node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SEQ63837.1 | murI | SAMN05421767_1035 | SAMN05421767_1036 | Hypothetical protein. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis; Belongs to the aspartate/glutamate racemases family. | 0.935 |
SEQ84359.1 | SER17285.1 | SAMN05421767_10847 | SAMN05421767_1239 | Hypoxanthine phosphoribosyltransferase/bifunctional protein TilS/HprT; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Purine operon repressor, PurR. | 0.643 |
SEQ84359.1 | SER35205.1 | SAMN05421767_10847 | SAMN05421767_13916 | Hypoxanthine phosphoribosyltransferase/bifunctional protein TilS/HprT; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | CBS domain-containing protein. | 0.609 |
SEQ84359.1 | apt | SAMN05421767_10847 | SAMN05421767_10132 | Hypoxanthine phosphoribosyltransferase/bifunctional protein TilS/HprT; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.960 |
SEQ84359.1 | guaA | SAMN05421767_10847 | SAMN05421767_1105 | Hypoxanthine phosphoribosyltransferase/bifunctional protein TilS/HprT; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.968 |
SEQ84359.1 | guaB | SAMN05421767_10847 | SAMN05421767_12527 | Hypoxanthine phosphoribosyltransferase/bifunctional protein TilS/HprT; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.963 |
SEQ84359.1 | guaC | SAMN05421767_10847 | SAMN05421767_1483 | Hypoxanthine phosphoribosyltransferase/bifunctional protein TilS/HprT; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.943 |
SEQ84359.1 | murI | SAMN05421767_10847 | SAMN05421767_1036 | Hypoxanthine phosphoribosyltransferase/bifunctional protein TilS/HprT; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis; Belongs to the aspartate/glutamate racemases family. | 0.923 |
SEQ84359.1 | xpt | SAMN05421767_10847 | SAMN05421767_1188 | Hypoxanthine phosphoribosyltransferase/bifunctional protein TilS/HprT; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.955 |
SER17285.1 | SEQ84359.1 | SAMN05421767_1239 | SAMN05421767_10847 | Purine operon repressor, PurR. | Hypoxanthine phosphoribosyltransferase/bifunctional protein TilS/HprT; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.643 |
SER17285.1 | SER35205.1 | SAMN05421767_1239 | SAMN05421767_13916 | Purine operon repressor, PurR. | CBS domain-containing protein. | 0.525 |
SER17285.1 | apt | SAMN05421767_1239 | SAMN05421767_10132 | Purine operon repressor, PurR. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.637 |
SER17285.1 | guaA | SAMN05421767_1239 | SAMN05421767_1105 | Purine operon repressor, PurR. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.971 |
SER17285.1 | guaB | SAMN05421767_1239 | SAMN05421767_12527 | Purine operon repressor, PurR. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.899 |
SER17285.1 | guaC | SAMN05421767_1239 | SAMN05421767_1483 | Purine operon repressor, PurR. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.622 |
SER17285.1 | murI | SAMN05421767_1239 | SAMN05421767_1036 | Purine operon repressor, PurR. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis; Belongs to the aspartate/glutamate racemases family. | 0.902 |
SER17285.1 | xpt | SAMN05421767_1239 | SAMN05421767_1188 | Purine operon repressor, PurR. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.600 |
SER35205.1 | SEQ84359.1 | SAMN05421767_13916 | SAMN05421767_10847 | CBS domain-containing protein. | Hypoxanthine phosphoribosyltransferase/bifunctional protein TilS/HprT; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.609 |
SER35205.1 | SER17285.1 | SAMN05421767_13916 | SAMN05421767_1239 | CBS domain-containing protein. | Purine operon repressor, PurR. | 0.525 |
SER35205.1 | apt | SAMN05421767_13916 | SAMN05421767_10132 | CBS domain-containing protein. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.525 |