chiPu_0023630 protein (Chiloscyllium punctatum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

chiPu_0023630

Uncharacterized protein. (109 aa)

Predicted Functional Partners:

chiPu_0019714

0.950

chiPu_0020560

0.918

chiPu_0025629

0.918

chiPu_0022245

0.915

chiPu_0032064

0.915

chiPu_0022605

0.912

chiPu_0020912

0.912

chiPu_0016306

0.900

chiPu_0006527

0.886

chiPu_0010066

0.886

Your Current Organism:

Chiloscyllium punctatum

NCBI taxonomy Id: 137246
Other names: C. punctatum, brownbanded bambooshark

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
chiPu_0006527	chiPu_0010066	A0A401SCJ0	A0A401SMK9	Uncharacterized protein.	Uncharacterized protein.	0.924
chiPu_0006527	chiPu_0016306	A0A401SCJ0	A0A401T586	Uncharacterized protein.	Uncharacterized protein.	0.992
chiPu_0006527	chiPu_0019714	A0A401SCJ0	A0A401RSX8	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.727
chiPu_0006527	chiPu_0020560	A0A401SCJ0	A0A401RH00	Uncharacterized protein.	B30.2/SPRY domain-containing protein.	0.672
chiPu_0006527	chiPu_0020912	A0A401SCJ0	A0A401RL75	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.632
chiPu_0006527	chiPu_0022605	A0A401SCJ0	A0A401RFS2	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.632
chiPu_0006527	chiPu_0023630	A0A401SCJ0	A0A401TAM0	Uncharacterized protein.	Uncharacterized protein.	0.886
chiPu_0006527	chiPu_0025629	A0A401SCJ0	A0A401TH26	Uncharacterized protein.	Uncharacterized protein.	0.672
chiPu_0010066	chiPu_0006527	A0A401SMK9	A0A401SCJ0	Uncharacterized protein.	Uncharacterized protein.	0.924
chiPu_0010066	chiPu_0016306	A0A401SMK9	A0A401T586	Uncharacterized protein.	Uncharacterized protein.	0.992
chiPu_0010066	chiPu_0019714	A0A401SMK9	A0A401RSX8	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.727
chiPu_0010066	chiPu_0020560	A0A401SMK9	A0A401RH00	Uncharacterized protein.	B30.2/SPRY domain-containing protein.	0.672
chiPu_0010066	chiPu_0020912	A0A401SMK9	A0A401RL75	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.632
chiPu_0010066	chiPu_0022605	A0A401SMK9	A0A401RFS2	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.632
chiPu_0010066	chiPu_0023630	A0A401SMK9	A0A401TAM0	Uncharacterized protein.	Uncharacterized protein.	0.886
chiPu_0010066	chiPu_0025629	A0A401SMK9	A0A401TH26	Uncharacterized protein.	Uncharacterized protein.	0.672
chiPu_0016306	chiPu_0006527	A0A401T586	A0A401SCJ0	Uncharacterized protein.	Uncharacterized protein.	0.992
chiPu_0016306	chiPu_0010066	A0A401T586	A0A401SMK9	Uncharacterized protein.	Uncharacterized protein.	0.992
chiPu_0016306	chiPu_0019714	A0A401T586	A0A401RSX8	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.758
chiPu_0016306	chiPu_0020560	A0A401T586	A0A401RH00	Uncharacterized protein.	B30.2/SPRY domain-containing protein.	0.719

page 1 of 5

Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070330

Aromatase activity

3 of 11

2.61

1.99

0.00021

GO:0020037

Heme binding

4 of 113

1.73

1.42

0.00099

GO:0005506

Iron ion binding

3 of 127

1.55

0.73

0.0319

GO:0003824

Catalytic activity

10 of 5203

0.46

0.31

0.0319

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30660177

(2019) Isolation of blue-green eggshell pigmentation-related genes from Putian duck through RNA-seq.

4 of 25

2.38

2.49

1.79e-05

PMID:33782952

(2021) Antimicrobial prescribing guidelines for poultry.

2 of 2

3.18

1.14

0.0088

PMID:34214746

(2021) Protective effect of glutathione S-transferase enzyme activity against aflatoxin B1 in poultry species: relationship between glutathione S-transferase enzyme kinetic parameters, and resistance to aflatoxin B1.

2 of 5

2.78

0.93

0.0204

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9381

Mixed, incl. Sulfation, and Epoxygenase P450 pathway

4 of 23

2.42

2.71

6.67e-06

CL:9383

Sulfation, and Epoxygenase P450 pathway

3 of 8

2.75

2.28

6.55e-05

CL:8025

Cytochrome P450, E-class, CYP3A, and Cytochrome P450, E-class, group I, CYP1

2 of 5

2.78

1.1

0.0103

CL:8590

Protoporphyrinogen IX biosynthetic process, and Heme transport

2 of 12

2.4

0.81

0.0333

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

apla00591

Linoleic acid metabolism

2 of 13

2.37

1.17

0.0069

apla00980

Metabolism of xenobiotics by cytochrome P450

2 of 22

2.14

1.09

0.0090

apla00830

Retinol metabolism

2 of 23

2.12

1.09

0.0090

apla00140

Steroid hormone biosynthesis

2 of 27

2.05

1.08

0.0090

apla01100

Metabolic pathways

5 of 996

0.88

0.61

0.0090

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-211859

Biological oxidations

8 of 192

1.8

3.67

1.02e-10

MAP-9749641

Aspirin ADME

4 of 21

2.46

3.12

1.09e-06

MAP-5423646

Aflatoxin activation and detoxification

3 of 14

2.51

2.19

8.12e-05

MAP-9757110

Prednisone ADME

3 of 20

2.36

2.11

0.00010

MAP-156580

Phase II - Conjugation of compounds

4 of 77

1.89

1.95

8.12e-05

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0503

Monooxygenase

3 of 43

2.02

1.53

0.0010

KW-0349

Heme

3 of 60

1.88

1.43

0.0013

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00067

Cytochrome P450

3 of 45

2.0

1.12

0.0071

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR008072

Cytochrome P450, E-class, CYP3A

2 of 2

3.18

1.07

0.0118

IPR002402

Cytochrome P450, E-class, group II

2 of 2

3.18

1.07

0.0118

IPR017972

Cytochrome P450, conserved site

3 of 36

2.1

1.02

0.0118

IPR036396

Cytochrome P450 superfamily

3 of 46

1.99

1.01

0.0118

IPR001128

Cytochrome P450

3 of 45

2.0

1.01

0.0118

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