| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KXB58492.1 | KXB63173.1 | HMPREF3186_01366 | HMPREF3186_00204 | Putative D-lactate dehydrogenase; KEGG: mcl:MCCL_0071 2.7e-80 D-specific D-2-hydroxyacid dehydrogenase; K03778 D-lactate dehydrogenase; Psort location: Cytoplasmic, score: 9.97. | HAD hydrolase, family IB; KEGG: cbj:H04402_01157 4.2e-66 phosphoserine phosphatase; Psort location: CytoplasmicMembrane, score: 8.16. | 0.456 |
| KXB58492.1 | MetH | HMPREF3186_01366 | HMPREF3186_00627 | Putative D-lactate dehydrogenase; KEGG: mcl:MCCL_0071 2.7e-80 D-specific D-2-hydroxyacid dehydrogenase; K03778 D-lactate dehydrogenase; Psort location: Cytoplasmic, score: 9.97. | KEGG: smn:SMA_1241 8.6e-226 5,10-methylenetetrahydrofolate reductase/Homolog of homocysteine-binding domain; K00547 homocysteine S-methyltransferase; Psort location: Cytoplasmic, score: 7.50. | 0.750 |
| KXB58492.1 | ThrC | HMPREF3186_01366 | HMPREF3186_00225 | Putative D-lactate dehydrogenase; KEGG: mcl:MCCL_0071 2.7e-80 D-specific D-2-hydroxyacid dehydrogenase; K03778 D-lactate dehydrogenase; Psort location: Cytoplasmic, score: 9.97. | Threonine synthase; KEGG: sri:SELR_19610 3.1e-134 thrC; putative threonine synthase K01733; Psort location: Cytoplasmic, score: 7.50. | 0.553 |
| KXB58492.1 | glyA | HMPREF3186_01366 | HMPREF3186_00536 | Putative D-lactate dehydrogenase; KEGG: mcl:MCCL_0071 2.7e-80 D-specific D-2-hydroxyacid dehydrogenase; K03778 D-lactate dehydrogenase; Psort location: Cytoplasmic, score: 9.97. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.497 |
| KXB63173.1 | KXB58492.1 | HMPREF3186_00204 | HMPREF3186_01366 | HAD hydrolase, family IB; KEGG: cbj:H04402_01157 4.2e-66 phosphoserine phosphatase; Psort location: CytoplasmicMembrane, score: 8.16. | Putative D-lactate dehydrogenase; KEGG: mcl:MCCL_0071 2.7e-80 D-specific D-2-hydroxyacid dehydrogenase; K03778 D-lactate dehydrogenase; Psort location: Cytoplasmic, score: 9.97. | 0.456 |
| KXB63173.1 | KXB63174.1 | HMPREF3186_00204 | HMPREF3186_00205 | HAD hydrolase, family IB; KEGG: cbj:H04402_01157 4.2e-66 phosphoserine phosphatase; Psort location: CytoplasmicMembrane, score: 8.16. | Oligoendopeptidase, M3 family; KEGG: lba:Lebu_0122 1.8e-184 oligoendopeptidase; K01417. | 0.636 |
| KXB63173.1 | MetH | HMPREF3186_00204 | HMPREF3186_00627 | HAD hydrolase, family IB; KEGG: cbj:H04402_01157 4.2e-66 phosphoserine phosphatase; Psort location: CytoplasmicMembrane, score: 8.16. | KEGG: smn:SMA_1241 8.6e-226 5,10-methylenetetrahydrofolate reductase/Homolog of homocysteine-binding domain; K00547 homocysteine S-methyltransferase; Psort location: Cytoplasmic, score: 7.50. | 0.544 |
| KXB63173.1 | ThrC | HMPREF3186_00204 | HMPREF3186_00225 | HAD hydrolase, family IB; KEGG: cbj:H04402_01157 4.2e-66 phosphoserine phosphatase; Psort location: CytoplasmicMembrane, score: 8.16. | Threonine synthase; KEGG: sri:SELR_19610 3.1e-134 thrC; putative threonine synthase K01733; Psort location: Cytoplasmic, score: 7.50. | 0.411 |
| KXB63173.1 | glyA | HMPREF3186_00204 | HMPREF3186_00536 | HAD hydrolase, family IB; KEGG: cbj:H04402_01157 4.2e-66 phosphoserine phosphatase; Psort location: CytoplasmicMembrane, score: 8.16. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.455 |
| KXB63173.1 | rnmV | HMPREF3186_00204 | HMPREF3186_00237 | HAD hydrolase, family IB; KEGG: cbj:H04402_01157 4.2e-66 phosphoserine phosphatase; Psort location: CytoplasmicMembrane, score: 8.16. | Ribonuclease M5; Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step. | 0.509 |
