Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
NGFNerve growth factor; Belongs to the NGF-beta family. (242 aa)    
Predicted Functional Partners:
NTRK1
Tyrosine-protein kinase receptor.
     
 0.952
NTRK2
Tyrosine-protein kinase receptor.
     
 0.818
NTRK3
Neurotrophic receptor tyrosine kinase 3.
     
 0.818
NGFR
Nerve growth factor receptor.
     
 0.777
PDGFRA
Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.
  
  
  0.713
INSR
Tyrosine-protein kinase receptor.
     
  0.669
EPHA2
Receptor protein-tyrosine kinase.
     
  0.669
IGF1R
Tyrosine-protein kinase receptor.
     
  0.669
MET
MET proto-oncogene, receptor tyrosine kinase.
     
  0.669
PCSK4
Proprotein convertase subtilisin/kexin type 4.
     
  0.660
Your Current Organism:
Pelodiscus sinensis
NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38
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