node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CQ394_17485 | clpP | GCA_001458595_00682 | GCA_001458595_01871 | Unannotated protein; Belongs to the ClpA/ClpB family. | Unannotated protein; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.966 |
CQ394_17485 | clpX | GCA_001458595_00682 | GCA_001458595_01872 | Unannotated protein; Belongs to the ClpA/ClpB family. | Unannotated protein; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.553 |
CQ394_17485 | groL | GCA_001458595_00682 | GCA_001458595_00445 | Unannotated protein; Belongs to the ClpA/ClpB family. | Unannotated protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.859 |
CQ394_17485 | groS | GCA_001458595_00682 | GCA_001458595_00446 | Unannotated protein; Belongs to the ClpA/ClpB family. | Unannotated protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.833 |
CQ394_17485 | grpE | GCA_001458595_00682 | GCA_001458595_03643 | Unannotated protein; Belongs to the ClpA/ClpB family. | Unannotated protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depe [...] | 0.901 |
CQ394_17485 | hrcA | GCA_001458595_00682 | GCA_001458595_03644 | Unannotated protein; Belongs to the ClpA/ClpB family. | Unannotated protein; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.876 |
CQ394_17485 | lon | GCA_001458595_00682 | GCA_001458595_01874 | Unannotated protein; Belongs to the ClpA/ClpB family. | Unannotated protein; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.719 |
clpA | clpP | GCA_001458595_01484 | GCA_001458595_01871 | Unannotated protein; Belongs to the ClpA/ClpB family. | Unannotated protein; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.911 |
clpA | clpX | GCA_001458595_01484 | GCA_001458595_01872 | Unannotated protein; Belongs to the ClpA/ClpB family. | Unannotated protein; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.520 |
clpA | groL | GCA_001458595_01484 | GCA_001458595_00445 | Unannotated protein; Belongs to the ClpA/ClpB family. | Unannotated protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.769 |
clpA | groS | GCA_001458595_01484 | GCA_001458595_00446 | Unannotated protein; Belongs to the ClpA/ClpB family. | Unannotated protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.772 |
clpA | grpE | GCA_001458595_01484 | GCA_001458595_03643 | Unannotated protein; Belongs to the ClpA/ClpB family. | Unannotated protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depe [...] | 0.851 |
clpA | hrcA | GCA_001458595_01484 | GCA_001458595_03644 | Unannotated protein; Belongs to the ClpA/ClpB family. | Unannotated protein; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.738 |
clpA | lon | GCA_001458595_01484 | GCA_001458595_01874 | Unannotated protein; Belongs to the ClpA/ClpB family. | Unannotated protein; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.719 |
clpB | clpP | GCA_001458595_01210 | GCA_001458595_01871 | Unannotated protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Unannotated protein; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.955 |
clpB | clpX | GCA_001458595_01210 | GCA_001458595_01872 | Unannotated protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Unannotated protein; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.582 |
clpB | groL | GCA_001458595_01210 | GCA_001458595_00445 | Unannotated protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Unannotated protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.889 |
clpB | groS | GCA_001458595_01210 | GCA_001458595_00446 | Unannotated protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Unannotated protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.881 |
clpB | grpE | GCA_001458595_01210 | GCA_001458595_03643 | Unannotated protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Unannotated protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depe [...] | 0.929 |
clpB | hrcA | GCA_001458595_01210 | GCA_001458595_03644 | Unannotated protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Unannotated protein; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.742 |