| KXB63174.1 | KXB63173.1 | HMPREF3186_00205 | HMPREF3186_00204 | Oligoendopeptidase, M3 family; KEGG: lba:Lebu_0122 1.8e-184 oligoendopeptidase; K01417. | HAD hydrolase, family IB; KEGG: cbj:H04402_01157 4.2e-66 phosphoserine phosphatase; Psort location: CytoplasmicMembrane, score: 8.16. | 0.636 |
| MetH | KXB58492.1 | HMPREF3186_00627 | HMPREF3186_01366 | KEGG: smn:SMA_1241 8.6e-226 5,10-methylenetetrahydrofolate reductase/Homolog of homocysteine-binding domain; K00547 homocysteine S-methyltransferase; Psort location: Cytoplasmic, score: 7.50. | Putative D-lactate dehydrogenase; KEGG: mcl:MCCL_0071 2.7e-80 D-specific D-2-hydroxyacid dehydrogenase; K03778 D-lactate dehydrogenase; Psort location: Cytoplasmic, score: 9.97. | 0.750 |
| MetH | KXB63173.1 | HMPREF3186_00627 | HMPREF3186_00204 | KEGG: smn:SMA_1241 8.6e-226 5,10-methylenetetrahydrofolate reductase/Homolog of homocysteine-binding domain; K00547 homocysteine S-methyltransferase; Psort location: Cytoplasmic, score: 7.50. | HAD hydrolase, family IB; KEGG: cbj:H04402_01157 4.2e-66 phosphoserine phosphatase; Psort location: CytoplasmicMembrane, score: 8.16. | 0.544 |
| MetH | ThrC | HMPREF3186_00627 | HMPREF3186_00225 | KEGG: smn:SMA_1241 8.6e-226 5,10-methylenetetrahydrofolate reductase/Homolog of homocysteine-binding domain; K00547 homocysteine S-methyltransferase; Psort location: Cytoplasmic, score: 7.50. | Threonine synthase; KEGG: sri:SELR_19610 3.1e-134 thrC; putative threonine synthase K01733; Psort location: Cytoplasmic, score: 7.50. | 0.599 |
| MetH | glyA | HMPREF3186_00627 | HMPREF3186_00536 | KEGG: smn:SMA_1241 8.6e-226 5,10-methylenetetrahydrofolate reductase/Homolog of homocysteine-binding domain; K00547 homocysteine S-methyltransferase; Psort location: Cytoplasmic, score: 7.50. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.962 |
| ThrC | KXB58492.1 | HMPREF3186_00225 | HMPREF3186_01366 | Threonine synthase; KEGG: sri:SELR_19610 3.1e-134 thrC; putative threonine synthase K01733; Psort location: Cytoplasmic, score: 7.50. | Putative D-lactate dehydrogenase; KEGG: mcl:MCCL_0071 2.7e-80 D-specific D-2-hydroxyacid dehydrogenase; K03778 D-lactate dehydrogenase; Psort location: Cytoplasmic, score: 9.97. | 0.553 |
| ThrC | KXB63173.1 | HMPREF3186_00225 | HMPREF3186_00204 | Threonine synthase; KEGG: sri:SELR_19610 3.1e-134 thrC; putative threonine synthase K01733; Psort location: Cytoplasmic, score: 7.50. | HAD hydrolase, family IB; KEGG: cbj:H04402_01157 4.2e-66 phosphoserine phosphatase; Psort location: CytoplasmicMembrane, score: 8.16. | 0.411 |
| ThrC | MetH | HMPREF3186_00225 | HMPREF3186_00627 | Threonine synthase; KEGG: sri:SELR_19610 3.1e-134 thrC; putative threonine synthase K01733; Psort location: Cytoplasmic, score: 7.50. | KEGG: smn:SMA_1241 8.6e-226 5,10-methylenetetrahydrofolate reductase/Homolog of homocysteine-binding domain; K00547 homocysteine S-methyltransferase; Psort location: Cytoplasmic, score: 7.50. | 0.599 |
| glyA | KXB58492.1 | HMPREF3186_00536 | HMPREF3186_01366 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative D-lactate dehydrogenase; KEGG: mcl:MCCL_0071 2.7e-80 D-specific D-2-hydroxyacid dehydrogenase; K03778 D-lactate dehydrogenase; Psort location: Cytoplasmic, score: 9.97. | 0.497 |
| glyA | KXB63173.1 | HMPREF3186_00536 | HMPREF3186_00204 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | HAD hydrolase, family IB; KEGG: cbj:H04402_01157 4.2e-66 phosphoserine phosphatase; Psort location: CytoplasmicMembrane, score: 8.16. | 0.455 |