STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)    
Predicted Functional Partners:
PDGFRA
Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.
    
 0.978
PDGFB
Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.
   
0.967
PDGFRB
Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    
 0.944
VEGFC
Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.
     
 0.909
EGF
Epidermal growth factor.
     
 0.904
VEGFB
PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.
     
0.902
ERBB3
Recep_L_domain domain-containing protein.
    
  0.901
EGFR
Receptor protein-tyrosine kinase.
    
  0.901
VEGFD
Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.
     
 0.901
HGF
Hepatocyte growth factor; Belongs to the peptidase S1 family.
     
  0.901
Your Current Organism:
Pelodiscus sinensis
NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.