chiPu_0009575 protein (Chiloscyllium punctatum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

chiPu_0009575

Uncharacterized protein. (1285 aa)

Predicted Functional Partners:

chiPu_0005130

0.783

chiPu_0019403

0.770

chiPu_0005858

0.734

chiPu_0004202

0.732

chiPu_0002968

0.727

chiPu_0010793

0.727

chiPu_0005631

0.726

chiPu_0015951

0.655

chiPu_0020645

0.604

chiPu_0019455

0.604

Your Current Organism:

Chiloscyllium punctatum

NCBI taxonomy Id: 137246
Other names: C. punctatum, brownbanded bambooshark

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
chiPu_0002968	chiPu_0004202	A0A401S2G4	A0A401S5X9	Cytoplasmic protein.	Uncharacterized protein.	0.727
chiPu_0002968	chiPu_0005631	A0A401S2G4	A0A401S9Y0	Cytoplasmic protein.	Uncharacterized protein.	0.595
chiPu_0002968	chiPu_0005858	A0A401S2G4	A0A401SAR0	Cytoplasmic protein.	Protein kinase domain-containing protein.	0.595
chiPu_0002968	chiPu_0009575	A0A401S2G4	A0A401SL64	Cytoplasmic protein.	Uncharacterized protein.	0.727
chiPu_0002968	chiPu_0010793	A0A401S2G4	A0A401SPM0	Cytoplasmic protein.	Cytoplasmic protein.	0.890
chiPu_0002968	chiPu_0019455	A0A401S2G4	A0A401RRW6	Cytoplasmic protein.	Uncharacterized protein.	0.600
chiPu_0002968	chiPu_0020645	A0A401S2G4	A0A401RHV1	Cytoplasmic protein.	Uncharacterized protein.	0.600
chiPu_0004202	chiPu_0002968	A0A401S5X9	A0A401S2G4	Uncharacterized protein.	Cytoplasmic protein.	0.727
chiPu_0004202	chiPu_0005130	A0A401S5X9	A0A401S8J3	Uncharacterized protein.	Uncharacterized protein.	0.843
chiPu_0004202	chiPu_0005631	A0A401S5X9	A0A401S9Y0	Uncharacterized protein.	Uncharacterized protein.	0.726
chiPu_0004202	chiPu_0005858	A0A401S5X9	A0A401SAR0	Uncharacterized protein.	Protein kinase domain-containing protein.	0.733
chiPu_0004202	chiPu_0009575	A0A401S5X9	A0A401SL64	Uncharacterized protein.	Uncharacterized protein.	0.732
chiPu_0004202	chiPu_0010793	A0A401S5X9	A0A401SPM0	Uncharacterized protein.	Cytoplasmic protein.	0.727
chiPu_0004202	chiPu_0015951	A0A401S5X9	A0A401T4A8	Uncharacterized protein.	Uncharacterized protein.	0.655
chiPu_0004202	chiPu_0019403	A0A401S5X9	A0A401RRS0	Uncharacterized protein.	TNF receptor-associated factor.	0.770
chiPu_0004202	chiPu_0019455	A0A401S5X9	A0A401RRW6	Uncharacterized protein.	Uncharacterized protein.	0.604
chiPu_0004202	chiPu_0020645	A0A401S5X9	A0A401RHV1	Uncharacterized protein.	Uncharacterized protein.	0.604
chiPu_0005130	chiPu_0004202	A0A401S8J3	A0A401S5X9	Uncharacterized protein.	Uncharacterized protein.	0.843
chiPu_0005130	chiPu_0009575	A0A401S8J3	A0A401SL64	Uncharacterized protein.	Uncharacterized protein.	0.783
chiPu_0005130	chiPu_0015951	A0A401S8J3	A0A401T4A8	Uncharacterized protein.	Uncharacterized protein.	0.577

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.875

expected number of edges:

42

PPI enrichment p-value:

0.998

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000160

Phosphorelay signal transduction system

8 of 82

1.4

2.03

1.16e-07

GO:0006355

Regulation of transcription, DNA-templated

7 of 133

1.13

1.24

1.59e-05

GO:0050896

Response to stimulus

9 of 226

1.01

1.14

1.27e-06

GO:0050794

Regulation of cellular process

9 of 241

0.98

1.08

1.89e-06

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043565

Sequence-specific DNA binding

5 of 22

1.77

2.14

1.31e-05

GO:0003677

DNA binding

7 of 194

0.97

0.84

0.00058

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1982

Sigma-54 interaction domain, ATP-binding site 1, and Alpha/beta hydrolase fold-1

4 of 11

1.97

2.16

3.42e-05

CL:1804

His Kinase A (phosphoacceptor) domain, and cheY-homologous receiver domain

9 of 100

1.37

2.14

4.16e-09

CL:1803

Mixed, incl. Signaling, and Cilium

10 of 174

1.17

1.64

4.16e-09

CL:1819

PAS-associated, C-terminal, and cheY-homologous receiver domain

4 of 40

1.41

1.18

0.0013

CL:1811

His Kinase A (phosphoacceptor) domain, and cheY-homologous receiver domain

5 of 70

1.27

1.13

0.00072

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

mro02020

Two-component system

5 of 71

1.26

1.16

0.00048

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

7 of 70

1.41

1.95

5.02e-07

KW-0805

Transcription regulation

4 of 73

1.15

0.8

0.0073

KW-0067

ATP-binding

7 of 231

0.89

0.76

0.00067

KW-0238

DNA-binding

4 of 111

0.97

0.58

0.0231

KW-0418

Kinase

4 of 132

0.89

0.5

0.0374

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02954

Bacterial regulatory protein, Fis family

3 of 11

1.85

1.08

0.0073

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001789

Signal transduction response regulator, receiver domain

7 of 62

1.46

1.97

1.38e-06

IPR011006

CheY-like superfamily

7 of 63

1.46

1.96

1.38e-06

IPR002078

RNA polymerase sigma factor 54 interaction domain

4 of 15

1.84

1.76

0.00019

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

5 of 55

1.37

1.27

0.00046

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

5 of 55

1.37

1.27

0.00046

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00448

cheY-homologous receiver domain

7 of 59

1.49

2.24

9.11e-08

SM00388

His Kinase A (phosphoacceptor) domain

6 of 59

1.42

1.83

2.70e-06

SM00382

ATPases associated with a variety of cellular activities

4 of 61

1.23

0.95

0.0028

SM00091

PAS domain

3 of 33

1.37

0.94

0.0065

SM00387

Histidine kinase-like ATPases

4 of 68

1.18

0.91

0.0031

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