STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMYD5SMYD family member 5. (358 aa)    
Predicted Functional Partners:
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.699
SMYD4
SET and MYND domain containing 4.
      
 0.605
EED
Embryonic ectoderm development.
    
 0.580
RBBP5
RB binding protein 5, histone lysine methyltransferase complex subunit.
    
 0.563
ASH2L
ASH2 like, histone lysine methyltransferase complex subunit.
    
 0.563
SUZ12
SUZ12 polycomb repressive complex 2 subunit.
    
 0.559
MPHOSPH8
M-phase phosphoprotein 8.
    
 0.535
SETD3
Protein-histidine N-methyltransferase.
   
 
 0.512
K7FUK6_PELSI
JmjC domain-containing protein.
   
 0.500
KDM6A
Uncharacterized protein.
   
 0.500
Your Current Organism:
Pelodiscus sinensis
NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.