chiPu_0014551 protein (Chiloscyllium punctatum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

chiPu_0014551

Uncharacterized protein. (204 aa)

Predicted Functional Partners:

chiPu_0016068

0.962

chiPu_0009386

0.794

chiPu_0009929

0.784

chiPu_0008264

0.783

chiPu_0009855

0.771

chiPu_0002441

0.712

chiPu_0007875

0.712

chiPu_0009387

0.711

chiPu_0014227

0.711

chiPu_0006281

0.708

Your Current Organism:

Chiloscyllium punctatum

NCBI taxonomy Id: 137246
Other names: C. punctatum, brownbanded bambooshark

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
chiPu_0002441	chiPu_0006281	A0A401S0V8	A0A401SBS4	DUF1619 domain-containing protein.	Uncharacterized protein.	0.798
chiPu_0002441	chiPu_0008264	A0A401S0V8	A0A401SHD2	DUF1619 domain-containing protein.	Uncharacterized protein.	0.864
chiPu_0002441	chiPu_0009386	A0A401S0V8	A0A401SKL2	DUF1619 domain-containing protein.	Uncharacterized protein.	0.747
chiPu_0002441	chiPu_0009387	A0A401S0V8	A0A401SKL7	DUF1619 domain-containing protein.	Uncharacterized protein.	0.567
chiPu_0002441	chiPu_0009855	A0A401S0V8	A0A401SLZ5	DUF1619 domain-containing protein.	Uncharacterized protein.	0.950
chiPu_0002441	chiPu_0009929	A0A401S0V8	A0A401SM69	DUF1619 domain-containing protein.	Uncharacterized protein.	0.924
chiPu_0002441	chiPu_0014227	A0A401S0V8	A0A401SZC6	DUF1619 domain-containing protein.	DUF1619 domain-containing protein.	0.700
chiPu_0002441	chiPu_0014551	A0A401S0V8	A0A401T095	DUF1619 domain-containing protein.	Uncharacterized protein.	0.712
chiPu_0002441	chiPu_0016068	A0A401S0V8	A0A401T4P4	DUF1619 domain-containing protein.	Uncharacterized protein.	0.712
chiPu_0006281	chiPu_0002441	A0A401SBS4	A0A401S0V8	Uncharacterized protein.	DUF1619 domain-containing protein.	0.798
chiPu_0006281	chiPu_0007875	A0A401SBS4	A0A401SGG2	Uncharacterized protein.	DUF1619 domain-containing protein.	0.798
chiPu_0006281	chiPu_0008264	A0A401SBS4	A0A401SHD2	Uncharacterized protein.	Uncharacterized protein.	0.837
chiPu_0006281	chiPu_0009386	A0A401SBS4	A0A401SKL2	Uncharacterized protein.	Uncharacterized protein.	0.814
chiPu_0006281	chiPu_0009855	A0A401SBS4	A0A401SLZ5	Uncharacterized protein.	Uncharacterized protein.	0.832
chiPu_0006281	chiPu_0009929	A0A401SBS4	A0A401SM69	Uncharacterized protein.	Uncharacterized protein.	0.881
chiPu_0006281	chiPu_0014227	A0A401SBS4	A0A401SZC6	Uncharacterized protein.	DUF1619 domain-containing protein.	0.717
chiPu_0006281	chiPu_0014551	A0A401SBS4	A0A401T095	Uncharacterized protein.	Uncharacterized protein.	0.708
chiPu_0006281	chiPu_0016068	A0A401SBS4	A0A401T4P4	Uncharacterized protein.	Uncharacterized protein.	0.708
chiPu_0007875	chiPu_0006281	A0A401SGG2	A0A401SBS4	DUF1619 domain-containing protein.	Uncharacterized protein.	0.798
chiPu_0007875	chiPu_0008264	A0A401SGG2	A0A401SHD2	DUF1619 domain-containing protein.	Uncharacterized protein.	0.864

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.968

expected number of edges:

11

PPI enrichment p-value:

3.84e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006525

Arginine metabolic process

11 of 34

2.23

8.23

2.82e-21

GO:0006526

Arginine biosynthetic process

9 of 17

2.45

8.04

4.90e-18

GO:0006591

Ornithine metabolic process

4 of 6

2.55

3.56

1.65e-07

GO:0042450

Arginine biosynthetic process via ornithine

2 of 2

2.72

1.57

0.0014

GO:0044205

De novo UMP biosynthetic process

2 of 7

2.18

1.12

0.0079

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0103045

Methione N-acyltransferase activity

2 of 2

2.72

0.93

0.0203

GO:0004088

Carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity

2 of 2

2.72

0.93

0.0203

GO:0004042

acetyl-CoA:L-glutamate N-acetyltransferase activity

2 of 2

2.72

0.93

0.0203

GO:0016774

Phosphotransferase activity, carboxyl group as acceptor

2 of 7

2.18

0.82

0.0303

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

3 of 51

1.49

0.73

0.0303

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 1829

0.5

0.42

0.00052

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1505

Arginine biosynthesis, and Amino acid antiporter

9 of 15

2.5

8.22

4.37e-18

CL:1510

Arginine biosynthesis

6 of 6

2.72

6.12

1.70e-12

CL:1367

Cellular amino acid biosynthetic process, and Ribonucleoside monophosphate biosynthetic process

11 of 152

1.58

3.6

3.78e-15

CL:1525

Amino acid antiporter, and Arginine catabolic process to ornithine

2 of 5

2.33

1.03

0.0127

CL:1578

Pyrimidine biosynthesis, and Dihydroorotase, conserved site

2 of 6

2.25

0.99

0.0148

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pfn00220

Arginine biosynthesis

9 of 36

2.12

6.25

3.12e-16

pfn00250

Alanine, aspartate and glutamate metabolism

4 of 39

1.74

1.95

3.78e-05

pfn01230

Biosynthesis of amino acids

7 of 179

1.32

1.75

6.17e-07

pfn01210

2-Oxocarboxylic acid metabolism

4 of 51

1.62

1.75

6.84e-05

pfn01110

Biosynthesis of secondary metabolites

8 of 614

0.84

0.78

6.84e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005951

Carbamoyl-phosphate synthase complex

2 of 2

2.72

1.18

0.0073

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0055

Arginine biosynthesis

9 of 13

2.56

8.87

2.96e-19

KW-0963

Cytoplasm

8 of 311

1.13

1.38

8.14e-07

KW-0665

Pyrimidine biosynthesis

2 of 10

2.03

1.0

0.0124

KW-0436

Ligase

3 of 73

1.34

0.8

0.0152

KW-0808

Transferase

5 of 407

0.81

0.51

0.0216

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00696

Amino acid kinase family

3 of 6

2.42

1.85

0.00035

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036393

Acetylglutamate kinase-like superfamily

3 of 6

2.42

1.71

0.00065

IPR001048

Aspartate/glutamate/uridylate kinase

3 of 6

2.42

1.71

0.00065

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