chiPu_0008693 protein (Chiloscyllium punctatum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

chiPu_0008693

Uncharacterized protein. (1321 aa)

Predicted Functional Partners:

chiPu_0008694

0.962

chiPu_0014754

0.941

chiPu_0008695

0.940

chiPu_0009927

0.908

chiPu_0002589

0.894

chiPu_0009885

0.885

chiPu_0013402

0.856

chiPu_0002357

0.831

chiPu_0013179

0.726

chiPu_0013551

0.721

Your Current Organism:

Chiloscyllium punctatum

NCBI taxonomy Id: 137246
Other names: C. punctatum, brownbanded bambooshark

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... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
chiPu_0002357	chiPu_0002589	A0A401S0N3	A0A401S1C6	Ion_trans domain-containing protein.	Uncharacterized protein.	0.979
chiPu_0002357	chiPu_0008693	A0A401S0N3	A0A401SIS8	Ion_trans domain-containing protein.	Uncharacterized protein.	0.831
chiPu_0002357	chiPu_0008694	A0A401S0N3	A0A401SIJ3	Ion_trans domain-containing protein.	Ion_trans domain-containing protein.	0.831
chiPu_0002357	chiPu_0008695	A0A401S0N3	A0A401SIL1	Ion_trans domain-containing protein.	Ion_trans domain-containing protein.	0.865
chiPu_0002357	chiPu_0009885	A0A401S0N3	A0A401SM01	Ion_trans domain-containing protein.	Uncharacterized protein.	0.966
chiPu_0002357	chiPu_0009927	A0A401S0N3	A0A401SM54	Ion_trans domain-containing protein.	Ion_trans domain-containing protein.	0.876
chiPu_0002357	chiPu_0013179	A0A401S0N3	A0A401SWC9	Ion_trans domain-containing protein.	Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents.	0.535
chiPu_0002357	chiPu_0013402	A0A401S0N3	A0A401SX02	Ion_trans domain-containing protein.	Ion_trans domain-containing protein.	0.982
chiPu_0002357	chiPu_0014754	A0A401S0N3	A0A401T0V9	Ion_trans domain-containing protein.	Ion_trans domain-containing protein.	0.827
chiPu_0002589	chiPu_0002357	A0A401S1C6	A0A401S0N3	Uncharacterized protein.	Ion_trans domain-containing protein.	0.979
chiPu_0002589	chiPu_0008693	A0A401S1C6	A0A401SIS8	Uncharacterized protein.	Uncharacterized protein.	0.894
chiPu_0002589	chiPu_0008694	A0A401S1C6	A0A401SIJ3	Uncharacterized protein.	Ion_trans domain-containing protein.	0.894
chiPu_0002589	chiPu_0008695	A0A401S1C6	A0A401SIL1	Uncharacterized protein.	Ion_trans domain-containing protein.	0.887
chiPu_0002589	chiPu_0009885	A0A401S1C6	A0A401SM01	Uncharacterized protein.	Uncharacterized protein.	0.990
chiPu_0002589	chiPu_0009927	A0A401S1C6	A0A401SM54	Uncharacterized protein.	Ion_trans domain-containing protein.	0.842
chiPu_0002589	chiPu_0013179	A0A401S1C6	A0A401SWC9	Uncharacterized protein.	Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents.	0.670
chiPu_0002589	chiPu_0013402	A0A401S1C6	A0A401SX02	Uncharacterized protein.	Ion_trans domain-containing protein.	0.982
chiPu_0002589	chiPu_0014754	A0A401S1C6	A0A401T0V9	Uncharacterized protein.	Ion_trans domain-containing protein.	0.892
chiPu_0008693	chiPu_0002357	A0A401SIS8	A0A401S0N3	Uncharacterized protein.	Ion_trans domain-containing protein.	0.831
chiPu_0008693	chiPu_0002589	A0A401SIS8	A0A401S1C6	Uncharacterized protein.	Uncharacterized protein.	0.894

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.913

expected number of edges:

12

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032981

Mitochondrial respiratory chain complex I assembly

6 of 18

2.6

5.4

3.12e-11

GO:0015990

Electron transport coupled proton transport

2 of 2

3.08

1.58

0.0014

GO:0022607

Cellular component assembly

7 of 557

1.18

1.24

5.29e-05

GO:1902600

Proton transmembrane transport

3 of 120

1.48

0.74

0.0287

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008137

NADH dehydrogenase (ubiquinone) activity

4 of 25

2.28

2.57

1.02e-05

GO:0015399

Primary active transmembrane transporter activity

5 of 146

1.61

1.91

1.91e-05

GO:0048038

Quinone binding

2 of 10

2.38

1.2

0.0062

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070469

Respirasome

5 of 59

2.01

2.94

4.40e-07

GO:0005747

Mitochondrial respiratory chain complex I

4 of 25

2.28

2.93

1.74e-06

GO:0098798

Mitochondrial protein-containing complex

5 of 195

1.49

1.72

2.52e-05

GO:0005743

Mitochondrial inner membrane

5 of 272

1.34

1.39

0.00011

GO:0005739

Mitochondrion

10 of 1039

1.06

1.31

8.48e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10257

Respirasome, and NAD(P)H-binding

9 of 91

2.07

5.68

6.58e-15

CL:10427

NADH dehydrogenase complex assembly

4 of 6

2.9

4.4

7.21e-09

CL:10281

Complex I biogenesis

5 of 29

2.31

4.08

5.37e-09

CL:10284

Complex I biogenesis

4 of 24

2.3

3.18

5.29e-07

CL:10287

NADH dehydrogenase complex

3 of 17

2.32

2.27

4.46e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

6 of 148

1.69

2.6

1.56e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6799198

Complex I biogenesis

8 of 34

2.45

7.16

8.18e-16

MAP-611105

Respiratory electron transport

8 of 68

2.15

5.63

6.49e-14

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

8 of 82

2.07

5.24

1.77e-13

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

8 of 173

1.74

3.59

4.11e-11

MAP-1430728

Metabolism

9 of 2359

0.66

0.52

0.0014

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005739

Mitochondrion

8 of 810

1.07

1.12

3.00e-05

GOCC:0043231

Intracellular membrane-bounded organelle

10 of 3298

0.56

0.42

0.0042

GOCC:0005737

Cytoplasm

10 of 3536

0.53

0.4

0.0055

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0520

NAD

3 of 41

1.94

1.44

0.0014

KW-0004

4Fe-4S

2 of 12

2.3

1.16

0.0071

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01058

NADH ubiquinone oxidoreductase, 20 Kd subunit

2 of 2

3.08

1.32

0.0041

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006138

NADH-ubiquinone oxidoreductase, 20 Kd subunit

2 of 2

3.08

1.08

0.0115

IPR006137

NADH:ubiquinone oxidoreductase-like, 20kDa subunit

2 of 2

3.08

1.08

0.0115

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