002546	chiPu_0002676	A0A401S190	A0A401S1M2	Uncharacterized protein.	Uncharacterized protein.	0.932
chiPu_0002546	chiPu_0007053	A0A401S190	A0A401SDX8	Uncharacterized protein.	Uncharacterized protein.	0.599
chiPu_0002546	chiPu_0008585	A0A401S190	A0A401SIB4	Uncharacterized protein.	Sema domain-containing protein.	0.599
chiPu_0002546	chiPu_0012941	A0A401S190	A0A401SVN8	Uncharacterized protein.	Uncharacterized protein.	0.891
chiPu_0002546	chiPu_0019155	A0A401S190	A0A401RR10	Uncharacterized protein.	Uncharacterized protein.	0.455
chiPu_0002676	chiPu_0000263	A0A401S1M2	A0A401RUT6	Uncharacterized protein.	Uncharacterized protein.	0.929
chiPu_0002676	chiPu_0002546	A0A401S1M2	A0A401S190	Uncharacterized protein.	Uncharacterized protein.	0.932
chiPu_0002676	chiPu_0004027	A0A401S1M2	A0A401S5E8	Uncharacterized protein.	Uncharacterized protein.	0.998
chiPu_0002676	chiPu_0007053	A0A401S1M2	A0A401SDX8	Uncharacterized protein.	Uncharacterized protein.	0.956
chiPu_0002676	chiPu_0008585	A0A401S1M2	A0A401SIB4	Uncharacterized protein.	Sema domain-containing protein.	0.956
chiPu_0002676	chiPu_0008819	A0A401S1M2	A0A401SIZ9	Uncharacterized protein.	Rho-GAP domain-containing protein.	0.929
chiPu_0002676	chiPu_0012374	A0A401S1M2	A0A401SU64	Uncharacterized protein.	Uncharacterized protein.	0.929
chiPu_0002676	chiPu_0012941	A0A401S1M2	A0A401SVN8	Uncharacterized protein.	Uncharacterized protein.	0.932
chiPu_0002676	chiPu_0014968	A0A401S1M2	A0A401T1H4	Uncharacterized protein.	Uncharacterized protein.	0.976
chiPu_0002676	chiPu_0019155	A0A401S1M2	A0A401RR10	Uncharacterized protein.	Uncharacterized protein.	0.953

page 1 of 4

Network Stats

number of nodes:

5

number of edges:

4

average node degree:

1.6

avg. local clustering coefficient:

0.8

expected number of edges:

4

PPI enrichment p-value:

0.569

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006487

Protein N-linked glycosylation

7 of 22

2.28

5.16

1.01e-11

GO:0006486

Protein glycosylation

8 of 63

1.88

4.09

2.05e-11

GO:0006616

SRP-dependent cotranslational protein targeting to membrane, translocation

2 of 2

2.78

1.5

0.0019

GO:0031204

Post-translational protein targeting to membrane, translocation

2 of 3

2.6

1.4

0.0027

GO:0018279

Protein N-linked glycosylation via asparagine

2 of 3

2.6

1.4

0.0027

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008250

Oligosaccharyltransferase complex

6 of 6

2.78

6.51

3.46e-13

GO:0140534

Endoplasmic reticulum protein-containing complex

8 of 29

2.22

5.99

2.32e-14

GO:0005789

Endoplasmic reticulum membrane

10 of 132

1.66

3.82

3.09e-14

GO:0005783

Endoplasmic reticulum

11 of 208

1.5

3.16

2.32e-14

GO:0098796

Membrane protein complex

8 of 171

1.45

2.4

2.39e-09

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6398

Oligosaccharyltransferase complex, and Translocon complex

9 of 11

2.69

9.56

4.65e-20

CL:6362

N-Glycan biosynthesis, and Translocon complex

11 of 32

2.31

8.99

2.20e-22

CL:6401

Oligosaccharyltransferase complex

5 of 5

2.78

5.16

1.84e-10

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

gsl00510

N-Glycan biosynthesis

8 of 27

2.25

6.32

4.85e-15

gsl04141

Protein processing in endoplasmic reticulum

8 of 68

1.85

4.24

1.91e-12

gsl00513

Various types of N-glycan biosynthesis

5 of 17

2.25

4.04

4.34e-09

gsl03060

Protein export

2 of 25

1.68

0.85

0.0197

gsl04145

Phagosome

2 of 29

1.62

0.82

0.0216

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5663205

Infectious disease

5 of 27

2.05

2.92

6.51e-07

MAP-1643685

Disease

5 of 34

1.95

2.75

9.26e-07

MAP-446203

Asparagine N-linked glycosylation

6 of 120

1.48

1.88

4.55e-06

MAP-597592

Post-translational protein modification

6 of 400

0.95

0.73

0.0034

MAP-1799339

SRP-dependent cotranslational protein targeting to membrane

3 of 84

1.33

0.63

0.0421

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0008250

Oligosaccharyltransferase complex

6 of 7

2.71

6.15

1.42e-12

GOCC:0005789

Endoplasmic reticulum membrane

9 of 54

2.0

5.33

1.21e-14

GOCC:0005783

Endoplasmic reticulum

8 of 111

1.64

3.11

2.14e-10

GOCC:0098796

Membrane protein complex

8 of 154

1.49

2.53

2.11e-09

GOCC:0005784

Sec61 translocon complex

2 of 2

2.78

1.69

0.00082

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0256

Endoplasmic reticulum

4 of 31

1.89

2.05

4.52e-05

KW-1133

Transmembrane helix

10 of 1231

0.69

0.62

5.14e-05

KW-0808

Transferase

6 of 748

0.68

0.43

0.0257

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