chiPu_0016173 protein (Chiloscyllium punctatum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

chiPu_0016173

BH4_AAA_HYDROXYL_2 domain-containing protein. (52 aa)

Predicted Functional Partners:

chiPu_0002358

0.959

chiPu_0011519

0.959

chiPu_0014089

0.905

chiPu_0019019

0.891

chiPu_0011969

0.885

chiPu_0014234

0.885

chiPu_0020400

0.878

chiPu_0014207

0.877

chiPu_0020530

0.857

chiPu_0000964

0.857

Your Current Organism:

Chiloscyllium punctatum

NCBI taxonomy Id: 137246
Other names: C. punctatum, brownbanded bambooshark

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
chiPu_0000964	chiPu_0011969	A0A401RWQ0	A0A401SSY4	Uncharacterized protein.	Aspartate aminotransferase.	0.824
chiPu_0000964	chiPu_0014089	A0A401RWQ0	A0A401SZ08	Uncharacterized protein.	Aspartate aminotransferase.	0.859
chiPu_0000964	chiPu_0014234	A0A401RWQ0	A0A401SZD6	Uncharacterized protein.	Aspartate aminotransferase.	0.824
chiPu_0000964	chiPu_0016173	A0A401RWQ0	A0A401T4U0	Uncharacterized protein.	BH4_AAA_HYDROXYL_2 domain-containing protein.	0.857
chiPu_0000964	chiPu_0019019	A0A401RWQ0	A0A401RQG8	Uncharacterized protein.	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.	0.862
chiPu_0002358	chiPu_0011519	A0A401S0T8	A0A401SRQ8	Uncharacterized protein.	Uncharacterized protein.	0.890
chiPu_0002358	chiPu_0011969	A0A401S0T8	A0A401SSY4	Uncharacterized protein.	Aspartate aminotransferase.	0.573
chiPu_0002358	chiPu_0014089	A0A401S0T8	A0A401SZ08	Uncharacterized protein.	Aspartate aminotransferase.	0.682
chiPu_0002358	chiPu_0014207	A0A401S0T8	A0A401SZA5	Uncharacterized protein.	Uncharacterized protein.	0.878
chiPu_0002358	chiPu_0014234	A0A401S0T8	A0A401SZD6	Uncharacterized protein.	Aspartate aminotransferase.	0.573
chiPu_0002358	chiPu_0016173	A0A401S0T8	A0A401T4U0	Uncharacterized protein.	BH4_AAA_HYDROXYL_2 domain-containing protein.	0.959
chiPu_0002358	chiPu_0020400	A0A401S0T8	A0A401RFC8	Uncharacterized protein.	Uncharacterized protein.	0.642
chiPu_0011519	chiPu_0002358	A0A401SRQ8	A0A401S0T8	Uncharacterized protein.	Uncharacterized protein.	0.890
chiPu_0011519	chiPu_0011969	A0A401SRQ8	A0A401SSY4	Uncharacterized protein.	Aspartate aminotransferase.	0.573
chiPu_0011519	chiPu_0014089	A0A401SRQ8	A0A401SZ08	Uncharacterized protein.	Aspartate aminotransferase.	0.682
chiPu_0011519	chiPu_0014207	A0A401SRQ8	A0A401SZA5	Uncharacterized protein.	Uncharacterized protein.	0.878
chiPu_0011519	chiPu_0014234	A0A401SRQ8	A0A401SZD6	Uncharacterized protein.	Aspartate aminotransferase.	0.573
chiPu_0011519	chiPu_0016173	A0A401SRQ8	A0A401T4U0	Uncharacterized protein.	BH4_AAA_HYDROXYL_2 domain-containing protein.	0.959
chiPu_0011519	chiPu_0020400	A0A401SRQ8	A0A401RFC8	Uncharacterized protein.	Uncharacterized protein.	0.642
chiPu_0011969	chiPu_0000964	A0A401SSY4	A0A401RWQ0	Aspartate aminotransferase.	Uncharacterized protein.	0.824

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.915

expected number of edges:

13

PPI enrichment p-value:

0.00139

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030198

Extracellular matrix organization

3 of 3

2.58

1.93

0.00027

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008658

Penicillin binding

6 of 22

2.02

3.53

1.27e-08

GO:0005201

Extracellular matrix structural constituent

3 of 3

2.58

2.5

2.21e-05

GO:0008955

Peptidoglycan glycosyltransferase activity

2 of 5

2.19

1.08

0.0095

GO:0009002

Serine-type D-Ala-D-Ala carboxypeptidase activity

2 of 9

1.93

0.87

0.0220

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031012

Extracellular matrix

3 of 3

2.58

2.43

2.96e-05

GO:0005615

Extracellular space

3 of 3

2.58

2.43

2.96e-05

GO:0005887

Integral component of plasma membrane

4 of 78

1.29

1.11

0.0011

GO:0071944

Cell periphery

7 of 655

0.61

0.44

0.0067

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2028

Mixed, incl. Penicillin-binding protein, transpeptidase, and Peptidase S11, D-Ala-D-Ala carboxypeptidase A, C-terminal

6 of 12

2.28

4.57

3.03e-10

CL:1996

Peptidoglycan biosynthesis, and Alanine racemase

7 of 29

1.97

4.01

2.39e-10

CL:2030

Penicillin-binding protein, transpeptidase, and Cell cycle, FtsW / RodA / SpoVE, conserved site

4 of 6

2.41

3.28

4.40e-07

CL:1986

Mixed, incl. Peptidoglycan biosynthesis, and Extracellular region

10 of 140

1.44

2.62

2.11e-11

CL:2169

Mixed, incl. Extracellular space, and Xylanase activity

3 of 20

1.76

1.34

0.0017

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00550

Peptidoglycan biosynthesis

6 of 42

1.74

2.79

7.49e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005576

Extracellular region

4 of 98

1.2

0.69

0.0221

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00905

Penicillin binding protein transpeptidase domain

4 of 7

2.34

2.78

4.06e-06

PF03717

Penicillin-binding Protein dimerisation domain

3 of 3

2.58

2.25

6.54e-05

PF01391

Collagen triple helix repeat (20 copies)

2 of 3

2.41

1.08

0.0102

PF00912

Transglycosylase

2 of 4

2.28

1.05

0.0115

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001460

Penicillin-binding protein, transpeptidase

4 of 7

2.34

2.59

1.01e-05

IPR036138

Penicillin-binding protein, dimerisation domain superfamily

3 of 3

2.58

2.14

0.00011

IPR005311

Penicillin-binding protein, dimerisation domain

3 of 3

2.58

2.14

0.00011

IPR012338

Beta-lactamase/transpeptidase-like

4 of 17

1.96

1.97

9.00e-05

IPR008160

Collagen triple helix repeat

2 of 2

2.58

1.12

0.0092

(more ...)

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