STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RelA_2GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (757 aa)    
Predicted Functional Partners:
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
  
 
 0.918
YwaC
RelA/SpoT domain protein; KEGG: bbp:BBPR_1279 2.8e-46 relA2; GTP pyrophosphokinase; Psort location: Cytoplasmic, score: 7.50.
    
 0.911
Pyk_1
Pyruvate kinase, barrel domain protein; KEGG: clc:Calla_0654 2.8e-64 pyruvate kinase; K00873 pyruvate kinase; Psort location: Cytoplasmic, score: 7.50.
  
 
 0.903
Pyk_2
Pyruvate kinase; KEGG: afl:Aflv_0500 2.0e-153 pyruvate kinase; K00873 pyruvate kinase; Psort location: Cytoplasmic, score: 7.50.
  
 
 0.903
Pyk_3
Pyruvate kinase, barrel domain protein; KEGG: chd:Calhy_1460 9.2e-68 pyruvate kinase; K00873 pyruvate kinase; Psort location: Cytoplasmic, score: 7.50.
  
 
 0.903
NrdE
Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
     
 0.900
NrdF
KEGG: ssp:SSP1985 7.4e-117 nrdF; ribonucleotide-diphosphate reductase subunit beta K00526; Psort location: Cytoplasmic, score: 7.50.
     
  0.900
NrdD
KEGG: efi:OG1RF_12115 1.4e-294 nrdD; anaerobic ribonucleoside-triphosphate reductase large subunit K00527; Psort location: Cytoplasmic, score: 7.50.
    
 0.900
dtd
D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family.
  
    0.853
ribA
3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family.
  
 
 0.848
Your Current Organism:
Gemella haemolysans
NCBI taxonomy Id: 1379
Other names: ATCC 10379, CCUG 37985, CIP 101126, G. haemolysans, LMG 18984, LMG:18984, NCTC 12968, Neisseria haemolysans
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