chiPu_0016514 protein (Chiloscyllium punctatum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

chiPu_0016514

Uncharacterized protein. (975 aa)

Predicted Functional Partners:

chiPu_0007861

0.977

chiPu_0010159

0.970

chiPu_0006018

0.953

chiPu_0007977

0.950

chiPu_0015704

0.950

chiPu_0019714

0.942

chiPu_0000741

0.942

chiPu_0024546

0.942

chiPu_0022639

0.938

chiPu_0021841

0.938

Your Current Organism:

Chiloscyllium punctatum

NCBI taxonomy Id: 137246
Other names: C. punctatum, brownbanded bambooshark

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
chiPu_0000741	chiPu_0006018	A0A401RW19	A0A401SB43	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	BRCT domain-containing protein.	0.994
chiPu_0000741	chiPu_0007861	A0A401RW19	A0A401SG81	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Non-specific serine/threonine protein kinase.	0.996
chiPu_0000741	chiPu_0007977	A0A401RW19	A0A401SGQ3	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	PWWP domain-containing protein.	0.989
chiPu_0000741	chiPu_0010159	A0A401RW19	A0A401SMV0	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.999
chiPu_0000741	chiPu_0016514	A0A401RW19	A0A401T5Q3	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Uncharacterized protein.	0.942
chiPu_0000741	chiPu_0024546	A0A401RW19	A0A401TDF0	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	FHA domain-containing protein.	0.866
chiPu_0006018	chiPu_0000741	A0A401SB43	A0A401RW19	BRCT domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.994
chiPu_0006018	chiPu_0007861	A0A401SB43	A0A401SG81	BRCT domain-containing protein.	Non-specific serine/threonine protein kinase.	0.925
chiPu_0006018	chiPu_0007977	A0A401SB43	A0A401SGQ3	BRCT domain-containing protein.	PWWP domain-containing protein.	0.925
chiPu_0006018	chiPu_0010159	A0A401SB43	A0A401SMV0	BRCT domain-containing protein.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.997
chiPu_0006018	chiPu_0016514	A0A401SB43	A0A401T5Q3	BRCT domain-containing protein.	Uncharacterized protein.	0.953
chiPu_0007861	chiPu_0000741	A0A401SG81	A0A401RW19	Non-specific serine/threonine protein kinase.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.996
chiPu_0007861	chiPu_0006018	A0A401SG81	A0A401SB43	Non-specific serine/threonine protein kinase.	BRCT domain-containing protein.	0.925
chiPu_0007861	chiPu_0010159	A0A401SG81	A0A401SMV0	Non-specific serine/threonine protein kinase.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.998
chiPu_0007861	chiPu_0016514	A0A401SG81	A0A401T5Q3	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.977
chiPu_0007861	chiPu_0024546	A0A401SG81	A0A401TDF0	Non-specific serine/threonine protein kinase.	FHA domain-containing protein.	0.845
chiPu_0007977	chiPu_0000741	A0A401SGQ3	A0A401RW19	PWWP domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.989
chiPu_0007977	chiPu_0006018	A0A401SGQ3	A0A401SB43	PWWP domain-containing protein.	BRCT domain-containing protein.	0.925
chiPu_0007977	chiPu_0010159	A0A401SGQ3	A0A401SMV0	PWWP domain-containing protein.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.989
chiPu_0007977	chiPu_0016514	A0A401SGQ3	A0A401T5Q3	PWWP domain-containing protein.	Uncharacterized protein.	0.950

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.852

expected number of edges:

14

PPI enrichment p-value:

4.66e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006099

Tricarboxylic acid cycle

4 of 23

1.94

1.8

0.00021

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004775

succinate-CoA ligase (ADP-forming) activity

3 of 4

2.57

2.05

0.00016

GO:0016874

Ligase activity

4 of 148

1.13

0.64

0.0245

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045239

Tricarboxylic acid cycle enzyme complex

3 of 5

2.47

2.29

4.96e-05

GO:0009361

succinate-CoA ligase complex (ADP-forming)

2 of 3

2.52

1.4

0.0027

GO:1902494

Catalytic complex

3 of 104

1.15

0.62

0.0323

GO:0032991

Protein-containing complex

4 of 232

0.93

0.53

0.0323

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7774

succinate-CoA ligase complex, and Purine catabolism PurC-like domain

5 of 5

2.69

4.6

1.88e-09

CL:7705

Aromatic compound catabolic process, and PucR C-terminal helix-turn-helix domain

7 of 45

1.89

3.55

1.88e-09

CL:7712

Mixed, incl. Aldehyde oxidase/xanthine dehydrogenase, and Molybdopterin dehydrogenase, FAD-binding

2 of 7

2.15

0.88

0.0236

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045239

Tricarboxylic acid cycle enzyme complex

4 of 6

2.52

3.27

5.90e-07

GOCC:0042709

succinate-CoA ligase complex

3 of 4

2.57

2.4

3.36e-05

GOCC:0009361

succinate-CoA ligase complex (ADP-forming)

2 of 3

2.52

1.31

0.0039

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00549

CoA-ligase

2 of 3

2.52

0.86

0.0267

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (28%) [HD]

Permalink

Credits

Access

Info

About

STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About