| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KXB63106.1 | RibE | HMPREF3186_00292 | HMPREF3186_00293 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | KEGG: stb:SGPB_0568 6.4e-63 ribE; riboflavin synthase subunit alpha K00793; Psort location: Cytoplasmic, score: 9.67. | 0.999 |
| KXB63106.1 | RibF | HMPREF3186_00292 | HMPREF3186_00563 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | KEGG: cpr:CPR_1654 1.6e-57 ribF; bifunctional riboflavin kinase/FMN adenylyltransferase K11753; Psort location: Cytoplasmic, score: 7.50; Belongs to the ribF family. | 0.731 |
| KXB63106.1 | ribA | HMPREF3186_00292 | HMPREF3186_00294 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | 0.999 |
| KXB63106.1 | ribH | HMPREF3186_00292 | HMPREF3186_00295 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.999 |
| Npr_1 | RibE | HMPREF3186_00403 | HMPREF3186_00293 | NADH peroxidase family protein; KEGG: ser:SERP2165 2.1e-89 pyridine nucleotide-disulfide oxidoreductase; K00359 NADH oxidase; Psort location: Cytoplasmic, score: 9.97. | KEGG: stb:SGPB_0568 6.4e-63 ribE; riboflavin synthase subunit alpha K00793; Psort location: Cytoplasmic, score: 9.67. | 0.539 |
| Npr_1 | rpmE2 | HMPREF3186_00403 | HMPREF3186_01662 | NADH peroxidase family protein; KEGG: ser:SERP2165 2.1e-89 pyridine nucleotide-disulfide oxidoreductase; K00359 NADH oxidase; Psort location: Cytoplasmic, score: 9.97. | Ribosomal protein L31; KEGG: apb:SAR116_2278 5.1e-06 50S ribosomal protein L31 K02909; Psort location: Cytoplasmic, score: 9.67. | 0.538 |
| RibE | KXB63106.1 | HMPREF3186_00293 | HMPREF3186_00292 | KEGG: stb:SGPB_0568 6.4e-63 ribE; riboflavin synthase subunit alpha K00793; Psort location: Cytoplasmic, score: 9.67. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.999 |
| RibE | Npr_1 | HMPREF3186_00293 | HMPREF3186_00403 | KEGG: stb:SGPB_0568 6.4e-63 ribE; riboflavin synthase subunit alpha K00793; Psort location: Cytoplasmic, score: 9.67. | NADH peroxidase family protein; KEGG: ser:SERP2165 2.1e-89 pyridine nucleotide-disulfide oxidoreductase; K00359 NADH oxidase; Psort location: Cytoplasmic, score: 9.97. | 0.539 |
| RibE | RibF | HMPREF3186_00293 | HMPREF3186_00563 | KEGG: stb:SGPB_0568 6.4e-63 ribE; riboflavin synthase subunit alpha K00793; Psort location: Cytoplasmic, score: 9.67. | KEGG: cpr:CPR_1654 1.6e-57 ribF; bifunctional riboflavin kinase/FMN adenylyltransferase K11753; Psort location: Cytoplasmic, score: 7.50; Belongs to the ribF family. | 0.935 |
| RibE | pheS | HMPREF3186_00293 | HMPREF3186_01737 | KEGG: stb:SGPB_0568 6.4e-63 ribE; riboflavin synthase subunit alpha K00793; Psort location: Cytoplasmic, score: 9.67. | KEGG: afl:Aflv_0542 7.6e-115 pheS; phenylalanyl-tRNA synthetase subunit alpha; K01889 phenylalanyl-tRNA synthetase alpha chain; Psort location: Cytoplasmic, score: 10.00. | 0.453 |
| RibE | ribA | HMPREF3186_00293 | HMPREF3186_00294 | KEGG: stb:SGPB_0568 6.4e-63 ribE; riboflavin synthase subunit alpha K00793; Psort location: Cytoplasmic, score: 9.67. | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | 0.999 |
| RibE | ribH | HMPREF3186_00293 | HMPREF3186_00295 | KEGG: stb:SGPB_0568 6.4e-63 ribE; riboflavin synthase subunit alpha K00793; Psort location: Cytoplasmic, score: 9.67. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.999 |
| RibE | rpmE2 | HMPREF3186_00293 | HMPREF3186_01662 | KEGG: stb:SGPB_0568 6.4e-63 ribE; riboflavin synthase subunit alpha K00793; Psort location: Cytoplasmic, score: 9.67. | Ribosomal protein L31; KEGG: apb:SAR116_2278 5.1e-06 50S ribosomal protein L31 K02909; Psort location: Cytoplasmic, score: 9.67. | 0.538 |
| RibF | KXB63106.1 | HMPREF3186_00563 | HMPREF3186_00292 | KEGG: cpr:CPR_1654 1.6e-57 ribF; bifunctional riboflavin kinase/FMN adenylyltransferase K11753; Psort location: Cytoplasmic, score: 7.50; Belongs to the ribF family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.731 |
| RibF | RibE | HMPREF3186_00563 | HMPREF3186_00293 | KEGG: cpr:CPR_1654 1.6e-57 ribF; bifunctional riboflavin kinase/FMN adenylyltransferase K11753; Psort location: Cytoplasmic, score: 7.50; Belongs to the ribF family. | KEGG: stb:SGPB_0568 6.4e-63 ribE; riboflavin synthase subunit alpha K00793; Psort location: Cytoplasmic, score: 9.67. | 0.935 |
| RibF | ribA | HMPREF3186_00563 | HMPREF3186_00294 | KEGG: cpr:CPR_1654 1.6e-57 ribF; bifunctional riboflavin kinase/FMN adenylyltransferase K11753; Psort location: Cytoplasmic, score: 7.50; Belongs to the ribF family. | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | 0.640 |
| RibF | ribH | HMPREF3186_00563 | HMPREF3186_00295 | KEGG: cpr:CPR_1654 1.6e-57 ribF; bifunctional riboflavin kinase/FMN adenylyltransferase K11753; Psort location: Cytoplasmic, score: 7.50; Belongs to the ribF family. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.741 |
| pheS | RibE | HMPREF3186_01737 | HMPREF3186_00293 | KEGG: afl:Aflv_0542 7.6e-115 pheS; phenylalanyl-tRNA synthetase subunit alpha; K01889 phenylalanyl-tRNA synthetase alpha chain; Psort location: Cytoplasmic, score: 10.00. | KEGG: stb:SGPB_0568 6.4e-63 ribE; riboflavin synthase subunit alpha K00793; Psort location: Cytoplasmic, score: 9.67. | 0.453 |
| ribA | KXB63106.1 | HMPREF3186_00294 | HMPREF3186_00292 | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.999 |
| ribA | RibE | HMPREF3186_00294 | HMPREF3186_00293 | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | KEGG: stb:SGPB_0568 6.4e-63 ribE; riboflavin synthase subunit alpha K00793; Psort location: Cytoplasmic, score: 9.67. | 0.999 |