STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tmkdTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (208 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.941
NrdE
Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
  
 
 0.940
tdk
Thymidine kinase; KEGG: sau:SA1921 2.2e-62 tdk; thymidine kinase K00857; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.938
NrdF
KEGG: ssp:SSP1985 7.4e-117 nrdF; ribonucleotide-diphosphate reductase subunit beta K00526; Psort location: Cytoplasmic, score: 7.50.
  
 
 0.931
KXB63641.1
KEGG: sha:SH1326 5.5e-57 comEB; late competence operon required for DNA binding and uptake; K01493 dCMP deaminase; Psort location: Cytoplasmic, score: 7.50.
    
 0.927
KXB62129.1
KEGG: bcl:ABC0052 2.2e-29 holB; DNA polymerase III subunit delta' K02341; Psort location: Cytoplasmic, score: 7.50.
 
  
 0.917
KXB62130.1
Hypothetical protein; KEGG: sud:ST398NM01_0553 6.6e-45 Methyltransferase; Psort location: Cytoplasmic, score: 7.50.
 
    0.917
recR
Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
    
 0.884
rsmI
S-adenosylmethionine-dependent methyltransferase, YraL family; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
 
    0.883
KXB62131.1
GIY-YIG catalytic domain protein; KEGG: cnc:CNE_2c01410 6.0e-12 cho1; excinuclease Cho K07461.
       0.794
Your Current Organism:
Gemella haemolysans
NCBI taxonomy Id: 1379
Other names: ATCC 10379, CCUG 37985, CIP 101126, G. haemolysans, LMG 18984, LMG:18984, NCTC 12968, Neisseria haemolysans
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