chiPu_0006922 protein (Chiloscyllium punctatum)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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[Homology]

Score

chiPu_0006922

Uncharacterized protein. (554 aa)

Predicted Functional Partners:

chiPu_0031691

0.906

chiPu_0021265

0.902

chiPu_0030367

0.902

chiPu_0020713

0.867

chiPu_0019785

0.867

chiPu_0004127

0.867

chiPu_0026480

0.867

COQ2

0.848

chiPu_0000939

0.844

chiPu_0004278

0.844

Your Current Organism:

Chiloscyllium punctatum

NCBI taxonomy Id: 137246
Other names: C. punctatum, brownbanded bambooshark

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COQ2	chiPu_0000939	A0A401SH48	A0A401RWP3	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.480
COQ2	chiPu_0004127	A0A401SH48	A0A401S5Q2	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Uncharacterized protein.	0.761
COQ2	chiPu_0004278	A0A401SH48	A0A401S643	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.480
COQ2	chiPu_0006922	A0A401SH48	A0A401SDJ5	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Uncharacterized protein.	0.848
COQ2	chiPu_0019785	A0A401SH48	A0A401RT59	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	WD_REPEATS_REGION domain-containing protein.	0.761
COQ2	chiPu_0020713	A0A401SH48	A0A401RIR0	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Uncharacterized protein.	0.761
COQ2	chiPu_0021265	A0A401SH48	A0A401RPI8	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Uncharacterized protein.	0.768
COQ2	chiPu_0026480	A0A401SH48	A0A401TJ74	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Uncharacterized protein.	0.761
COQ2	chiPu_0030367	A0A401SH48	A0A401TUB4	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Uncharacterized protein.	0.768
COQ2	chiPu_0031691	A0A401SH48	A0A401TYB1	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Uncharacterized protein.	0.947
chiPu_0000939	COQ2	A0A401RWP3	A0A401SH48	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	0.480
chiPu_0000939	chiPu_0004278	A0A401RWP3	A0A401S643	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.891
chiPu_0000939	chiPu_0006922	A0A401RWP3	A0A401SDJ5	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Uncharacterized protein.	0.844
chiPu_0004127	COQ2	A0A401S5Q2	A0A401SH48	Uncharacterized protein.	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	0.761
chiPu_0004127	chiPu_0006922	A0A401S5Q2	A0A401SDJ5	Uncharacterized protein.	Uncharacterized protein.	0.867
chiPu_0004127	chiPu_0021265	A0A401S5Q2	A0A401RPI8	Uncharacterized protein.	Uncharacterized protein.	0.560
chiPu_0004127	chiPu_0030367	A0A401S5Q2	A0A401TUB4	Uncharacterized protein.	Uncharacterized protein.	0.560
chiPu_0004127	chiPu_0031691	A0A401S5Q2	A0A401TYB1	Uncharacterized protein.	Uncharacterized protein.	0.837
chiPu_0004278	COQ2	A0A401S643	A0A401SH48	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	0.480
chiPu_0004278	chiPu_0000939	A0A401S643	A0A401RWP3	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.891

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Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.831

expected number of edges:

11

PPI enrichment p-value:

5.9e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006325

Chromatin organization

4 of 119

1.85

1.78

0.00018

GO:0032968

Positive regulation of transcription elongation from RNA polymerase II promoter

2 of 4

3.02

1.74

0.00071

GO:0006355

Regulation of transcription, DNA-templated

5 of 251

1.62

1.61

0.00018

GO:0006368

Transcription elongation from RNA polymerase II promoter

2 of 9

2.67

1.6

0.0012

GO:0006338

Chromatin remodeling

3 of 66

1.98

1.56

0.00081

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030527

Structural constituent of chromatin

6 of 24

2.72

6.27

8.41e-13

GO:0046982

Protein heterodimerization activity

6 of 34

2.57

5.8

3.62e-12

GO:0046983

Protein dimerization activity

7 of 64

2.36

5.75

8.13e-13

GO:0003677

DNA binding

7 of 402

1.56

2.46

5.24e-08

GO:0005515

Protein binding

8 of 951

1.25

1.65

2.75e-07

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000785

Chromatin

8 of 61

2.44

7.24

4.38e-16

GO:0000786

Nucleosome

6 of 23

2.74

6.48

3.31e-13

GO:0008023

Transcription elongation factor complex

3 of 17

2.57

2.87

4.13e-06

GO:0005654

Nucleoplasm

5 of 174

1.78

2.56

7.49e-07

GO:0016591

RNA polymerase II, holoenzyme

3 of 33

2.28

2.4

2.25e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3820

Nucleosome, and Histone lysine methylation

5 of 19

2.74

4.85

6.94e-10

CL:4247

RNA Polymerase II Transcription Elongation

4 of 13

2.81

4.18

1.63e-08

CL:3822

Nucleosome, and Histone-lysine N-methyltransferase activity

4 of 14

2.78

4.14

1.83e-08

CL:3789

Mixed, incl. Chromatin organization, and Lysine degradation

7 of 193

1.88

3.62

9.69e-10

CL:4263

Cdc73/Paf1 complex, and Positive regulation of transcription elongation from RNA polymerase II promoter

3 of 5

3.1

3.47

4.83e-07

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2299718

Condensation of Prophase Chromosomes

4 of 14

2.78

3.83

7.25e-08

MAP-75955

RNA Polymerase II Transcription Elongation

4 of 41

2.31

3.08

8.77e-07

MAP-68875

Mitotic Prophase

4 of 49

2.23

2.94

1.38e-06

MAP-73886

Chromosome Maintenance

4 of 50

2.22

2.93

1.38e-06

MAP-674695

RNA Polymerase II Pre-transcription Events

4 of 56

2.17

2.87

1.63e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000786

Nucleosome

6 of 23

2.74

6.29

8.10e-13

GOCC:0000785

Chromatin

7 of 86

2.23

5.39

1.38e-12

GOCC:0008023

Transcription elongation factor complex

3 of 20

2.5

2.61

1.22e-05

GOCC:0016591

RNA polymerase II, holoenzyme

3 of 25

2.4

2.49

1.84e-05

GOCC:0016593

Cdc73/Paf1 complex

2 of 3

3.14

2.19

0.00011

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0544

Nucleosome core

6 of 16

2.89

7.1

3.66e-14

KW-0539

Nucleus

7 of 273

1.73

3.29

6.35e-10

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR009072

Histone-fold

6 of 29

2.64

5.61

1.30e-11

IPR007125

Histone H2A/H2B/H3

5 of 17

2.79

4.99

4.06e-10

IPR032458

Histone H2A conserved site

4 of 9

2.97

4.14

2.42e-08

IPR032454

Histone H2A, C-terminal domain

4 of 9

2.97

4.14

2.42e-08

IPR002119

Histone H2A

4 of 9

2.97

4.14

2.42e-08

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00414

Histone 2A

4 of 9

2.97

4.42

7.00e-09

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