STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sigFUnannotated protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (251 aa)    
Predicted Functional Partners:
spoIIAB
Unannotated protein; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
 
 
 0.995
spoIIAA
Unannotated protein; Belongs to the anti-sigma-factor antagonist family.
 
  
 0.982
CQ394_05455
Unannotated protein.
  
 
 0.887
spo0A
Unannotated protein; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
  
   
 0.800
spoIIE
Unannotated protein.
  
   
 0.775
spoVAC-2
Unannotated protein.
 
     0.764
CQ394_10325
Unannotated protein; Belongs to the sigma-70 factor family.
  
   
 0.763
spoVAE
Unannotated protein.
 
     0.753
spoVAE-2
Unannotated protein.
 
     0.752
spoIVB
Unannotated protein.
  
   
 0.748
Your Current Organism:
Clostridium neonatale
NCBI taxonomy Id: 137838
Other names: ATCC BAA-265, C. neonatale, CCUG 46077, strain AIP 250.09, strain LCDC 99A005, strain NML 99-A-005, strain NML 99A005, strain St. Boniface Hospital 30686
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.