STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
chiPu_0004870RING-type domain-containing protein. (736 aa)    
Predicted Functional Partners:
chiPu_0017789
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
   
 
 0.969
chiPu_0005383
Uncharacterized protein.
    
   0.961
chiPu_0001397
Uncharacterized protein.
    
 
 0.943
chiPu_0024671
Uncharacterized protein.
    
 
 0.943
chiPu_0013990
Uncharacterized protein.
   
 
 0.899
chiPu_0020557
Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
    
 
 0.809
chiPu_0019076
Uncharacterized protein.
    
 
 0.809
chiPu_0028604
RPA_C domain-containing protein.
    
 
 0.809
chiPu_0008564
Uncharacterized protein.
    
 
 0.790
chiPu_0009481
CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
    
 
 0.755
Your Current Organism:
Chiloscyllium punctatum
NCBI taxonomy Id: 137246
Other names: C. punctatum, brownbanded bambooshark
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.