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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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filled nodes:
a 3D structure is known or predicted
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glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (405 aa)    
Predicted Functional Partners:
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: hhd:HBHAL_1598 5.6e-151 purH; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase.
  
 0.985
folD
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
 
 0.984
fhs
KEGG: tsh:Tsac_0941 6.5e-173 Formate--tetrahydrofolate ligase; K01938 formate--tetrahydrofolate ligase; Psort location: Cytoplasmic, score: 7.50.
  
 0.972
MetH
KEGG: smn:SMA_1241 8.6e-226 5,10-methylenetetrahydrofolate reductase/Homolog of homocysteine-binding domain; K00547 homocysteine S-methyltransferase; Psort location: Cytoplasmic, score: 7.50.
  
 
 0.969
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
  
 0.964
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.962
SdhA
KEGG: ssd:SPSINT_0935 2.8e-92 L-serine dehydratase subunit alpha K01752; Belongs to the iron-sulfur dependent L-serine dehydratase family.
  
 
 0.960
SdhB
KEGG: ssd:SPSINT_0934 7.4e-46 L-serine dehydratase subunit beta K01752; Psort location: Cytoplasmic, score: 7.50; Belongs to the iron-sulfur dependent L-serine dehydratase family.
  
 
 0.958
PurL
KEGG: ipo:Ilyop_2204 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97.
  
  
 0.957
KXB62705.1
Dihydrolipoyl dehydrogenase; KEGG: sgo:SGO_1130 6.0e-186 dihydrolipoamide dehydrogenase K00382; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.949
Your Current Organism:
Gemella haemolysans
NCBI taxonomy Id: 1379
Other names: ATCC 10379, CCUG 37985, CIP 101126, G. haemolysans, LMG 18984, LMG:18984, NCTC 12968, Neisseria haemolysans
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